有机共轭分子体系的设计、合成与生物应用
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- 英文论文题名：Design of Functional Conjugated Molecules for Biomedical Applications
- 论文作者：王树 ; 刘礼兵 ; 吕凤婷
- 英文论文作者：Shu Wang ; Libing Liu ; Fengting Lv ; Institute of Chemistry ; Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院化学研究所;
- 论文关键词：有机共轭分子 ; 生物识别 ; 细胞成像 ; 疾病治疗
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十一分会：π-共轭材料
- 语种：中文
- 分类号：R318.08
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：54k
- 原文格式：O
- 会议级别：全国
摘要
目前集识别、成像与治疗功能于一体的多功能生物医药体系有望成为重大疾病诊断与治疗的新策略。我们课题组的主要研究内容是设计合成新型有机共轭分子材料,并探索其在生物识别、细胞成像以及疾病治疗领域的新应用。设计合成了系列共轭聚合物荧光探针,研究了它们的生物相容性,筛选了三类具有较低细胞毒性的水溶性聚合物(聚芴、聚噻吩与聚苯撑乙烯)。设计了单一激发波长下多色的共轭聚合物微米粒子,可用于荧光编码与细胞成像。设计构建了兼具细胞成像与抗癌作用的共价连接卟啉基团的水溶性聚噻吩衍生物,光照下该体系产生活性氧,可有效的杀伤肿瘤细胞,同时通过聚合物在细胞中成像位置的不同可实现对活细胞以及凋亡细胞的有效识别。设计并合成了含有季铵盐与PEG侧链的PPV衍生物,实现了对细菌的选择性识别与成像,同时可通过光动力机制杀伤细菌而对细胞没有损伤作用。这些结果为设计基于共轭聚合物的识别、成像与疾病治疗多功能体系提供了新思路。
Water-soluble conjugated polymers(CPs) provide a unique platform for chemical and biological sensors in view of their optical signal amplification effect.In recent years,the CPs integrating recognition,imaging and therapeutic functions have attracted more and more attention.We developed a new technique for preparing multicolor microparticles based on the self-assembly of bacteria and CPs.They can be successfully applied for cell imaging and optical barcoding.A polythiophene-porphyrin dyad was prepared for effectively killing neighboring cells.This multifunctional material that simultaneously provides therapeutic action and image the results provide new strategies for the treatment of various diseases.A cationic poly(p-phenylene vinylene) derivate bearing polyethylene glycol(PEG) side chains was also synthesized and used for selective recognition,imaging and killing of bacteria over mammalian cells.This material exerts a far-reaching impact on the future development of antimicrobial materials.These results exhibit that the multi-functional conjugated polymers are ideal platforms for recognition,imaging and disease therapy.
Water-soluble conjugated polymers(CPs) provide a unique platform for chemical and biological sensors in view of their optical signal amplification effect.In recent years,the CPs integrating recognition,imaging and therapeutic functions have attracted more and more attention.We developed a new technique for preparing multicolor microparticles based on the self-assembly of bacteria and CPs.They can be successfully applied for cell imaging and optical barcoding.A polythiophene-porphyrin dyad was prepared for effectively killing neighboring cells.This multifunctional material that simultaneously provides therapeutic action and image the results provide new strategies for the treatment of various diseases.A cationic poly(p-phenylene vinylene) derivate bearing polyethylene glycol(PEG) side chains was also synthesized and used for selective recognition,imaging and killing of bacteria over mammalian cells.This material exerts a far-reaching impact on the future development of antimicrobial materials.These results exhibit that the multi-functional conjugated polymers are ideal platforms for recognition,imaging and disease therapy.
引文
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[3]Zhu,C;Liu,L.;Yang,Q.;Lv,F.;Wang,S.Chem.Rev.2012,112:4687.
[2]Wang,F.;Liu,Z.;Wang,B.;Feng,L.;Liu,L.;Lv,F.;Wang,Y.;Wang,S.Angew.Chem.Int.Ed.2014,53:424.
[3]Zhu,C;Liu,L.;Yang,Q.;Lv,F.;Wang,S.Chem.Rev.2012,112:4687.