LPS诱导奶牛子宫内膜细胞TLR4信号传导通路研究进展
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- 英文论文题名：Progress on LPS induced TLR4 signaling pathway in bovine endometrial cells
- 论文作者：燕晓晓 ; 王军 ; 吕文发
- 英文论文作者：YAN Xiao-xiao ; WANG Jun ; LYU Wen-fa ; College of Animal Science and Technology ; Jilin Agricultural University
- 年：2016
- 作者机构：吉林农业大学动物科技学院;
- 论文关键词：奶牛子宫内膜炎 ; LPS ; TLR4信号通路 ; 炎性因子
- 英文论文关键词：cow endometritis ; LPS ; TLR4 signaling pathway ; inflammatory factors
- 会议召开时间：2016-11-04
- 会议录名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会论文集
- 语种：中文
- 分类号：S858.23
- 学会代码：ZGXJ
- 会议名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会
- 会议地点：中国山东青岛
- 主办单位：中国畜牧兽医学会动物微生态学分会
- 学会名称：中国畜牧兽医学会
- 页数：3
- 文件大小：269k
- 原文格式：O
- 会议级别：全国
摘要
子宫内膜炎是奶牛产后细菌感染子宫而引起的产科疾病,严重影响奶牛业的健康发展。革兰氏阴性细菌中的大肠杆菌是目前已知引起奶牛子宫内膜炎的主要致病菌,细菌脂多糖(lipopolysaccharide,LPS)是革兰氏阴性细菌细胞壁的重要组成成分,也是近年来研究奶牛子宫内膜炎发病机制的重要诱导物。本文综述了LPS、TOLL样受体家族(Toll-like receptors,TLRs)及炎性因子,初步剖析了LPS诱导的炎症反应信号传导通路-TLR4信号通路,为奶牛子宫内膜炎的研究提供参考。
Postpartum endometritis in cattle is an obstetric disease caused by bacterial infection,which is of economic importance since it negatively impacts on the dairy industry.Gram negative bacteria of Escherichia coli is the main pathogens currently known to cause cow endometritis and bacterial lipopolysaccharide(LPS) is a major component of the cell wall of gram negative bacteria and recently,also reported as an important inducer of cow endometritis pathogenesis.This paper reviews the LPS,toll like receptor family(Toll-like receptors,TLRs) and inflammatory factors as well as preliminary analysis of the LPS induced inflammatory response signaling pathway-TLR4 signaling pathway in order to provide reference for the study of cow endometritis.
Postpartum endometritis in cattle is an obstetric disease caused by bacterial infection,which is of economic importance since it negatively impacts on the dairy industry.Gram negative bacteria of Escherichia coli is the main pathogens currently known to cause cow endometritis and bacterial lipopolysaccharide(LPS) is a major component of the cell wall of gram negative bacteria and recently,also reported as an important inducer of cow endometritis pathogenesis.This paper reviews the LPS,toll like receptor family(Toll-like receptors,TLRs) and inflammatory factors as well as preliminary analysis of the LPS induced inflammatory response signaling pathway-TLR4 signaling pathway in order to provide reference for the study of cow endometritis.
引文
[1].Salilew-Wondim D,Ibrahim S,Gebremedhn S,Tesfaye D,Heppelmann M,Bollwein H,et al.Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile[J].BMC genomics.2016;17(1):218.
[2].蔡明周.奶牛子宫内膜炎的临床诊治分析[J].畜牧兽医科技信息.2016(01):44-5.
[3].Ajevar G,Muthu S,Sarkar M,Kumar H,Das GK,Krishnaswamy N.Transcriptional profile of endometrial TLR4 and 5 genes during the estrous cycle and uterine infection in the buffalo(Bubalus bubalis)[J].Veterinary research communications.2014;38(2):171-6.
[4].Molteni M,Gemma S,Rossetti C.The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation[J].2016;2016:6978936.
[5].Cronin JG,Turner ML,Goetze L,Bryant CE,Sheldon IM.Toll-like receptor 4 and MYD88-dependent signaling mechanisms of the innate immune system are essential for the response to lipopolysaccharide by epithelial and stromal cells of the bovine endometrium[J].Biology of reproduction.2012;86(2):51.
[6].Romero A,Novoa B,Figueras A.Cell mediated immune response of the Mediterranean sea urchin Paracentrotus lividus after PAMPs stimulation[J].Developmental and comparative immunology.2016;62:29-38
[2].蔡明周.奶牛子宫内膜炎的临床诊治分析[J].畜牧兽医科技信息.2016(01):44-5.
[3].Ajevar G,Muthu S,Sarkar M,Kumar H,Das GK,Krishnaswamy N.Transcriptional profile of endometrial TLR4 and 5 genes during the estrous cycle and uterine infection in the buffalo(Bubalus bubalis)[J].Veterinary research communications.2014;38(2):171-6.
[4].Molteni M,Gemma S,Rossetti C.The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation[J].2016;2016:6978936.
[5].Cronin JG,Turner ML,Goetze L,Bryant CE,Sheldon IM.Toll-like receptor 4 and MYD88-dependent signaling mechanisms of the innate immune system are essential for the response to lipopolysaccharide by epithelial and stromal cells of the bovine endometrium[J].Biology of reproduction.2012;86(2):51.
[6].Romero A,Novoa B,Figueras A.Cell mediated immune response of the Mediterranean sea urchin Paracentrotus lividus after PAMPs stimulation[J].Developmental and comparative immunology.2016;62:29-38