GABA mediates interleukin-17 expression during intestinal bacterial infection
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- 英文论文题名：GABA mediates interleukin-17 expression during intestinal bacterial infection
- 论文作者：Ren wenkai ; Liu gang ; Tan bie ; Li tiejun ; Wu guoyao ; Philip R.Hardwidge ; Yin yulong
- 英文论文作者：Ren wenkai ; Liu gang ; Tan bie ; Li tiejun ; Wu guoyao ; Philip R.Hardwidge ; Yin yulong ; Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology ; Institute of Subtropical Agriculture ; The Chinese Academy of Sciences ; University of the Chinese Academy of Sciences ; Department of Animal Science ; Texas A&M University ; 2471 TAMU ; College Station ; Department of Diagnostic Medicine/Pathobiology ; Kansas State University
- 年：2016
- 作者机构：Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology,Institute of Subtropical Agriculture,The Chinese Academy of Sciences;University of the Chinese Academy of Sciences;Department of Animal Science,Texas A&M University,2471 TAMU,College Station;Department of Diagnostic Medicine/Pathobiology,Kansas State University;
- 英文论文关键词：GABA ; IL-17 ; mTOR ; enterotoxigenic Escherichia coli ; Lactococcus lactis
- 会议召开时间：2016-05-25
- 会议录名称：第七届中国畜牧科技论坛论文集
- 英文会议录名称：Proceeding of the 7th China Animal Husbandry Sci-tech Forum
- 语种：英文
- 分类号：S852.61
- 学会代码：ZGXJ
- 会议名称：第七届中国畜牧科技论坛
- 会议地点：中国重庆
- 主办单位：中国畜牧兽医学会
- 学会名称：中国畜牧兽医学会
- 页数：18
- 文件大小：4535k
- 原文格式：O
- 会议级别：全国
摘要
Interleukin-17(IL-17) has a central role against bacterial pathogens in the intestine.However,the mechanism by which intestinal IL-17 expression is triggered during bacterial infection is poorly understood.Here,we found enterotoxigenic Escherichia coli(ETEC)increases intestinal IL-17 expression through γ-aminobutyric acid(GABA) signaling,which largely depends on intestinal GABA-producing Lactococcus lactis subsp.lactis.GABA promotes intestinal IL-17 expression in the context of ETEC infection through enhancing mTOR signaling,which activated ribosomal protein S6 kinase 1(S6K1)-early growth response protein 2(EGR2)-growth factor independent 1 transcription repressor(GFI1) pathway.GABAmTOR signaling also affected IL-17 expression in response to Citrobacter rodentium infection and in drug-induced models of intestinal inflammation.Furthermore,a deficiency of slc6a13(GABA transporter 2) in mice promotes Th17 responses against intestinal infection.These findings highlight the importance of GABA-mTOR signaling in intestinal IL-17 expression during intestinal infection,and indicate the potential of GABA signaling in IL-17-associated intestinal diseases.
Interleukin-17(IL-17) has a central role against bacterial pathogens in the intestine.However,the mechanism by which intestinal IL-17 expression is triggered during bacterial infection is poorly understood.Here,we found enterotoxigenic Escherichia coli(ETEC)increases intestinal IL-17 expression through γ-aminobutyric acid(GABA) signaling,which largely depends on intestinal GABA-producing Lactococcus lactis subsp.lactis.GABA promotes intestinal IL-17 expression in the context of ETEC infection through enhancing mTOR signaling,which activated ribosomal protein S6 kinase 1(S6K1)-early growth response protein 2(EGR2)-growth factor independent 1 transcription repressor(GFI1) pathway.GABAmTOR signaling also affected IL-17 expression in response to Citrobacter rodentium infection and in drug-induced models of intestinal inflammation.Furthermore,a deficiency of slc6a13(GABA transporter 2) in mice promotes Th17 responses against intestinal infection.These findings highlight the importance of GABA-mTOR signaling in intestinal IL-17 expression during intestinal infection,and indicate the potential of GABA signaling in IL-17-associated intestinal diseases.
Interleukin-17(IL-17) has a central role against bacterial pathogens in the intestine.However,the mechanism by which intestinal IL-17 expression is triggered during bacterial infection is poorly understood.Here,we found enterotoxigenic Escherichia coli(ETEC)increases intestinal IL-17 expression through γ-aminobutyric acid(GABA) signaling,which largely depends on intestinal GABA-producing Lactococcus lactis subsp.lactis.GABA promotes intestinal IL-17 expression in the context of ETEC infection through enhancing mTOR signaling,which activated ribosomal protein S6 kinase 1(S6K1)-early growth response protein 2(EGR2)-growth factor independent 1 transcription repressor(GFI1) pathway.GABAmTOR signaling also affected IL-17 expression in response to Citrobacter rodentium infection and in drug-induced models of intestinal inflammation.Furthermore,a deficiency of slc6a13(GABA transporter 2) in mice promotes Th17 responses against intestinal infection.These findings highlight the importance of GABA-mTOR signaling in intestinal IL-17 expression during intestinal infection,and indicate the potential of GABA signaling in IL-17-associated intestinal diseases.
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