RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect
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- 英文论文题名：RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect
- 论文作者：Chen-Song Zhang ; Qi Liu ; Mengqi Li ; Shu-Yong Lin ; Yongying Peng ; Di Wu ; Terytty Yang Li ; Qiang Fu ; Weiping Jia ; Xinjun Wang ; Teng Ma ; Yue Zong ; Jiwen Cui ; Chengfei Pu ; Guili Lian ; Huiling Guo ; Zhiyun Ye ; Sheng-Cai Lin
- 英文论文作者：Chen-Song Zhang ; Qi Liu ; Mengqi Li ; Shu-Yong Lin ; Yongying Peng ; Di Wu ; Terytty Yang Li ; Qiang Fu ; Weiping Jia ; Xinjun Wang ; Teng Ma ; Yue Zong ; Jiwen Cui ; Chengfei Pu ; Guili Lian ; Huiling Guo ; Zhiyun Ye ; Sheng-Cai Lin ; State Key Laboratory of Cellular Stress Biology ; Innovation Center for Cell Signaling Network ; School of Life Sciences ; Xiamen University ; Department of Urology ; Shanghai Jiao Tong University Affiliated Sixth People's Hospital ; Department of Endocrinology and Metabolism ; Shanghai Jiao Tong University Affiliated Sixth People's Hospital ; Department of Urology ; Zhongshan Hospital ; Xiamen University
- 年：2016
- 作者机构：State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences,Xiamen University;Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital;Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital;Department of Urology, Zhongshan Hospital, Xiamen University;
- 英文论文关键词：RHOBTB3 ; HIF ; PHD ; VHL ; ubiquitination ; the Warburg effect
- 会议召开时间：2016-10-20
- 会议录名称：中国生物化学与分子生物学会2016年全国学术会议论文集
- 语种：英文
- 分类号：R730.2
- 学会代码：IGSS
- 会议名称：中国生物化学与分子生物学会2016年全国学术会议
- 会议地点：中国浙江杭州
- 主办单位：中国生物化学与分子生物学会
- 学会名称：中国生物化学与分子生物学会
- 页数：2
- 文件大小：6865k
- 原文格式：D
- 会议级别：全国
摘要
<正>Hypoxia-inducible factors(HIFs)are master regulators of adaptive responses to low oxygen,and theirα-subunits are rapidly degraded through the ubiquitination-dependent proteasomal pathway after prior hydroxylation.Aberrant accumulation or activation of HIFs is closely linked to many types of cancer.However,how hydroxylation of HIFαand its channeling to
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