基于多爪脲基功能单体分子的棉酚分子印迹聚合物的设计
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- 英文论文题名：The design of gossypol molecularly imprinted polymers based on multi-armed urea functional monomer
- 论文作者：王璐璐 ; 郅轲轲 ; 姜莹芳 ; 张学敏 ; 张乐涛 ; 张亚刚
- 英文论文作者：Lulu WANG ; Keke ZHI ; Yingfang JIANG ; Xueming ZHANG ; Letao ZHANG ; Yagang ZHANG ; Xinjiang Technical Institute of Physics and Chemistry ; The Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; Xinjiang Institute of Engineering
- 年：2016
- 作者机构：中国科学院新疆理化技术研究所;中国科学院大学;新疆工程学院化学与环境工程系;
- 论文关键词：分子印迹 ; 功能单体合成 ; 棉酚 ; 识别位点多样性
- 英文论文关键词：molecular imprinting ; functional monomer preparation ; gossypol ; binding sites heterogenerity
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
- 语种：中文
- 分类号：O631.5
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：223k
- 原文格式：D
- 会议级别：全国
摘要
为解决制备分子印迹聚合物过程中非特异性识别位点大量生成~([1])的问题,设计了基于脲基的具有自聚集效应的功能单体分子。同时设计了基于苯环的~([2-4])带有灵活三爪官能团的分子受体,并使其键接可聚合的双键,作为功能单体分子,以棉酚为模板分子,以乙二醇二甲基丙烯酸酯为交联剂,采用自由基引发聚合制备了棉酚分子印迹聚合物,对棉酚的吸附容量达62 mg/g。结果表明:通过所设计的模板激活分子印迹策略可以有效减少分子印迹聚合物中非特异性识别位点的数量,提高分子印迹的选择性。
In order to address issue of binding sites heterogenerity in molecular imprinting, Urea based functional monomer which can undergo self-aggregate was designed. A tripodal bezene based molecular receptor feature multiple flexible "arms" that can wrap around template molecule and form multiple non-covalent interactions was prepared. The receptor was derivatized with vinyl groups and used as functional monomers,gossypol was used as template molecule, ethyleneglycol dimethacrylate was used as crosslinking agent. Molecularly imprinted polymers were prepared via free radical polymerization. 62 mg/g adsorption capacity for gossypol can be achieved. By using designed template activated molecular imprinting strategy, the specificity and selectivity for gossypol can be significantly improved by reducing number of non-specific binding sites.
In order to address issue of binding sites heterogenerity in molecular imprinting, Urea based functional monomer which can undergo self-aggregate was designed. A tripodal bezene based molecular receptor feature multiple flexible "arms" that can wrap around template molecule and form multiple non-covalent interactions was prepared. The receptor was derivatized with vinyl groups and used as functional monomers,gossypol was used as template molecule, ethyleneglycol dimethacrylate was used as crosslinking agent. Molecularly imprinted polymers were prepared via free radical polymerization. 62 mg/g adsorption capacity for gossypol can be achieved. By using designed template activated molecular imprinting strategy, the specificity and selectivity for gossypol can be significantly improved by reducing number of non-specific binding sites.
引文
[1]Umpleby II,R.J.;Baxter,S.C.;Rampey,A.M.;Rushton,G.T.;Chen,Y.;Shimizu,K.D.Characterization of the heterogeneous binding site affinity distributions in molecularly imprinted polymers.Journal of Chromatography B.2004,1:141-149.
[2].Wright,A.T.;Anslyn,E.V.;Differential receptor arrays and assays for solution-based molecular recognition.Chem.Soc.Rev.2006,35:14-28.
[3].Vacca,A.;Nativi,C.;Cacciarini,M.;Pergoli,R.;Roelens,S.A new tripodal receptor for molecular recognition of monosaccharides.A paradigm for assessing glycoside binding affinities and selectivities by 1 H NMRspectroscopy.J.Am.Chem.Soc.2004,126:16456-16465.
[4].Hall,A.J.;Lanza-Sellergren,F.;Manesiotis,P;Sellergren,B.Non-covalent imprinting of phosphorous esters.Anal.Chim.Acta.2005,538:9-14.
[2].Wright,A.T.;Anslyn,E.V.;Differential receptor arrays and assays for solution-based molecular recognition.Chem.Soc.Rev.2006,35:14-28.
[3].Vacca,A.;Nativi,C.;Cacciarini,M.;Pergoli,R.;Roelens,S.A new tripodal receptor for molecular recognition of monosaccharides.A paradigm for assessing glycoside binding affinities and selectivities by 1 H NMRspectroscopy.J.Am.Chem.Soc.2004,126:16456-16465.
[4].Hall,A.J.;Lanza-Sellergren,F.;Manesiotis,P;Sellergren,B.Non-covalent imprinting of phosphorous esters.Anal.Chim.Acta.2005,538:9-14.