口服氟康唑预防NICU高危患儿真菌感染的剂量研究
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- 英文论文题名：Dose study of fluconazole prophylaxis of fungal infection by oral in Neconatal Intensive Care Unit
- 论文作者：翁小红 ; 王三南 ; 尚尔宁 ; 唐莲
- 英文论文作者：WENG Xiao-hong ; WANG San-nan ; SHANG Er-ning ; TANG Lian ; Department of Pharmacy ; Municipal Hospital of Suzhou ; Department of Neonatesthe ; Municipal Hospital of Suzhou
- 年：2016
- 作者机构：苏州市立医院药学部;苏州市立医院新生儿科;
- 论文关键词：氟康唑 ; 预防 ; NICU ; 真菌感染
- 英文论文关键词：fluconazole ; prophylaxis ; Neonatal intensive care unit(NICU) ; fungal infection
- 会议召开时间：2016-09-27
- 会议录名称：中国药学会第十三届青年药学科研成果交流会论文集
- 语种：中文
- 分类号：R720.597
- 学会代码：YYWS
- 会议名称：中国药学会第十三届青年药学科研成果交流会
- 会议地点：中国江西南昌
- 主办单位：中国药学会
- 学会名称：中国药学会
- 页数：4
- 文件大小：258k
- 原文格式：O
- 会议级别：全国
摘要
目的:评估氟康唑两种常用剂量对NICU内高危患儿真菌感染的预防作用。方法:收集2014年4月~2015年10月苏州市立医院NICU应用氟康唑预防真菌感染的患儿125例,随机分为A、B两组。A组予预防剂量3mg/kg.次、每周两次,B组予预防剂量6mg/kg.次、隔日一次,疗程均为四周,采集相关信息进行统计分析。结果:预防用药后,A组患儿真菌感染率为5.36%,B组患儿真菌感染率为4.35%,两组比较差异无统计学意义(p>0.05);A组患儿转氨酶升高发生率10.7%,B组患儿转氨酶升高发生率18.8%,两组比较差异有统计学意义(p<0.05)。结论:在NICU内对高危患儿使用小剂量、低频次的氟康唑预防真菌感染,是较合适的选择。
Objective To evaluate the effect of prophylaxis administration of fluconazole by oral with two frequentlyused doses in preventing fungal infection in NICU.Methods Collected in April 2014 to October 2015 of Suzhou Municipal Hospital NICU using fluconazole to prevent fungal infection of 126 patients.according to different dosage was divided into A group and B group.collect related information for statistical analysis.Results After preventive medication,A group of children with fungal infection rate was 5.36%,B group of children with fungal infection rate was 4.35%,two groups compare differences had no statistical significance(p > 0.05);A group with 10.7%incidence of transaminase eleations,B group with18.8%incidence of transaminase eleations,comparing the two groups was statistically difference(p < 0.05).Conclusions In NICU for high-risk patients using small doses,low frequency of fluconazole to prevent fungal infection,is a more appropriate choice.
Objective To evaluate the effect of prophylaxis administration of fluconazole by oral with two frequentlyused doses in preventing fungal infection in NICU.Methods Collected in April 2014 to October 2015 of Suzhou Municipal Hospital NICU using fluconazole to prevent fungal infection of 126 patients.according to different dosage was divided into A group and B group.collect related information for statistical analysis.Results After preventive medication,A group of children with fungal infection rate was 5.36%,B group of children with fungal infection rate was 4.35%,two groups compare differences had no statistical significance(p > 0.05);A group with 10.7%incidence of transaminase eleations,B group with18.8%incidence of transaminase eleations,comparing the two groups was statistically difference(p < 0.05).Conclusions In NICU for high-risk patients using small doses,low frequency of fluconazole to prevent fungal infection,is a more appropriate choice.
引文
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[7]Kaufman D,Boyle R,Hazen KC,et al..Twice weeklyfluconazole prophylaxis for prevention of invasive Candidainfection in high-risk infants of<1000 grams birth weight.J Pediatr,2005,147:172-179.
[8]HuangYC,LinTY,LeuHS,etaL.Outbreak of Candida parapsilosis fungemia in neonatal intensive care units:clinicalimplications and genotyping analysis.Infection.1999,27:97-102.
[9]Manzoni P,Stolfi 1,Pugni L,etal.A multicenter,randomized trial of prophylactic fluconazole in preterm neonates.N Engl J Med,2007,356:2483-2495.
[10]郑晓娴.氟康唑不良反应及预防[J].抗感染药学,2011,01:35-38.
[2]FrezzaS,MaggioL,DeCarolisMP,etal.Risk factors for pulmonary candidiasis in preterm infants with a birth weight of less than1250 g[J].Eur J Pediatr,2005,164(2):88-92.
[3]陈超,新生儿真菌感染的诊治[J].中国实用儿科杂志,2011,26(1):3-5.
[4]中华人民共和国卫生部.医院感染诊断标准(试行)[J].中华医学杂志,2001,81(5):314-320.
[5]Kicklighter SD,Springer SC,Cox T,etal.Fluconazole for prophylaxis against candidal rectal colonization in the very low birth weight infant[J].Pediatrics,2001,107(2):293-298.
[6]张金萍,陈超.氟康唑预防极低出生体重儿真菌感染有效性和安全性的Meta分析[J].中华儿科杂志,2009,47(12):891-897.
[7]Kaufman D,Boyle R,Hazen KC,et al..Twice weeklyfluconazole prophylaxis for prevention of invasive Candidainfection in high-risk infants of<1000 grams birth weight.J Pediatr,2005,147:172-179.
[8]HuangYC,LinTY,LeuHS,etaL.Outbreak of Candida parapsilosis fungemia in neonatal intensive care units:clinicalimplications and genotyping analysis.Infection.1999,27:97-102.
[9]Manzoni P,Stolfi 1,Pugni L,etal.A multicenter,randomized trial of prophylactic fluconazole in preterm neonates.N Engl J Med,2007,356:2483-2495.
[10]郑晓娴.氟康唑不良反应及预防[J].抗感染药学,2011,01:35-38.