鹿茸再生相关蛋白研究进展
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- 英文论文题名：Rearch Progress in Proteins related to Deer Antler Regeneration
- 论文作者：王权威 ; 董振 ; 王桂武 ; 杨福合 ; 刘慧 ; 李春义
- 英文论文作者：Wang Quanwei ; Dong Zhen ; Wang Guiwu ; Yang Fuhe ; Liu Hui ; Li Chunyi ; State Key Lab for Molecular Biology of Special Animals/Institute of Special Animal and Plant Sciences ; Chinese Academy of Agricultural Science
- 年：2016
- 作者机构：中国农业科学院特产研究所特种动物分子生物学国家重点实验室;
- 论文关键词：鹿茸再生相关蛋白 ; 血管生成 ; 软骨形成 ; 神经再生
- 英文论文关键词：Proteins related to deer antler regeneration ; Angiogenesis ; Cartilage formation ; Nerve regeneration
- 会议召开时间：2016-06-01
- 会议录名称：“十二五” 鹿科学研究进展
- 语种：中文
- 分类号：S825
- 学会代码：ZXMY
- 学会名称：中国畜牧业协会
- 页数：8
- 文件大小：437k
- 原文格式：O
摘要
鹿茸是迄今为止发现的唯一能够周期性再生的哺乳动物器官,它的生长速度极快却没有发生癌变。而蛋白质是生命活动的体现者,是生命活动的功能执行者,鹿茸相关蛋的研究是揭开鹿茸再生秘密的重要途径。综述了鹿茸再生相关蛋白的筛选、血管生成相关蛋白、软骨形成相关蛋白、神经再生相关蛋白以及其他与鹿茸再生相关蛋白的研究进展,旨在为从蛋白质水平上揭示鹿茸再生过程提供基础资料。
Deer antlers are the only known mammalian organs that can periodically regenerate,and can grow most rapidly but without going cancerous.Proteins are the carrier of life activities and the functionexecutor of life activities,the research of proteins related to deer regeneration is an important way to unlock the secrets of the antlers regeneration.The proteins that are involved in angiogenesis,cartilage formation,nerve regeneration and other functions during antler regeneration were reviewed,aims at providing basic data for revealing antler regeneration process at the protein level.
Deer antlers are the only known mammalian organs that can periodically regenerate,and can grow most rapidly but without going cancerous.Proteins are the carrier of life activities and the functionexecutor of life activities,the research of proteins related to deer regeneration is an important way to unlock the secrets of the antlers regeneration.The proteins that are involved in angiogenesis,cartilage formation,nerve regeneration and other functions during antler regeneration were reviewed,aims at providing basic data for revealing antler regeneration process at the protein level.
引文
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[2]Li C,Suttie JM.Deer antlerogenic periosteum;a piece of postnatally retained embryonic tissue?[J].Anat Embryol(Berl).2001,204(5):375-388.
[3]Li C,Mackintosh CG,Martin SK,et al.Identification of key tissue type for antler regeneration through pedicle periosteum deletion[J].Cell Tissue Res,2007,328:65-75.
[4]Li C.Development of deer antler model for biomedical research[J].Recent Adv Res Updates,2003,4:256-274.
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[7]Maki N,Takechi K,Sano S,et al.Rapid accumulation of nucleostemin in nucleolus during newt regeneration[J].Dev Dyn.2007,236(4):941-950.
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[15]Li C,Suttie J M,Clark D E.Morphological observation of antler regeneration in red deer(Cervuselaphus)[J].J Morphol.2004,262(3):731-740.
[16]Park HJ,Lee DH,Park SG,et al.Proteome analysis of red deer antlers[J].Proteomics,2004,4(11):3642-3653.
[17]Farberov S,Meidan R.Functions and transcriptional regulation of thrombospondins and their interrelationship with fibroblast growth factor-2 in bovine luteal cells[J].Biol Reprod,2014,91(3):58.
[18]Lai AK,Hou WL,Verdon DJ,et al.The distribution of the growth factors FGF-2 and VEGF,and their receptors,in growing red deer antler[J].Tissue and Cell,2007,39(1):35-46.
[19]Maa HC,Chao TT,Wang CY,et al.VEGF-D as a Marker in the Aid of Malignant Metastatic Pleural Effusion Diagnosis[J].Appl Immunohistochem Mol Morphol.2014 Sep 15.in press,doi;10.1097/PAI.0000000000000079.
[20]Istvanffy R,Kr ger M,Eckl C,et al.Stromal pleiotrophin regulates repopulation behavior of hematopoietic stem cells[J].Blood.2011,118(10):2 712-2 722.
[21]Besse S,Comte R,Frechault S,et al.Pleiotrophin promotes capillary-like sprouting from senescent aortic rings[J].Cytokine.2013,62(1):44-47.
[22]Clark DE,Lord E A,Suttie JM.Expression of VEGF and pleiotrophin in deer antler[J].Anat Rec,2006,288A:1 281-1 293.
[23]Li R,Beebe T,Jen N,et al.Shear stress-activated wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos[J].Arterioscler Thromb Vase Biol.2014,34(10):2 268-2 275.
[24]Sinnathamby T,Yun TJ,Clavet-Lanthier ME,et al.VEGF and angiopoietins promote inflammatory cell recruitment and mature blood vessel formation in murine sponge/Matrigel model[J]-J Cell Biochem.2014,in press,doi:10.1002/jcb.24941.
[25]Kronenberg HM.Developmental regulation of the growth plate[J].Nature,2003,423:332-336.
[26]Scheel C,Eaton EN,Li SH.Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast[J].Cell.2011,145(6):926-940.
[27]Jortikka L,Marttinen A,Lindholm TS.Partially purified reindeer(Rangifer tarandus)bone morphogenetic protein has a high bone-forming activity compared with some other artiodactyls[J].Clin Orthop Relat Res.1993,207:31-35.
[28]Pekkarinen T,J ms T,M tt M,et al.Reindeer BMP extract in the healing of critical-size bone defects in the radius of the rabbit[J].Acta Orthop.2006,77(6):952-959.
[29]郝林琳,刘松财,张明军,等.鲜马鹿茸不同部位多肽的提取及含量比较[J].吉林农业大学学报,2007,29(4):378-380,383.
[30]Garcial RL.Expression of NT-3 in the growing valver antler of the red deer cervus elaphus[J].JMol Endocrinol,1997,19(2):173-182.
[31]Li C,Stanton J A,Robertson TM,et al.Nerve growth factor mRNA expression in the regenerating antler tip of red deer(Cervus elaphus)[J].PLoS ONE,2007,2(1):el48-155.
[32]Garcia-Gutierrez P,Juarez-Vicente F,Wolgemuth DJ,et al.Pleiotrophin antagonizes Brd2during neuronal differentiation[J].J Cell Sci.2014,127(11):2 554-2 564.
[33]Harper A,Li C.Identifying ligands for S100A4 and galectin-1 in antler stem cells.Queenstown Molecular Biology Meetings:Q35[C].New Zealand:The Queenstown Molecular Biology Meeting Society Inc,2009.
[34]Boudignon BM,Bikle DD,Kurimoto P,et al.Insulin-like growth factor 1 stimulates recovery of bone lost after a period of skeletal unloading[J].J Appl Physiol,2007,103(1):125-131.
[35]Sadighi M.Effect of insulin-like growth factor-I(IGF-I)and IGF-II on the growth of antler cells in vitro[J].J Endocrinal,1994,143(3):461-469.
[36]Lord EA,Martin SK,Gray JP,et al.Cell Cycle Genes PEDF and CDKNIC in Growing Deer Antlers[J].The Anatomical Record.2007,290:994-1 004.
[37]Hong H,Zhou T,Fang S,et al.Pigment epithelium-derived factor(PEDF)inhibits breast cancer metastasis by down-regulating fibronectin[J].Breast Cancer Res Treat.2014,148(1):61-72.
[2]Li C,Suttie JM.Deer antlerogenic periosteum;a piece of postnatally retained embryonic tissue?[J].Anat Embryol(Berl).2001,204(5):375-388.
[3]Li C,Mackintosh CG,Martin SK,et al.Identification of key tissue type for antler regeneration through pedicle periosteum deletion[J].Cell Tissue Res,2007,328:65-75.
[4]Li C.Development of deer antler model for biomedical research[J].Recent Adv Res Updates,2003,4:256-274.
[5]Rolf HJ,Kierdorf U,Kierdorf H,et al.Localization and characterization of stro-1 cells in the deer pedicle and regenerating antler[J].PLoS One.2008,3(4):e2064.
[6]Beekman C,Nichane M,De Clercq S,et al.Evolutionarily conserved role of nucleostemin;controlling proliferation of stem/progenitor cells during early vertebrate development[J].Mol Cell Biol.2006,26(24):9291-9301.
[7]Maki N,Takechi K,Sano S,et al.Rapid accumulation of nucleostemin in nucleolus during newt regeneration[J].Dev Dyn.2007,236(4):941-950.
[8]Berg DK,Li C,Asher G,et al.Red deer cloned from antler stem cells and their differentiated progeny[J].Biol Reprod.2007,77(3):384-394.
[9]Li C,Suttie JM.Tissue collection methods for antler research[J].Eur J Morphol.2003,41(1):23-30.
[10]Li C,Harper A,Puddick J,et al.Proteomes and signalling pathways of antler stem cells[J].PLoS One,2012,7(1):e30026.
[11]徐代勋.梅花鹿鹿茸角柄骨膜不同部位差异蛋白的筛选[D].镇江:江苏科技大学.2011.
[12]徐代勋,王桂武,赵海平,等.梅花鹿角柄骨膜蛋白质组学初步研究[J].特产研究,2011,33(1):1-4.
[13]赵东.梅花鹿鹿茸双向电泳体系建立及蛋白质组学的研究[D].镇江:江苏科技大学.2012.
[14]Gao L,Tao D,Shan Y,et al.HPLC-MS/MS shotgun proteomic research of deer antlers with multiparallel protein extraction methods[J].Journal of Chromatography B,2010,878(32):3 370-3 374.
[15]Li C,Suttie J M,Clark D E.Morphological observation of antler regeneration in red deer(Cervuselaphus)[J].J Morphol.2004,262(3):731-740.
[16]Park HJ,Lee DH,Park SG,et al.Proteome analysis of red deer antlers[J].Proteomics,2004,4(11):3642-3653.
[17]Farberov S,Meidan R.Functions and transcriptional regulation of thrombospondins and their interrelationship with fibroblast growth factor-2 in bovine luteal cells[J].Biol Reprod,2014,91(3):58.
[18]Lai AK,Hou WL,Verdon DJ,et al.The distribution of the growth factors FGF-2 and VEGF,and their receptors,in growing red deer antler[J].Tissue and Cell,2007,39(1):35-46.
[19]Maa HC,Chao TT,Wang CY,et al.VEGF-D as a Marker in the Aid of Malignant Metastatic Pleural Effusion Diagnosis[J].Appl Immunohistochem Mol Morphol.2014 Sep 15.in press,doi;10.1097/PAI.0000000000000079.
[20]Istvanffy R,Kr ger M,Eckl C,et al.Stromal pleiotrophin regulates repopulation behavior of hematopoietic stem cells[J].Blood.2011,118(10):2 712-2 722.
[21]Besse S,Comte R,Frechault S,et al.Pleiotrophin promotes capillary-like sprouting from senescent aortic rings[J].Cytokine.2013,62(1):44-47.
[22]Clark DE,Lord E A,Suttie JM.Expression of VEGF and pleiotrophin in deer antler[J].Anat Rec,2006,288A:1 281-1 293.
[23]Li R,Beebe T,Jen N,et al.Shear stress-activated wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos[J].Arterioscler Thromb Vase Biol.2014,34(10):2 268-2 275.
[24]Sinnathamby T,Yun TJ,Clavet-Lanthier ME,et al.VEGF and angiopoietins promote inflammatory cell recruitment and mature blood vessel formation in murine sponge/Matrigel model[J]-J Cell Biochem.2014,in press,doi:10.1002/jcb.24941.
[25]Kronenberg HM.Developmental regulation of the growth plate[J].Nature,2003,423:332-336.
[26]Scheel C,Eaton EN,Li SH.Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast[J].Cell.2011,145(6):926-940.
[27]Jortikka L,Marttinen A,Lindholm TS.Partially purified reindeer(Rangifer tarandus)bone morphogenetic protein has a high bone-forming activity compared with some other artiodactyls[J].Clin Orthop Relat Res.1993,207:31-35.
[28]Pekkarinen T,J ms T,M tt M,et al.Reindeer BMP extract in the healing of critical-size bone defects in the radius of the rabbit[J].Acta Orthop.2006,77(6):952-959.
[29]郝林琳,刘松财,张明军,等.鲜马鹿茸不同部位多肽的提取及含量比较[J].吉林农业大学学报,2007,29(4):378-380,383.
[30]Garcial RL.Expression of NT-3 in the growing valver antler of the red deer cervus elaphus[J].JMol Endocrinol,1997,19(2):173-182.
[31]Li C,Stanton J A,Robertson TM,et al.Nerve growth factor mRNA expression in the regenerating antler tip of red deer(Cervus elaphus)[J].PLoS ONE,2007,2(1):el48-155.
[32]Garcia-Gutierrez P,Juarez-Vicente F,Wolgemuth DJ,et al.Pleiotrophin antagonizes Brd2during neuronal differentiation[J].J Cell Sci.2014,127(11):2 554-2 564.
[33]Harper A,Li C.Identifying ligands for S100A4 and galectin-1 in antler stem cells.Queenstown Molecular Biology Meetings:Q35[C].New Zealand:The Queenstown Molecular Biology Meeting Society Inc,2009.
[34]Boudignon BM,Bikle DD,Kurimoto P,et al.Insulin-like growth factor 1 stimulates recovery of bone lost after a period of skeletal unloading[J].J Appl Physiol,2007,103(1):125-131.
[35]Sadighi M.Effect of insulin-like growth factor-I(IGF-I)and IGF-II on the growth of antler cells in vitro[J].J Endocrinal,1994,143(3):461-469.
[36]Lord EA,Martin SK,Gray JP,et al.Cell Cycle Genes PEDF and CDKNIC in Growing Deer Antlers[J].The Anatomical Record.2007,290:994-1 004.
[37]Hong H,Zhou T,Fang S,et al.Pigment epithelium-derived factor(PEDF)inhibits breast cancer metastasis by down-regulating fibronectin[J].Breast Cancer Res Treat.2014,148(1):61-72.