转铁蛋白修饰的介孔二氧化硅在靶向药物控释中的应用
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- 英文论文题名：Transferrin Gated Mesoporous Silica Nanoparticles for Redox-Responsive and Targeted Drug Deliver
- 论文作者：陈晓露 ; 刘洪来 ; 韩霞
- 英文论文作者：Xiaolu Chen ; Honglai Liu ; Xia Han ; Key Laboratory for Advanced Materials and Department of Chemistry ; East China University of Science and Technology
- 年：2016
- 作者机构：华东理工大学化学院先进材料重点实验室;
- 论文关键词：介孔二氧化硅 ; 蛋白质 ; 靶向 ; 控释
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TQ460.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：136k
- 原文格式：D
- 会议级别：全国
摘要
介孔二氧化硅由于具有高的比表面积、均一可控的孔径、良好的生物相容性等优点,是近几十年来药物控释领域的研究热点~([1])。通过二硫键的连接,合成了转铁蛋白修饰的介孔二氧化硅,作为靶向控释药物载体。转铁蛋白包覆于介孔二氧化硅表面,既可以防止药物从孔中的泄露,同时由于癌细胞上转铁蛋白受体的高度表达,也起到了定向运输的作用。此体系在谷胱甘肽的刺激下,表现出良好的可控药物释放行为。这种简单的、生物相容性良好的生物分子/介孔二氧化硅体系,为设计靶向控释药物载体提供了新的思路。
This work reports on a targeted and controlled drug delivery system based on protein decorated mesoporous silica nanoparticles(MSNs). Transferrin, a naturally existing protein, grafted on the surfaces of MSNs via disulfide bonds, acts as both a capping agent and targeting ligand simultaneously. This system demonstrates great controllable drug release behavior in response to glutathione. The strategy makes full use of Tf, as to play a double role in delivery process, without introducing any redundant functionalities or complicated fabrication, providing us new ideas in design of MSN-based nanocontainers and also presenting great potential in site-specific, controlled-release drug delivery system.
This work reports on a targeted and controlled drug delivery system based on protein decorated mesoporous silica nanoparticles(MSNs). Transferrin, a naturally existing protein, grafted on the surfaces of MSNs via disulfide bonds, acts as both a capping agent and targeting ligand simultaneously. This system demonstrates great controllable drug release behavior in response to glutathione. The strategy makes full use of Tf, as to play a double role in delivery process, without introducing any redundant functionalities or complicated fabrication, providing us new ideas in design of MSN-based nanocontainers and also presenting great potential in site-specific, controlled-release drug delivery system.
引文
[1]Yang,P.;Gai,S.;Lin,J.Chem.Soc.Rev.2012,41:3679.