Structural and functional characterization of neutralizing antibodies against MERS-CoV and influenza virus
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- 英文论文题名：Structural and functional characterization of neutralizing antibodies against MERS-CoV and influenza virus
- 论文作者：Xinquan Wang
- 英文论文作者：Xinquan Wang ; Beijing Advanced Innovation Center for Structural Biology ; MOE Key Laboratory of Protein Science ; School of Life Sciences ; Tsinghua University
- 年：2016
- 作者机构：Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Protein Science, School of Life Sciences, Tsinghua University;
- 会议召开时间：2016-04-27
- 会议录名称：第五届中国结构生物学学术讨论会摘要集
- 语种：英文
- 分类号：R392
- 学会代码：ZGWI
- 会议名称：第五届中国结构生物学学术讨论会
- 会议地点：中国广东深圳
- 主办单位：中国生物物理学会分子生物物理学专业委员会
- 学会名称：中国生物物理学会
- 页数：1
- 文件大小：75k
- 原文格式：D
- 会议级别：全国
摘要
Neutralizing antibodies are essential in antiviral immunity and are instrumental in preventing and treating viral diseases. They neutralize the cell entry of enveloped viruses by targeting viral glycoproteins, which bind to cellular receptors and mediate the fusion of viral and cellular membranes. High resolution structures of neutralizing antibodies with viral glycoproteins provide atomic description of the paratope-epitope interface, which is important for understanding the molecular mechanisms of antibody recognition and designing better antigen for vaccine development. Here we present our recent work on structural and functional characterization of neutralizing antibodies targeting MERS-Co V spike glycoprotein and antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 virus infection.
Neutralizing antibodies are essential in antiviral immunity and are instrumental in preventing and treating viral diseases. They neutralize the cell entry of enveloped viruses by targeting viral glycoproteins, which bind to cellular receptors and mediate the fusion of viral and cellular membranes. High resolution structures of neutralizing antibodies with viral glycoproteins provide atomic description of the paratope-epitope interface, which is important for understanding the molecular mechanisms of antibody recognition and designing better antigen for vaccine development. Here we present our recent work on structural and functional characterization of neutralizing antibodies targeting MERS-Co V spike glycoprotein and antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 virus infection.
Neutralizing antibodies are essential in antiviral immunity and are instrumental in preventing and treating viral diseases. They neutralize the cell entry of enveloped viruses by targeting viral glycoproteins, which bind to cellular receptors and mediate the fusion of viral and cellular membranes. High resolution structures of neutralizing antibodies with viral glycoproteins provide atomic description of the paratope-epitope interface, which is important for understanding the molecular mechanisms of antibody recognition and designing better antigen for vaccine development. Here we present our recent work on structural and functional characterization of neutralizing antibodies targeting MERS-Co V spike glycoprotein and antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 virus infection.
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