口服小剂量糖皮质激素联合茶碱治疗农村贫困地区老年哮喘的疗效观察
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摘要
目的:探究小剂量糖皮质激素和茶碱联合应用于农村贫困地区老年哮喘患者临床治疗效果。方法:随机选取本院2013年7月至2015年7月间收治入院的老年哮喘患者90例,并按照随机双盲法原则将其分成观察组和对照组,各45例,对照组采用单纯的糖皮质激素治疗,观察组采用小剂量强的松联合茶碱治疗,比较两组患者的疗效以及用药后1秒用力呼气容积(FEV1)变化情况,并分析药物依从性、医疗费用以及不良反应情况。结果:观察组临床疗效以及肺功能的改善情况较对照组,差异无显著性(P>0.05),同时观察两组患者不良反应发现,差异无统计学意义(P>0.05),但观察组患者依从性较对照组高,且医疗费用较对照组少,差异具有显著性(P<0.05)。结论:小剂量糖皮质激素(强的松)联合茶碱药用于贫困地区老年哮喘患者的治疗,对于提高患者临床疗效具有重要的意义,且不良反应较少,患者依从性较高,产生的医疗费用较少,值得推广。
Objective: To explore the combined application of low dose glucocorticoid hormone and theophylline in clinical treatment of elderly patients with asthma in poor rural areas. Methods: 90 elderly patients with asthma were randomly selected in our hospital from July 2013 to July 2015 admitted to hospital patients, and in accordance with the principle of random double blindApproach divided into observation group and control group, 45 cases in each, the control group using glucocorticoid treatment alone, the observation group was treated with small dose of prednisonecombined with theophylline treatment, compare the curative effect of two groups of patients after treatment and forced expiratory volume(FEV1) changes, and analysis of drug compliance, medical costsand adverse reactions. Results: the improvement of clinical curative effect of observation group and lung the function compared with the control group, no significant difference(P > 0.05), and observethe adverse reactions of the two groups found no statistically significant difference(P > 0.05), but the patients in the observation group than for compliance According to the group, and medical expensesis less than that of the control group, the difference is significant(P < 0.05). Conclusion: small dose of glucocorticoid hormones(prednisone) combined with theophylline drugs for treatment of asthmain the elderly patients in poor areas, the plays a important role in improving the clinical efficacy and less adverse reactions, patients with higher compliance, medical expenses incurred less, worthy of promotion
引文
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