Immunotolerant HLA-G in tumor metastasis
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- 英文论文题名：Immunotolerant HLA-G in tumor metastasis
- 论文作者：Yan Wei-Hua
- 英文论文作者：Yan Wei-Hua ; Taizhou Hospital of Zhejiang Province
- 年：2016
- 作者机构：Taizhou Hospital of Zhejiang Province;
- 英文论文关键词：HLA-G ; cancer ; immune escape ; metastasis ; therapy target
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会摘要汇编
- 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R730.3
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：1262k
- 原文格式：D
- 会议级别：全国
摘要
Human leukocyte antigen G(HLA-G), a non-classic major histocompatibility complex(MHC) class I molecule, functions as a potent immune inhibitory molecule. The immune suppressive features of HLA-G include inhibition of immune cell cytotoxicity, differentiation, proliferation and alteration of the profile of cytokine secretion; induction of immune cell apoptosis; generation of regulatory cells and expansion of myeloid derived suppressive cells, and by impairment of chemotaxis. In the context of malignancies, aberrant induction of HLA-G expression has been observed in various tumor cells, in addition to above mentioned immune inhibitory function mediated by HLA-G, HLA-G could also arm tumor cells with higher migration, invasive and metastatic potential with the up-regulation of tumor-promoting factor expression such as the matrix metalloproteinases. In clinical settings, tumor HLA-G expression was found strongly associated with advanced disease stage and related to the poor prognosis for cancer patients. These findings indicated ectopic HLAG expression in tumors could render multiple effects during the progression of malignancies. In this review, we will briefly present an overview of what the mechanisms and significance of HLA-G involved in promoting tumor cell immune escaping, metastasis and disease progression, and what measures can be taken to counteract cancer development by targeting HLA-G.
Human leukocyte antigen G(HLA-G), a non-classic major histocompatibility complex(MHC) class I molecule, functions as a potent immune inhibitory molecule. The immune suppressive features of HLA-G include inhibition of immune cell cytotoxicity, differentiation, proliferation and alteration of the profile of cytokine secretion; induction of immune cell apoptosis; generation of regulatory cells and expansion of myeloid derived suppressive cells, and by impairment of chemotaxis. In the context of malignancies, aberrant induction of HLA-G expression has been observed in various tumor cells, in addition to above mentioned immune inhibitory function mediated by HLA-G, HLA-G could also arm tumor cells with higher migration, invasive and metastatic potential with the up-regulation of tumor-promoting factor expression such as the matrix metalloproteinases. In clinical settings, tumor HLA-G expression was found strongly associated with advanced disease stage and related to the poor prognosis for cancer patients. These findings indicated ectopic HLAG expression in tumors could render multiple effects during the progression of malignancies. In this review, we will briefly present an overview of what the mechanisms and significance of HLA-G involved in promoting tumor cell immune escaping, metastasis and disease progression, and what measures can be taken to counteract cancer development by targeting HLA-G.
Human leukocyte antigen G(HLA-G), a non-classic major histocompatibility complex(MHC) class I molecule, functions as a potent immune inhibitory molecule. The immune suppressive features of HLA-G include inhibition of immune cell cytotoxicity, differentiation, proliferation and alteration of the profile of cytokine secretion; induction of immune cell apoptosis; generation of regulatory cells and expansion of myeloid derived suppressive cells, and by impairment of chemotaxis. In the context of malignancies, aberrant induction of HLA-G expression has been observed in various tumor cells, in addition to above mentioned immune inhibitory function mediated by HLA-G, HLA-G could also arm tumor cells with higher migration, invasive and metastatic potential with the up-regulation of tumor-promoting factor expression such as the matrix metalloproteinases. In clinical settings, tumor HLA-G expression was found strongly associated with advanced disease stage and related to the poor prognosis for cancer patients. These findings indicated ectopic HLAG expression in tumors could render multiple effects during the progression of malignancies. In this review, we will briefly present an overview of what the mechanisms and significance of HLA-G involved in promoting tumor cell immune escaping, metastasis and disease progression, and what measures can be taken to counteract cancer development by targeting HLA-G.
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