摘要
The ideal wound dressings should be multi-functional: fighting against acute or chronic infection; maintaining a balanced moisture and gas exchange environment; absorbing extrudates and blood from wounds; and promoting cell proliferation and migration and, thus, wound healing[1]. The antibacterial substances, such as Ag nanoparticles, iodine, and mupirocin, have been added to nanofiber dressings to eliminate infections[2]. Growth factors, vitamins, and minerals, as active compounds in wound healing, have been incorporated into nanofibers to promote normal skin growth and to reduce scar tissue formation[3]. In order to solve the problem of poor antibacterial properties and insufficient mechanical properties of the chitosan/gelatin(CG) nanofibers,we addressed a method for enhancing the antibacterial properties and mechanical properties of CG simultaneously by the addition of graphene oxide-silver(GO-Ag NPs) nanocomposite. Through the method, GO-Ag/CG nanofibers can be obtained successfully via electrospinning.
The ideal wound dressings should be multi-functional: fighting against acute or chronic infection; maintaining a balanced moisture and gas exchange environment; absorbing extrudates and blood from wounds; and promoting cell proliferation and migration and, thus, wound healing[1]. The antibacterial substances, such as Ag nanoparticles, iodine, and mupirocin, have been added to nanofiber dressings to eliminate infections[2]. Growth factors, vitamins, and minerals, as active compounds in wound healing, have been incorporated into nanofibers to promote normal skin growth and to reduce scar tissue formation[3]. In order to solve the problem of poor antibacterial properties and insufficient mechanical properties of the chitosan/gelatin(CG) nanofibers,we addressed a method for enhancing the antibacterial properties and mechanical properties of CG simultaneously by the addition of graphene oxide-silver(GO-Ag NPs) nanocomposite. Through the method, GO-Ag/CG nanofibers can be obtained successfully via electrospinning.
引文
[1]Jayakumar R,Prabaharan M,Sudheesh Kumar PT.;et al.Biotechnol Adv2011;29(3):322-37
[2]Khil M-S,Cha D-I,Kim H-Y.;et al.J Biomed Mater Res B Appl Biomater2003;67B(2):675-79
[3]Weng L,Xie J.Current pharmaceutical design,2015,21(15):1944-1959.