A review of the pharmacological mechanism of Pseudolaric acid B and its derivatives
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- 英文论文题名：A review of the pharmacological mechanism of Pseudolaric acid B and its derivatives
- 论文作者：Liu Mei-Lun ; Li Tan ; Chen Hong
- 英文论文作者：Liu Mei-Lun ; Li Tan ; Chen Hong ; Department of Pharmacognosy and Pharmaceutics ; Logistics University of the Chinese People's Armed Police Force ; Department of Pathogen Biology and Immunology ; Logistics University of the Chinese People's Armed Police Force
- 年：2016
- 作者机构：Department of Pharmacognosy and Pharmaceutics,Logistics University of the Chinese People's Armed Police Force;Department of Pathogen Biology and Immunology,Logistics University of the Chinese People's Armed Police Force;
- 英文论文关键词：Pseudolaric acid B ; Immunopharmacology ; Tumor ; Inflammation
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会摘要汇编
- 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R285
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：2
- 文件大小：1355k
- 原文格式：D
- 会议级别：全国
摘要
Considering that extensive immunosuppressive agents have adverse reaction on normal cells to restrain their clinical application, researchers are devoting to find some novel agents with less side-effects and more security from Traditional Chinese Medicine(TCM). Cortex pseudolaricis, a kind of traditional Chinese medicine, has been used to treat tinea or other skin diseases since long time ago. Pseudolaric acid B(PAB) is the main effective diterpenoid of Cortex pseudolaricis. According to previous studies, PAB has been proved to markedly inhibit the growth and proliferation of many tumor cell lines by inducing mitotic catastrophe and apoptosis, and affect cell cycle, which makes it as a novel microtubule inhibitor. Moreover, it has been reported to exert favorable anti-inflammatory and immunosuppressive activities with less cytotoxicity.Through analyzing the correlational studies in recent decades, we have made a review on PAB and its derivatives, espe-cially the research development of its pharmacological activities.Even though the experimental utility of PAB is prevailing accepted, the mechanism is not completely clear so that we have a long way to explore the potential mechanisms of PAB against tumor and immune-related diseases.
Considering that extensive immunosuppressive agents have adverse reaction on normal cells to restrain their clinical application, researchers are devoting to find some novel agents with less side-effects and more security from Traditional Chinese Medicine(TCM). Cortex pseudolaricis, a kind of traditional Chinese medicine, has been used to treat tinea or other skin diseases since long time ago. Pseudolaric acid B(PAB) is the main effective diterpenoid of Cortex pseudolaricis. According to previous studies, PAB has been proved to markedly inhibit the growth and proliferation of many tumor cell lines by inducing mitotic catastrophe and apoptosis, and affect cell cycle, which makes it as a novel microtubule inhibitor. Moreover, it has been reported to exert favorable anti-inflammatory and immunosuppressive activities with less cytotoxicity.Through analyzing the correlational studies in recent decades, we have made a review on PAB and its derivatives, espe-cially the research development of its pharmacological activities.Even though the experimental utility of PAB is prevailing accepted, the mechanism is not completely clear so that we have a long way to explore the potential mechanisms of PAB against tumor and immune-related diseases.
Considering that extensive immunosuppressive agents have adverse reaction on normal cells to restrain their clinical application, researchers are devoting to find some novel agents with less side-effects and more security from Traditional Chinese Medicine(TCM). Cortex pseudolaricis, a kind of traditional Chinese medicine, has been used to treat tinea or other skin diseases since long time ago. Pseudolaric acid B(PAB) is the main effective diterpenoid of Cortex pseudolaricis. According to previous studies, PAB has been proved to markedly inhibit the growth and proliferation of many tumor cell lines by inducing mitotic catastrophe and apoptosis, and affect cell cycle, which makes it as a novel microtubule inhibitor. Moreover, it has been reported to exert favorable anti-inflammatory and immunosuppressive activities with less cytotoxicity.Through analyzing the correlational studies in recent decades, we have made a review on PAB and its derivatives, espe-cially the research development of its pharmacological activities.Even though the experimental utility of PAB is prevailing accepted, the mechanism is not completely clear so that we have a long way to explore the potential mechanisms of PAB against tumor and immune-related diseases.
引文