大豆磷脂酰聚乙二醇单甲醚2000的制备及性能研究
详细信息 查看官网全文
- 英文论文题名：The Preparation and Performance Study of Soybean Phosphatidyl Methoxy Polyethylene Glycol 2000 Ester
- 论文作者：陈圳 ; 卫延安
- 英文论文作者：Chen Zhen ; Wei Yan'an ; Institute of Chemical Industry ; Nanjing University of Science and Technology
- 年：2016
- 作者机构：南京理工大学化工学院;
- 论文关键词：大豆磷脂 ; 聚乙二醇单甲醚2000 ; 大豆磷脂酰聚乙二醇单甲醚2000
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十一分会：胶体与界面化学
- 语种：中文
- 分类号：O632.31
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十一分会 ; 胶体与界面化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：283k
- 原文格式：D
- 会议级别：全国
摘要
以大豆磷脂为原料,先制备成为反应活性较高的大豆磷脂酸钠,将其与活化的聚乙二醇单甲醚即聚乙二醇单甲醚2000对甲苯磺酸酯(mPEG_(2000)-OTs)反应制备了大豆磷脂酰聚乙二醇单甲醚2000(SP-mPEG_(2000))。实验得到最优的制备工艺为:以65mg NaH处理大豆磷脂得到大豆磷脂酸钠,m(大豆磷脂酸钠):m(mPEG_(2000)-OTs)=0.45:1,反应时间为4h,反应温度为90℃,在最佳合成条件下转化率为71.2%,产物为淡黄色固体。产物结构经~1H-NMR和IR表征,表明已成功制备得到SP-mPEG_(2000)。该法的优点是反应条件温和,同时能够将大豆磷脂中的各种组分均进行充分利用,在前人基础上提高利用率。SP-mPEG_(2000)水溶液临界胶束浓度为0.5 g.L~(-1),此时表面张力(γ_(CMC))为42 mN·m~(-1)。通过SP-mPEG_(2000)对正己烷和水形成的乳状液的稳定性表征,表明产物的动力学稳定性优于大豆粉末磷脂。
With soybean phospholipid as raw material,first,it was prepared into sodium soy phospholipids of high reactive activity and then reacted with activated monomethoxypolyethylene glycol,namely,monomethoxypolyethylene glycol 2000 tosylate(mPEG_(2000)-OTs) and soybean phosphatidyl methoxy polyethylene glycol 2000 esters(SP-mPEG_(2000) were synthesized.Optimal experiments of preparation were as follows:soybean phospholipid was treated with 65 mg NaH to obtain sodium soy phospholipids,m(sodium soy phospholipids):m(mPEG2000-OTs) = 0.45:1,reaction time was 4 h and the reaction temperature was 90 ℃,under optimal conditions the conversion was 71.2%,and the product as a pale yellow solid.The product structure was characterized by ~1H-NMR and IR,which indicating the successful preparation of SP-mPEG_(2000).The critical micelle concentration of SP-mPEG_(2000) is 0.5 g·L~(-1) by surface tension(γ_(CMC)) is 42 mN·m~(-1),The kinetic stability of SP-mPEG_(2000) was characterized by emulsifying power of n-hexane and water,which indicated that kinetic stability of the product is superior to soy lecithin powder.
With soybean phospholipid as raw material,first,it was prepared into sodium soy phospholipids of high reactive activity and then reacted with activated monomethoxypolyethylene glycol,namely,monomethoxypolyethylene glycol 2000 tosylate(mPEG_(2000)-OTs) and soybean phosphatidyl methoxy polyethylene glycol 2000 esters(SP-mPEG_(2000) were synthesized.Optimal experiments of preparation were as follows:soybean phospholipid was treated with 65 mg NaH to obtain sodium soy phospholipids,m(sodium soy phospholipids):m(mPEG2000-OTs) = 0.45:1,reaction time was 4 h and the reaction temperature was 90 ℃,under optimal conditions the conversion was 71.2%,and the product as a pale yellow solid.The product structure was characterized by ~1H-NMR and IR,which indicating the successful preparation of SP-mPEG_(2000).The critical micelle concentration of SP-mPEG_(2000) is 0.5 g·L~(-1) by surface tension(γ_(CMC)) is 42 mN·m~(-1),The kinetic stability of SP-mPEG_(2000) was characterized by emulsifying power of n-hexane and water,which indicated that kinetic stability of the product is superior to soy lecithin powder.
引文
[1]Greenwald R B.PEG drugs:an overview.Journal of Controlled Release Official Journal of the Controlled Release Society,2001,74(1-3):159.
[2]陈庆春,邓慧宇,马燕明.聚乙二醇在新材料制备中的作用及其机理.日用化学工业,2002,32(5):35.
[2]陈庆春,邓慧宇,马燕明.聚乙二醇在新材料制备中的作用及其机理.日用化学工业,2002,32(5):35.