Prognostic value of Bmi-1 expression in human epithelial ovarian cancer
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- 英文论文题名：Prognostic value of Bmi-1 expression in human epithelial ovarian cancer
- 论文作者：Xu Yun ; Chen Lujun ; Rui Xiaohui ; Xu Bin ; Jiang Xiping ; Huang Yaqing ; Jiang Guohua ; Guo Caixia ; Shao Yingjie ; Li Xiaodong ; Zhou You ; Zheng Xiao ; Jiang Jingting
- 英文论文作者：Xu Yun ; Chen Lujun ; Rui Xiaohui ; Xu Bin ; Jiang Xiping ; Huang Yaqing ; Jiang Guohua ; Guo Caixia ; Shao Yingjie ; Li Xiaodong ; Zhou You ; Zheng Xiao ; Jiang Jingting ; Department of Tumor Biological Treatment ; Jiangsu Engineering Research Center for Tumor Immunotherapy ; Institute of Cell Therapy ; Soochow University ; Department of Gynaecology ; The Third Affiliated Hospital of Soochow University
- 年：2016
- 作者机构：Department of Tumor Biological Treatment;Jiangsu Engineering Research Center for Tumor Immunotherapy;Institute of Cell Therapy,Soochow University;Department of Gynaecology,The Third Affiliated Hospital of Soochow University;
- 英文论文关键词：Bmi-1 ; Epithelial ovarian cancer ; Metastasis ; Prognosis
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会摘要汇编
- 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R737.31
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：987k
- 原文格式：D
- 会议级别：全国
摘要
Objectives: The aim of this study was to explore the role of Bmi-1 as a prognostic biomarker in epithelial ovarian cancer(EOC). Methods: Bmi-1 expression was assessed in 82 EOC tissues and 10 control tissues using immunochemistry. Statistical analyses were performed to investigate the associations between Bmi-1 expression and clinicopathological characteristics as well as survival time. Results: Positive Bmi-1 expression was detected in 87.8%(72/82) of EOC tissues and significantly higher expression of Bmi-1 was observed in EOC than in benign ovarian tumor tissues(P < 0.01).Cox regression analyses revealed that higher Bmi-1 level was significantly associated with poorer overall survival in patients with EOC(mean overall survival, 45.4 vs. 69.3 months) than those with benign ovarian tumors. Moreover, high Bmi-1 expression was an independent predictor for prognosis(HR= 2.212, 95% CI = 1.091-4.482, P < 0.05) in EOC patients. This was further confirmed by survival analysis based on Bmi-1 levels from a large patient cohort(1582 cases) derived from The Cancer Genome Atlas(TCGA) and Gene Expression Omnibus(GEO). Conclusions: High Bmi-1 expression is positively associated with metastastic disease and poor prognosis in EOC.
Objectives: The aim of this study was to explore the role of Bmi-1 as a prognostic biomarker in epithelial ovarian cancer(EOC). Methods: Bmi-1 expression was assessed in 82 EOC tissues and 10 control tissues using immunochemistry. Statistical analyses were performed to investigate the associations between Bmi-1 expression and clinicopathological characteristics as well as survival time. Results: Positive Bmi-1 expression was detected in 87.8%(72/82) of EOC tissues and significantly higher expression of Bmi-1 was observed in EOC than in benign ovarian tumor tissues(P < 0.01).Cox regression analyses revealed that higher Bmi-1 level was significantly associated with poorer overall survival in patients with EOC(mean overall survival, 45.4 vs. 69.3 months) than those with benign ovarian tumors. Moreover, high Bmi-1 expression was an independent predictor for prognosis(HR= 2.212, 95% CI = 1.091-4.482, P < 0.05) in EOC patients. This was further confirmed by survival analysis based on Bmi-1 levels from a large patient cohort(1582 cases) derived from The Cancer Genome Atlas(TCGA) and Gene Expression Omnibus(GEO). Conclusions: High Bmi-1 expression is positively associated with metastastic disease and poor prognosis in EOC.
Objectives: The aim of this study was to explore the role of Bmi-1 as a prognostic biomarker in epithelial ovarian cancer(EOC). Methods: Bmi-1 expression was assessed in 82 EOC tissues and 10 control tissues using immunochemistry. Statistical analyses were performed to investigate the associations between Bmi-1 expression and clinicopathological characteristics as well as survival time. Results: Positive Bmi-1 expression was detected in 87.8%(72/82) of EOC tissues and significantly higher expression of Bmi-1 was observed in EOC than in benign ovarian tumor tissues(P < 0.01).Cox regression analyses revealed that higher Bmi-1 level was significantly associated with poorer overall survival in patients with EOC(mean overall survival, 45.4 vs. 69.3 months) than those with benign ovarian tumors. Moreover, high Bmi-1 expression was an independent predictor for prognosis(HR= 2.212, 95% CI = 1.091-4.482, P < 0.05) in EOC patients. This was further confirmed by survival analysis based on Bmi-1 levels from a large patient cohort(1582 cases) derived from The Cancer Genome Atlas(TCGA) and Gene Expression Omnibus(GEO). Conclusions: High Bmi-1 expression is positively associated with metastastic disease and poor prognosis in EOC.
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