The efficacy and immune response of Insulin-like growth factor 1 receptor(IGF-1R) inhibitor PQ401 on the cystic echinococcosis mice
详细信息 查看官网全文
- 英文论文题名：The efficacy and immune response of Insulin-like growth factor 1 receptor(IGF-1R) inhibitor PQ401 on the cystic echinococcosis mice
- 论文作者：Lü Guodong ; Wen Hao ; Lin Renyong
- 英文论文作者：Lü Guodong ; Wen Hao ; Lin Renyong ; State Key Lab Cultivation Base for Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis ; Clinical Medical Research Institute ; First Affiliated Hospital of Xinjiang Medical University
- 年：2016
- 作者机构：State Key Lab Cultivation Base for Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis,Clinical Medical Research Institute,First Affiliated Hospital of Xinjiang Medical University;
- 英文论文关键词：IGF-1R inhibitors ; PQ401 ; anti echinococcosis ; mice ; pharmacodynamics
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会摘要汇编
- 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：S852.4
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：352k
- 原文格式：D
- 会议级别：全国
摘要
Background: During the process of the lava of E. granulosus parasite in the intermediate host, the complicated signaling pathway of E. granulosus helps the helminth to evade from the immune system of the host. The insulin receptor signaling pathway, which could regulate the development, growth, glucose metabolism and motility of various parasites, is a crucial pathway in the parasite and becomes anti-helminth drug targets.Method: In order to detect the efficacy and immune response of insulin-like growth factor 1 receptor(IGF- 1R) inhibitor PQ401 on the cystic echinococcosis mice, PQ401 was used to treat the cystic echinococcosis mice, and the efficacy and immune response of PQ401 on the cystic echinococcosis mice were detected.Results: The difference of vesicle wet weight in the PQ401 100 mg/kg dose group and model group was significantly(P<0.05); the inhibitory rate of capsules in the PQ401 100 mg/kg, 50 mg/kg dose group, ABZ group were 53.20%, 40.45%, 57.08%, respectively; The weight of thymus were not different significantly between all groups(P>0.05), while the weight of spleen in PQ401 100 mg/kg dose group and ABZ group was significantly(P<0.05); The content of IL-2, INF-γ and TNF-α in the serum of PQ401 100 mg/kg dose group were elevated than model group and control group, while the content of IL-4 and IL-10 in the serum of PQ401 100 mg/kg dose group were reduced.Conclusion: PQ401 could inhibit the activity of the larva and influence the immune response of cystic echinococcosis mice.
Background: During the process of the lava of E. granulosus parasite in the intermediate host, the complicated signaling pathway of E. granulosus helps the helminth to evade from the immune system of the host. The insulin receptor signaling pathway, which could regulate the development, growth, glucose metabolism and motility of various parasites, is a crucial pathway in the parasite and becomes anti-helminth drug targets.Method: In order to detect the efficacy and immune response of insulin-like growth factor 1 receptor(IGF- 1R) inhibitor PQ401 on the cystic echinococcosis mice, PQ401 was used to treat the cystic echinococcosis mice, and the efficacy and immune response of PQ401 on the cystic echinococcosis mice were detected.Results: The difference of vesicle wet weight in the PQ401 100 mg/kg dose group and model group was significantly(P<0.05); the inhibitory rate of capsules in the PQ401 100 mg/kg, 50 mg/kg dose group, ABZ group were 53.20%, 40.45%, 57.08%, respectively; The weight of thymus were not different significantly between all groups(P>0.05), while the weight of spleen in PQ401 100 mg/kg dose group and ABZ group was significantly(P<0.05); The content of IL-2, INF-γ and TNF-α in the serum of PQ401 100 mg/kg dose group were elevated than model group and control group, while the content of IL-4 and IL-10 in the serum of PQ401 100 mg/kg dose group were reduced.Conclusion: PQ401 could inhibit the activity of the larva and influence the immune response of cystic echinococcosis mice.
Background: During the process of the lava of E. granulosus parasite in the intermediate host, the complicated signaling pathway of E. granulosus helps the helminth to evade from the immune system of the host. The insulin receptor signaling pathway, which could regulate the development, growth, glucose metabolism and motility of various parasites, is a crucial pathway in the parasite and becomes anti-helminth drug targets.Method: In order to detect the efficacy and immune response of insulin-like growth factor 1 receptor(IGF- 1R) inhibitor PQ401 on the cystic echinococcosis mice, PQ401 was used to treat the cystic echinococcosis mice, and the efficacy and immune response of PQ401 on the cystic echinococcosis mice were detected.Results: The difference of vesicle wet weight in the PQ401 100 mg/kg dose group and model group was significantly(P<0.05); the inhibitory rate of capsules in the PQ401 100 mg/kg, 50 mg/kg dose group, ABZ group were 53.20%, 40.45%, 57.08%, respectively; The weight of thymus were not different significantly between all groups(P>0.05), while the weight of spleen in PQ401 100 mg/kg dose group and ABZ group was significantly(P<0.05); The content of IL-2, INF-γ and TNF-α in the serum of PQ401 100 mg/kg dose group were elevated than model group and control group, while the content of IL-4 and IL-10 in the serum of PQ401 100 mg/kg dose group were reduced.Conclusion: PQ401 could inhibit the activity of the larva and influence the immune response of cystic echinococcosis mice.
引文