摘要
Human leukocyte antigen G(HLA-G), a non-classic major histocompatibility complex(MHC) class I molecule, functions as a potent immune inhibitory molecule. The immune suppressive features of HLA-G include inhibition of immune cell cytotoxicity, differentiation, proliferation and alteration of the profile of cytokine secretion; induction of immune cell apoptosis; generation of regulatory cells and expansion of myeloid derived suppressive cells, and by impairment of chemotaxis. In the context of malignancies, aberrant induction of HLA-G expression has been observed in various tumor cells, in addition to above mentioned immune inhibitory function mediated by HLA-G, HLA-G could also arm tumor cells with higher migration, invasive and metastatic potential with the up-regulation of tumor-promoting factor expression such as the matrix metalloproteinases. In clinical settings, tumor HLA-G expression was found strongly associated with advanced disease stage and related to the poor prognosis for cancer patients. These findings indicated ectopic HLAG expression in tumors could render multiple effects during the progression of malignancies. In this review, we will briefly present an overview of what the mechanisms and significance of HLA-G involved in promoting tumor cell immune escaping, metastasis and disease progression, and what measures can be taken to counteract cancer development by targeting HLA-G.
Human leukocyte antigen G(HLA-G), a non-classic major histocompatibility complex(MHC) class I molecule, functions as a potent immune inhibitory molecule. The immune suppressive features of HLA-G include inhibition of immune cell cytotoxicity, differentiation, proliferation and alteration of the profile of cytokine secretion; induction of immune cell apoptosis; generation of regulatory cells and expansion of myeloid derived suppressive cells, and by impairment of chemotaxis. In the context of malignancies, aberrant induction of HLA-G expression has been observed in various tumor cells, in addition to above mentioned immune inhibitory function mediated by HLA-G, HLA-G could also arm tumor cells with higher migration, invasive and metastatic potential with the up-regulation of tumor-promoting factor expression such as the matrix metalloproteinases. In clinical settings, tumor HLA-G expression was found strongly associated with advanced disease stage and related to the poor prognosis for cancer patients. These findings indicated ectopic HLAG expression in tumors could render multiple effects during the progression of malignancies. In this review, we will briefly present an overview of what the mechanisms and significance of HLA-G involved in promoting tumor cell immune escaping, metastasis and disease progression, and what measures can be taken to counteract cancer development by targeting HLA-G.
引文