Assessment of a flavone-polysaccharide based prescription for treating duck virus hepatitis
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- 英文论文题名：Assessment of a flavone-polysaccharide based prescription for treating duck virus hepatitis
- 论文作者：Hongxu Du ; Shuaibing Zhang ; Meiyun Song ; Yixuan Wang ; Ling Zeng ; Yun Chen ; Wen Xiong ; Jingjing Yang ; Fangke Yao ; Yi Wu ; Deyun Wang ; Yuanliang Hu ; Jiaguo Liu
- 英文论文作者：Hongxu Du ; Shuaibing Zhang ; Meiyun Song ; Yixuan Wang ; Ling Zeng ; Yun Chen ; Wen Xiong ; Jingjing Yang ; Fangke Yao ; Yi Wu ; Deyun Wang ; Yuanliang Hu ; Jiaguo Liu ; Institute of Traditional Chinese Veterinary Medicine ; College of Veterinary Medicine ; Nanjing Agricultural University
- 年：2016
- 作者机构：Institute of Traditional Chinese Veterinary Medicine,College of Veterinary Medicine,Nanjing Agricultural University;
- 英文论文关键词：Duck hepatitis A virus ; Radix Rehmanniae Recens polysaccharide ; Hypericum japonicum flavone ; Salvia plebeia flavone ; hepatoprotective effect
- 会议召开时间：2016-05-25
- 会议录名称：第七届中国畜牧科技论坛论文集
- 英文会议录名称：Proceeding of the 7th China Animal Husbandry Sci-tech Forum
- 语种：英文
- 分类号：S858.32
- 学会代码：ZGXJ
- 会议名称：第七届中国畜牧科技论坛
- 会议地点：中国重庆
- 主办单位：中国畜牧兽医学会
- 学会名称：中国畜牧兽医学会
- 页数：1
- 文件大小：52k
- 原文格式：O
- 会议级别：全国
摘要
Because polysaccharide and flavone ingredients display good antiviral activity.we developed a flavone/polysaccharide-containing prescription that would be effective against duck viral hepatitis(DVH) and investigated its hepatoprotective effects.Flavones were derived from Hypericum japonicum(HJF)(entire herb of Hypericum japonicum Thunb) and Salvia plebeia(SPF)(entire herb of Salvia plebeia R.Br.),and polysaccharides were derived from Radix Rehmanniae Recens(RRRP)(dried root of Rehmannia glutinosa Libosch).This prescription combination was based on the theory of syndrome differentiation and treatment in traditional Chinese veterinary medicine.In vitro and in vivo experiments were conducted using the three single ingredients compared to the combined HRS prescription to determine their antiduck hepatitis A viral(anti-DHAV) activity.The results showed that all experimental conditions displayed anti-DHAV activity,but the HRS prescription presented the best effect.To further investigate the hepatoprotective effect of the HRS prescription on DHAV-induced hepatic injury,we tested the mortality rate,the hepatic pathological severity score,plasma biochemical indexes of hepatic function,blood DHAV gene expression levels and peroxidation damage evaluation indexes and then analyzed correlations among these indexes.The results demonstrated that the HRS prescription significantly decreased the mortality rate,reduced the severity of hepatic injury,decreased the hepatic pathological severity score,depressed blood DHAV gene expression levels,and returned the indexes of hepatic function and peroxidation almost to a normal level.These results indicate that the HRS prescription confers an outstanding hepatoprotective effect,and we expect that it will be developed into a new candidate antiDHAV drug.
Because polysaccharide and flavone ingredients display good antiviral activity.we developed a flavone/polysaccharide-containing prescription that would be effective against duck viral hepatitis(DVH) and investigated its hepatoprotective effects.Flavones were derived from Hypericum japonicum(HJF)(entire herb of Hypericum japonicum Thunb) and Salvia plebeia(SPF)(entire herb of Salvia plebeia R.Br.),and polysaccharides were derived from Radix Rehmanniae Recens(RRRP)(dried root of Rehmannia glutinosa Libosch).This prescription combination was based on the theory of syndrome differentiation and treatment in traditional Chinese veterinary medicine.In vitro and in vivo experiments were conducted using the three single ingredients compared to the combined HRS prescription to determine their antiduck hepatitis A viral(anti-DHAV) activity.The results showed that all experimental conditions displayed anti-DHAV activity,but the HRS prescription presented the best effect.To further investigate the hepatoprotective effect of the HRS prescription on DHAV-induced hepatic injury,we tested the mortality rate,the hepatic pathological severity score,plasma biochemical indexes of hepatic function,blood DHAV gene expression levels and peroxidation damage evaluation indexes and then analyzed correlations among these indexes.The results demonstrated that the HRS prescription significantly decreased the mortality rate,reduced the severity of hepatic injury,decreased the hepatic pathological severity score,depressed blood DHAV gene expression levels,and returned the indexes of hepatic function and peroxidation almost to a normal level.These results indicate that the HRS prescription confers an outstanding hepatoprotective effect,and we expect that it will be developed into a new candidate antiDHAV drug.
Because polysaccharide and flavone ingredients display good antiviral activity.we developed a flavone/polysaccharide-containing prescription that would be effective against duck viral hepatitis(DVH) and investigated its hepatoprotective effects.Flavones were derived from Hypericum japonicum(HJF)(entire herb of Hypericum japonicum Thunb) and Salvia plebeia(SPF)(entire herb of Salvia plebeia R.Br.),and polysaccharides were derived from Radix Rehmanniae Recens(RRRP)(dried root of Rehmannia glutinosa Libosch).This prescription combination was based on the theory of syndrome differentiation and treatment in traditional Chinese veterinary medicine.In vitro and in vivo experiments were conducted using the three single ingredients compared to the combined HRS prescription to determine their antiduck hepatitis A viral(anti-DHAV) activity.The results showed that all experimental conditions displayed anti-DHAV activity,but the HRS prescription presented the best effect.To further investigate the hepatoprotective effect of the HRS prescription on DHAV-induced hepatic injury,we tested the mortality rate,the hepatic pathological severity score,plasma biochemical indexes of hepatic function,blood DHAV gene expression levels and peroxidation damage evaluation indexes and then analyzed correlations among these indexes.The results demonstrated that the HRS prescription significantly decreased the mortality rate,reduced the severity of hepatic injury,decreased the hepatic pathological severity score,depressed blood DHAV gene expression levels,and returned the indexes of hepatic function and peroxidation almost to a normal level.These results indicate that the HRS prescription confers an outstanding hepatoprotective effect,and we expect that it will be developed into a new candidate antiDHAV drug.
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