Using biochemical knowledge of cytochrome P450 and other enzymes in prediction of drug metabolism and toxicity
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- 英文论文题名：Using biochemical knowledge of cytochrome P450 and other enzymes in prediction of drug metabolism and toxicity
- 论文作者：F.Peter Guengerich
- 英文论文作者：F.Peter Guengerich ; Department of Biochemistry Vanderbilt University School of Medicine
- 年：2016
- 作者机构：Department of Biochemistry Vanderbilt University School of Medicine;
- 会议召开时间：2016-10-20
- 会议录名称：中国生物化学与分子生物学会2016年全国学术会议论文集
- 语种：英文
- 分类号：R96
- 学会代码：IGSS
- 会议名称：中国生物化学与分子生物学会2016年全国学术会议
- 会议地点：中国浙江杭州
- 主办单位：中国生物化学与分子生物学会
- 学会名称：中国生物化学与分子生物学会
- 页数：2
- 文件大小：6865k
- 原文格式：D
- 会议级别：全国
摘要
<正>Cytochrome P450(P450,CYP)enzymes are remarkable in light of their great diversity of substrates.They are the most versatile catalysts known,involved in>95%of oxidations of chemicals(1).These oxidations are prominent in the metabolism of drugs,with P450s contributing in 75%of the enzymatic transformations of small molecule drugs.These reactions are important in the inter-individual variability in drug metabolism
引文
1.Rendic,S.,and Guengerich,F.P.(2015)Survey of Human Oxidoreductases and Cytochrome P450Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals.Chem.Res.Toxicol.28,38-42
2.Brodney,M.A.,Beck,E.M.,Butler,C.R.,Barreiro,G.,Johnson,E.F.,Riddell,D.,Parris,K.,Nolan,C.E.,Fan,Y.,Atchison,K.,Gonzales,C.,Robshaw,A.E.,Doran,S.D.,Bundesmann,M.W.,Buzon,L.,Dutra,J.,Henegar,K.,La Chapelle,E.,Hou,X.,Rogers,B.N.,Pandit,J.,Lira,R.,Martinez-Alsina,L.,Mikochik,P.,Murray,J.C.,Ogilvie,K.,Price,L.,Sakya,S.M.,Yu,A.,Zhang,Y.,and O'Neill,B.T.(2015)Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 Inhibitors.J.Med.Chem.58,3223-3252
3.Kaur,P.,Chamberlin,A.R.,Poulos,T.L.,and Sevrioukova,I.F.(2016)Structure-based inhibitor design for evaluation of a CYP3A4 pharmacophore model.J.Med.Chem.59,4210-4220
4.Guengerich,F.P.(2016)Intersection of roles of cytochrome P450 enzymes with xenobiotic and endogenous substrates.Relevance to toxicity and drug interactions.Chem.Res.Toxicol.30,in press.
5.Guengerich,F.P.,Humphreys,W.G.,and Will,Y.(2016)Toxicology strategies for drug discoverypresent and future:Introduction.Chem.Res.Toxicol.29,437
2.Brodney,M.A.,Beck,E.M.,Butler,C.R.,Barreiro,G.,Johnson,E.F.,Riddell,D.,Parris,K.,Nolan,C.E.,Fan,Y.,Atchison,K.,Gonzales,C.,Robshaw,A.E.,Doran,S.D.,Bundesmann,M.W.,Buzon,L.,Dutra,J.,Henegar,K.,La Chapelle,E.,Hou,X.,Rogers,B.N.,Pandit,J.,Lira,R.,Martinez-Alsina,L.,Mikochik,P.,Murray,J.C.,Ogilvie,K.,Price,L.,Sakya,S.M.,Yu,A.,Zhang,Y.,and O'Neill,B.T.(2015)Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 Inhibitors.J.Med.Chem.58,3223-3252
3.Kaur,P.,Chamberlin,A.R.,Poulos,T.L.,and Sevrioukova,I.F.(2016)Structure-based inhibitor design for evaluation of a CYP3A4 pharmacophore model.J.Med.Chem.59,4210-4220
4.Guengerich,F.P.(2016)Intersection of roles of cytochrome P450 enzymes with xenobiotic and endogenous substrates.Relevance to toxicity and drug interactions.Chem.Res.Toxicol.30,in press.
5.Guengerich,F.P.,Humphreys,W.G.,and Will,Y.(2016)Toxicology strategies for drug discoverypresent and future:Introduction.Chem.Res.Toxicol.29,437