面向无创神经调控应用的超声时间反演经颅聚焦方法的仿真研究
详细信息 查看官网全文
- 英文论文题名：The simulation for non-invasive neural regulation applied transcranial focused ultrasound based on time reversal
- 论文作者：姜翔飞 ; 杨新新 ; 肖杨 ; 蔡飞燕 ; 王丛知 ; 郑海荣
- 英文论文作者：JIANG Xiang-fei ; YANG Xin-xin ; XIAO Yang ; CAI Fei-yan ; WANG Cong-zhi ; ZHENG Hai-rong ; Paul C.Lauterbur Research Center for Biomedical Imaging ; Institute of Biomedical and Health Engineering ; Shenzhen Institutes of Advanced Technology ; Chinese Academy of Sciences ; Northeastern University ; Sino-Dutch Biomedical and Information Engineering School
- 年：2016
- 作者机构：中国科学院深圳先进技术研究院,生物医学与健康工程研究所,保罗·C·劳特伯生物医学成像研究中心;东北大学中荷生物医学与信息工程学院;
- 论文关键词：经颅超声聚焦 ; K-wave ; 时间反演
- 英文论文关键词：transcranial ultrasound focus ; K-wave ; time reversal
- 会议召开时间：2016-10-28
- 会议录名称：2016年全国声学学术会议论文集
- 语种：中文
- 分类号：R445.1;TB559
- 学会代码：OGSM
- 会议名称：2016年全国声学学术会议
- 会议地点：中国湖北武汉
- 主办单位：中国声学学会
- 学会名称：中国声学学会
- 页数：4
- 文件大小：580k
- 原文格式：D
- 会议级别：全国
摘要
超声无创神经调控技术近年来已经成为医学超声领域新的研究热点,其通过低强度聚焦超声作用于脑部的特定区域,实现对该部位神经核团的精确刺激,诱发其产生神经活动和相应反应。但要实现该方法在非人灵长类甚至人类上的应用,一个必须首先解决的问题就是如何克服颅骨对超声聚焦效果产生的不利影响。本文利用开源声学仿真工具K-wave toolbox,进行了基于时间反演方法的2D超声经颅聚焦仿真,研究不同换能器阵元数目和不同超声发射频率等因素对超声经颅聚焦效果的影响。此外,我们还探讨了利用时间反演实现多点聚焦和不规则形状区域聚焦的可行性。
Ultrasonic non-invasive Neuromodulation technology in recent years has become a new focus of research in the field of medical ultrasound, it is through the low-intensity focused ultrasound in a specific area of the brain, stimulating the precise site of the nucleus, which produces evoked neural activity and corresponding reaction. But to implement this method in non-human primates and even humans, the problem must be solved is how to overcome the adverse effect of caused by the skull when ultrasound focused. Hence, the paper use K-wave tool box(the open source software package) realizes the simulation of transcranial ultrasound focus in 2D.In this paper, we study the factors of the detector with the different number of array,the virtual source with the different depth of focus and the frequency and the contrast of the multipoint focus and the continuous area of focus on the effect of time reversal in the simulation research and analyze these factors how to affect the results on the transcranial ultrasound focus based on time reversal. In addition, we study the feasibility by multi-point focusing and irregularly shaped areas focusing based on time reversal.
Ultrasonic non-invasive Neuromodulation technology in recent years has become a new focus of research in the field of medical ultrasound, it is through the low-intensity focused ultrasound in a specific area of the brain, stimulating the precise site of the nucleus, which produces evoked neural activity and corresponding reaction. But to implement this method in non-human primates and even humans, the problem must be solved is how to overcome the adverse effect of caused by the skull when ultrasound focused. Hence, the paper use K-wave tool box(the open source software package) realizes the simulation of transcranial ultrasound focus in 2D.In this paper, we study the factors of the detector with the different number of array,the virtual source with the different depth of focus and the frequency and the contrast of the multipoint focus and the continuous area of focus on the effect of time reversal in the simulation research and analyze these factors how to affect the results on the transcranial ultrasound focus based on time reversal. In addition, we study the feasibility by multi-point focusing and irregularly shaped areas focusing based on time reversal.
引文
[1]Aubry JF,Tanter M,Pernot M,Thomas JL,Fink M.(2003)Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans.Journal of the Acoustical Society of America 113(1):84-93.
[2]Fink M.(1992)Time reversal of ultrasonic fields.I.Basic principles.IEEE Transactions on Ultrasonics,Ferroelectrics and Frequency Control 39:555–566.
[3]Marquet F,Pernot M,Aubry JF,Montaldo G,Marsac L,Tanter M,Fink M(2009)Non-invasive transcranial ultrasound therapy based on a 3D CT scan:Protocol validation and in vitro results.Physics in Medicine and Biology 54:2597–613.
[4]Treeby B E and Cox B T 2010 k-Wave:MATLAB toolbox for the simulation and reconstruction of photoacoustic wave-fields J.Biomed.Opt.15 021314.
[5]Cox B T and Beard P C 2009 Modeling photoacoustic propagation in tissue using k-space techniques Photoacoustic Imaging and Spectroscopy ed L V Wang(Boca Raton,FL:CRC Press)pp25-3
[2]Fink M.(1992)Time reversal of ultrasonic fields.I.Basic principles.IEEE Transactions on Ultrasonics,Ferroelectrics and Frequency Control 39:555–566.
[3]Marquet F,Pernot M,Aubry JF,Montaldo G,Marsac L,Tanter M,Fink M(2009)Non-invasive transcranial ultrasound therapy based on a 3D CT scan:Protocol validation and in vitro results.Physics in Medicine and Biology 54:2597–613.
[4]Treeby B E and Cox B T 2010 k-Wave:MATLAB toolbox for the simulation and reconstruction of photoacoustic wave-fields J.Biomed.Opt.15 021314.
[5]Cox B T and Beard P C 2009 Modeling photoacoustic propagation in tissue using k-space techniques Photoacoustic Imaging and Spectroscopy ed L V Wang(Boca Raton,FL:CRC Press)pp25-3