基于反应规则的生物合成途径设计
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- 英文论文题名：Design of Biosynthetic Pathway Based on Reaction Patterns
- 论文作者：吴玲 ; 邓喆 ; 涂伟忠 ; 丁邵珍 ; 胡黔楠
- 英文论文作者：LWu ; Z Deng ; W-Z Tu ; S-Z Ding ; Q-N Hu ; Tianjin Institute of Industrial Biotechnology ; Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院天津工业生物技术研究所;
- 论文关键词：反应规则 ; 化学结构转化 ; 生物合成 ; 途径设计
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十五分会：化学信息学与化学计量学
- 语种：中文
- 分类号：Q81
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十五分会 ; 化学信息学与化学计量学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：278k
- 原文格式：D
- 会议级别：全国
摘要
在合成生物学的理性设计中,生物合成途径的设计是非常关键性的一个环节。一条完整的生物合成途径往往涉及了多个复杂的生物合成反应,每一个生物合成反应又对应了一种化学结构之间的转化方式,涉及到不同元件和功能模块。化合物的生物合成几乎都是从简单的小分子前体开始,经由一系列顺序协作的酶催化反应而最终形成。组装一条全新的生物合成途径需要结合目标化合物的结构特征,根据已有的一些反应规则来推测其可能的合成前体化合物,确定相应的生化反应类型,寻找相关的元件和功能模块来实现。我们拟汇报在基于反应规则来设计生物合成途径过程中,反应规则的挖掘,反应类型的分类以及反应催化酶的预测方面取得的一些研究进展。相关工作细节可参见课题组网站:http://www.lifemodules.org/.
The design or biosynthetic pathway is a key link in the rational design or synthetic biology.A complete biosynthetic pathway often contain multiple complex reactions,and each reaction correspondind to different functional components and modules involves one or more transformation between chemical structures.Allmost all of natural product's biosynthesis start from small molecular,eventually formed via a series of enzyme-catalyzed reactions.Assembling a new biosynthetic pathway usually need to take the target compound into account,according to existing reaction patterns,infer some possible precursors,and also confirm the reaction type to look for relevant functional components and modules.This proposed report,we intend to make a presentation about some new progress we have made in the reaction patterns' mining,patterns' categorization,and assignment of EC Numbers to enzymatic reactions.Details of the work are freely available via:http://www.lifemodules.org/.
The design or biosynthetic pathway is a key link in the rational design or synthetic biology.A complete biosynthetic pathway often contain multiple complex reactions,and each reaction correspondind to different functional components and modules involves one or more transformation between chemical structures.Allmost all of natural product's biosynthesis start from small molecular,eventually formed via a series of enzyme-catalyzed reactions.Assembling a new biosynthetic pathway usually need to take the target compound into account,according to existing reaction patterns,infer some possible precursors,and also confirm the reaction type to look for relevant functional components and modules.This proposed report,we intend to make a presentation about some new progress we have made in the reaction patterns' mining,patterns' categorization,and assignment of EC Numbers to enzymatic reactions.Details of the work are freely available via:http://www.lifemodules.org/.
引文
[1]Qian-Nan Hu1,*,Zhe Deng1,Huanan Hu2,3,Dong-Sheng Cao4 and Yi-Zeng Liang4.Bioinformatics.2011,27(17):2465-7.
[2]Hu QN1,Zhu H,Li X,Zhang M,Deng Z,Yang X,Deng Z.PLoS One.2012,7(12):e52901.
[3]Q-N Hu1,Z Deng1,W Tu1,XYang1,Z-B Meng2,Z-X Deng1 and J Liu2.CPT Pharmacometrics Syst.Pharmacol.2014,3:e105.
[4]Weizhong Tu1,Haoran Zhang2,Juan Liu2 and Qian-Nan Hu1,3,*.Bioinformatics.2016,32(3):472-3.
[2]Hu QN1,Zhu H,Li X,Zhang M,Deng Z,Yang X,Deng Z.PLoS One.2012,7(12):e52901.
[3]Q-N Hu1,Z Deng1,W Tu1,XYang1,Z-B Meng2,Z-X Deng1 and J Liu2.CPT Pharmacometrics Syst.Pharmacol.2014,3:e105.
[4]Weizhong Tu1,Haoran Zhang2,Juan Liu2 and Qian-Nan Hu1,3,*.Bioinformatics.2016,32(3):472-3.