Elevation of plasma soluble HLA-G expression is associated with a poor survival in patients with colorectal cancer
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- 英文论文题名：Elevation of plasma soluble HLA-G expression is associated with a poor survival in patients with colorectal cancer
- 论文作者：Lin Aifen ; Ruan Yan-Yun ; Li Jing-Bo ; Zhang Xia ; Yan Wei-Hua
- 英文论文作者：Lin Aifen ; Ruan Yan-Yun ; Li Jing-Bo ; Zhang Xia ; Yan Wei-Hua ; Human Tissue Bank ; Taizhou Hospital of Zhejiang Province ; Wenzhou Medical University ; Medical Research Center ; Taizhou Hospital of Zhejiang Province ; Wenzhou Medical University
- 年：2016
- 作者机构：Human Tissue Bank,Taizhou Hospital of Zhejiang Province,Wenzhou Medical University;Medical Research Center,Taizhou Hospital of Zhejiang Province,Wenzhou Medical University;
- 英文论文关键词：sHLA-G ; colorectal cancer ; prognosis
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会壁报交流集
- 英文会议录名称：Proceedings of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R735.34
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：379k
- 原文格式：D
- 会议级别：全国
摘要
Human leukocyte antigen(HLA-G) is a crucial immunotolerant involved in malignant cells immune escape and disease progression.High frequencies of tumor cell membrane-bound HLA-G and increased peripheral soluble HLA-G(s HLAG) expression have been observed in various malignancies.In this study,the prognostic significance of plasma s HLA-G in 178 patients with colorectal cancer(CRC) was evaluated.Levels of s HLA-G were analyzed by specific enzyme-linked immunosorbent assay.Median of s HLA-G levels were significantly increased in patients compared with controls(36.8 U/ml vs 4.7 U/ml,p<0.001).Among CRC subgroups,Median of s HLA-G levels in died CRC patients were with significantly higher than that in the survived CRC patients(46.8 U/ml vs 27.44 U/ml,p=0.012).Moreover,patients with s HLAG above median levels(≥ 36.8 U/ml) had a significantly shorter survival time(p<0.001).Multivariate analysis revealed that,in addition to patient age and tumor status,s HLA-G could be an independent prognostic factor in CRC patients.However,no significant correlation was found between s HLA-G levels and clinical parameters of the CRC patients studied.Taken together,our study provided the findings that plasma s HLA-G level is a potent predictor for prognosis in colorectal cancer patients.
Human leukocyte antigen(HLA-G) is a crucial immunotolerant involved in malignant cells immune escape and disease progression.High frequencies of tumor cell membrane-bound HLA-G and increased peripheral soluble HLA-G(s HLAG) expression have been observed in various malignancies.In this study,the prognostic significance of plasma s HLA-G in 178 patients with colorectal cancer(CRC) was evaluated.Levels of s HLA-G were analyzed by specific enzyme-linked immunosorbent assay.Median of s HLA-G levels were significantly increased in patients compared with controls(36.8 U/ml vs 4.7 U/ml,p<0.001).Among CRC subgroups,Median of s HLA-G levels in died CRC patients were with significantly higher than that in the survived CRC patients(46.8 U/ml vs 27.44 U/ml,p=0.012).Moreover,patients with s HLAG above median levels(≥ 36.8 U/ml) had a significantly shorter survival time(p<0.001).Multivariate analysis revealed that,in addition to patient age and tumor status,s HLA-G could be an independent prognostic factor in CRC patients.However,no significant correlation was found between s HLA-G levels and clinical parameters of the CRC patients studied.Taken together,our study provided the findings that plasma s HLA-G level is a potent predictor for prognosis in colorectal cancer patients.
Human leukocyte antigen(HLA-G) is a crucial immunotolerant involved in malignant cells immune escape and disease progression.High frequencies of tumor cell membrane-bound HLA-G and increased peripheral soluble HLA-G(s HLAG) expression have been observed in various malignancies.In this study,the prognostic significance of plasma s HLA-G in 178 patients with colorectal cancer(CRC) was evaluated.Levels of s HLA-G were analyzed by specific enzyme-linked immunosorbent assay.Median of s HLA-G levels were significantly increased in patients compared with controls(36.8 U/ml vs 4.7 U/ml,p<0.001).Among CRC subgroups,Median of s HLA-G levels in died CRC patients were with significantly higher than that in the survived CRC patients(46.8 U/ml vs 27.44 U/ml,p=0.012).Moreover,patients with s HLAG above median levels(≥ 36.8 U/ml) had a significantly shorter survival time(p<0.001).Multivariate analysis revealed that,in addition to patient age and tumor status,s HLA-G could be an independent prognostic factor in CRC patients.However,no significant correlation was found between s HLA-G levels and clinical parameters of the CRC patients studied.Taken together,our study provided the findings that plasma s HLA-G level is a potent predictor for prognosis in colorectal cancer patients.
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