基于LC-MS/MS检测水中32种药物类物质的研究
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- 英文论文题名：A method for detection of 32 drugs in water based on LC-MS/MS
- 论文作者：关颖婷 ; 何欣 ; 聂晓静
- 英文论文作者：Yingting Guan ; Xin He ; Xiaojing Nie ; Key Laboratory of Industrial Ecology and Environmental Engineering of Ministry of Education ; College of Environment ; Dalian University of Technology
- 年：2016
- 作者机构：工业生态与环境工程教育部重点实验室大连理工大学环境学院;
- 论文关键词：药物 ; 高效液相色谱-串联质谱 ; 固相萃取
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十六分会：环境化学
- 语种：中文
- 分类号：X832;O657.63
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十六分会 ; 环境化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：201k
- 原文格式：D
- 会议级别：全国
摘要
药物包括抗生素、类固醇、消炎药、降压药、止痛药等,施用在人或动物体身上的药物只有15%能被机体完全吸收,大约85%以原形态或代谢物的形式随粪便、尿液等排出体外,进入环境中。本研究以辽东湾近海海域的水体为研究介质,甄别该地区水中主要药物类污染物,并针对这些污染物建立了一种固相萃取-高效液相色谱-串联质谱(SPE-HPLC-MS/MS)同时检测水中32种药物类污染物的分析方法。水样采用HLB固相萃取柱进行富集净化,采用0.1%(v:v)甲酸-1g/L甲酸铵水溶液和乙腈作为流动相,进行梯度洗脱,在多反应监测模式下进行定量,该方法的加标回收率为58.60%~140.56%。用该方法对辽东湾周边的排污口和入海口的18个水样进行检测,其中20种药物有检出,检出频率最高的为卡马西平,检出频率为89%。在研究的9种磺胺类抗生素中检出频率和浓度最高的物质均为甲氧苄啶,检出率为67%,最高检出浓度为28.95μg/L。
Solid-phase extraction combined with high performance liquid chromatography-tandem mass spectrometry(SPE-HPLC-MS/MS) was developed to detect 32 drugs in water of Liaodong Bay.As a result,20 kinds of drugs were detected for 18 samples.Carbamazepine was the most frequently detected compound with the detection rate of 89%.Of the 9 sulfonamide compounds studied,trimethoprim showed the highest detection rate and the highest concentration of 67% and 28.95 μg/L,respectively.
Solid-phase extraction combined with high performance liquid chromatography-tandem mass spectrometry(SPE-HPLC-MS/MS) was developed to detect 32 drugs in water of Liaodong Bay.As a result,20 kinds of drugs were detected for 18 samples.Carbamazepine was the most frequently detected compound with the detection rate of 89%.Of the 9 sulfonamide compounds studied,trimethoprim showed the highest detection rate and the highest concentration of 67% and 28.95 μg/L,respectively.
引文
[1]Zhang,Q.;Ying,G.;Pan,C.;Liu,Y.Environ.Sci.Technol.2015,49,6772-6782
[2]Na,G.;Fang,X.;Cai,Y.;Ge,L.Marine Pollution Bulletin.2013,69,233–237
[2]Na,G.;Fang,X.;Cai,Y.;Ge,L.Marine Pollution Bulletin.2013,69,233–237