Interleukin-1β Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer's disease
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- 英文论文题名：Interleukin-1β Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer's disease
- 论文作者：You Yin ; Jian-Hua Zhuang ; Zhong-Xin Zhao
- 英文论文作者：You Yin ; Jian-Hua Zhuang ; Zhong-Xin Zhao ; Department of Neurology ; Changzheng Hospital ; Second Military Medical University
- 年：2016
- 作者机构：Department of Neurology, Changzheng Hospital, Second Military Medical University;
- 会议召开时间：2016-05-27
- 会议录名称：中国睡眠研究会第九届学术年会汇编
- 语种：英文
- 分类号：R749.16;R740
- 学会代码：OGSF
- 会议名称：中国睡眠研究会第九届学术年会
- 会议地点：中国上海
- 主办单位：中国睡眠研究会
- 学会名称：中国睡眠研究会
- 页数：1
- 文件大小：45k
- 原文格式：O
- 会议级别：全国
摘要
Sleep alleviates Alzheimer's disease(AD)-related neuropathological processes,whereas sleep disturbance in AD patients is associated with elevated peripheral inflammatory cytokine levels.In the present study,we assessed interleukin(IL)-1β and APOEε4 polymorphisms for association with susceptibility of sleep disturbances in AD patients.A total of 123 pretreated AD patients and 120age-,gender- and education level-matched healthy controls were recruited for two consecutive full-night polysomnography and measurement of Epworth Sleepiness Scale(ESS) scores for sleepwake disturbance.Their genomic DNA was analyzed for IL-1β and APOEε4 SNPs using ligase detection reaction(LDR) technology.Blood levels of IL-1β,IL-6,and tumor necrosis factor alpha(TNF-α) were measured using ELISA after lipopolysaccharide(LPS) stimulation.The odds ratio and95%confidence interval for genotype-specific risk were calculated using an unconditional logistic regression model and adjusted by age,gender,educational levels,body mass index(BMI),and activities of daily living(ADL).Compared to the non-APOEε4/ε4 genotype,APOEε4/ε4 significantly increased the risk of AD(APOEε4/ε4 vs.non-APOEε4/ε4,adjusted OR = 4.33,95%CI = 1.33-14.10,p = 0.015).Compared to the IL-1β CC genotype(-31),the TT genotype significantly increased the risk of AD(TT vs.CC,adjusted OR = 1.72,95%CI = 1.13-2.61,p = 0.010).AD patients carrying the APOEε4 allele and the IL-1β TT genotype showed less time in bed,longer sleep latency and REM latency,more awakenings,and a lower SWS percentage than those carrying CC/CT combined genotypes.In addition,blood IL-1β levels were significantly greater in AD patients carrying both the APOEε4 allele and the IL-1β- 31 TT genotype than in those carrying the APOEε4 allele and the-31 TC or CC genotype.In conclusion,this study provides the first evidence indicating that the IL-1β-31 TT genotype and homozygous APOEε4 combined are associated with increased risk of developing AD with sleep disturbance.
Sleep alleviates Alzheimer's disease(AD)-related neuropathological processes,whereas sleep disturbance in AD patients is associated with elevated peripheral inflammatory cytokine levels.In the present study,we assessed interleukin(IL)-1β and APOEε4 polymorphisms for association with susceptibility of sleep disturbances in AD patients.A total of 123 pretreated AD patients and 120age-,gender- and education level-matched healthy controls were recruited for two consecutive full-night polysomnography and measurement of Epworth Sleepiness Scale(ESS) scores for sleepwake disturbance.Their genomic DNA was analyzed for IL-1β and APOEε4 SNPs using ligase detection reaction(LDR) technology.Blood levels of IL-1β,IL-6,and tumor necrosis factor alpha(TNF-α) were measured using ELISA after lipopolysaccharide(LPS) stimulation.The odds ratio and95%confidence interval for genotype-specific risk were calculated using an unconditional logistic regression model and adjusted by age,gender,educational levels,body mass index(BMI),and activities of daily living(ADL).Compared to the non-APOEε4/ε4 genotype,APOEε4/ε4 significantly increased the risk of AD(APOEε4/ε4 vs.non-APOEε4/ε4,adjusted OR = 4.33,95%CI = 1.33-14.10,p = 0.015).Compared to the IL-1β CC genotype(-31),the TT genotype significantly increased the risk of AD(TT vs.CC,adjusted OR = 1.72,95%CI = 1.13-2.61,p = 0.010).AD patients carrying the APOEε4 allele and the IL-1β TT genotype showed less time in bed,longer sleep latency and REM latency,more awakenings,and a lower SWS percentage than those carrying CC/CT combined genotypes.In addition,blood IL-1β levels were significantly greater in AD patients carrying both the APOEε4 allele and the IL-1β- 31 TT genotype than in those carrying the APOEε4 allele and the-31 TC or CC genotype.In conclusion,this study provides the first evidence indicating that the IL-1β-31 TT genotype and homozygous APOEε4 combined are associated with increased risk of developing AD with sleep disturbance.
Sleep alleviates Alzheimer's disease(AD)-related neuropathological processes,whereas sleep disturbance in AD patients is associated with elevated peripheral inflammatory cytokine levels.In the present study,we assessed interleukin(IL)-1β and APOEε4 polymorphisms for association with susceptibility of sleep disturbances in AD patients.A total of 123 pretreated AD patients and 120age-,gender- and education level-matched healthy controls were recruited for two consecutive full-night polysomnography and measurement of Epworth Sleepiness Scale(ESS) scores for sleepwake disturbance.Their genomic DNA was analyzed for IL-1β and APOEε4 SNPs using ligase detection reaction(LDR) technology.Blood levels of IL-1β,IL-6,and tumor necrosis factor alpha(TNF-α) were measured using ELISA after lipopolysaccharide(LPS) stimulation.The odds ratio and95%confidence interval for genotype-specific risk were calculated using an unconditional logistic regression model and adjusted by age,gender,educational levels,body mass index(BMI),and activities of daily living(ADL).Compared to the non-APOEε4/ε4 genotype,APOEε4/ε4 significantly increased the risk of AD(APOEε4/ε4 vs.non-APOEε4/ε4,adjusted OR = 4.33,95%CI = 1.33-14.10,p = 0.015).Compared to the IL-1β CC genotype(-31),the TT genotype significantly increased the risk of AD(TT vs.CC,adjusted OR = 1.72,95%CI = 1.13-2.61,p = 0.010).AD patients carrying the APOEε4 allele and the IL-1β TT genotype showed less time in bed,longer sleep latency and REM latency,more awakenings,and a lower SWS percentage than those carrying CC/CT combined genotypes.In addition,blood IL-1β levels were significantly greater in AD patients carrying both the APOEε4 allele and the IL-1β- 31 TT genotype than in those carrying the APOEε4 allele and the-31 TC or CC genotype.In conclusion,this study provides the first evidence indicating that the IL-1β-31 TT genotype and homozygous APOEε4 combined are associated with increased risk of developing AD with sleep disturbance.
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