Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
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- 英文论文题名：Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
- 论文作者：Cong Chen ; Peili Gu ; Jian Wu ; Xianyun Chen ; Shuangshuang Niu ; Lijie Wu ; Na Li ; Junhui Peng ; Cuiying Fan ; Min Huang ; Catherine C.L.Wong ; Qingguo Gong ; Rongguang Zhang ; Lajos Pusztai ; Sandy Chang ; Ming Lei
- 英文论文作者：Cong Chen ; Peili Gu ; Jian Wu ; Xianyun Chen ; Shuangshuang Niu ; Lijie Wu ; Na Li ; Junhui Peng ; Cuiying Fan ; Min Huang ; Catherine C.L.Wong ; Qingguo Gong ; Rongguang Zhang ; Lajos Pusztai ; Sandy Chang ; Ming Lei ; National Center for Protein Science Shanghai ; State Key Laboratory of Molecular Biology ; Institute of Biochemistry and Cell Biology ; Shanghai Institutes for Biological Sciences ; Chinese Academy of Sciences ; Shanghai Research Center ; Chinese Academy of Sciences ; Department of Pathology and 5Department of Medicine ; Yale School of Medicine ; National Laboratory for Physical Science at the Microscale and School of Life Sciences ; University of Science and Technology of China
- 年：2016
- 作者机构：National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;Shanghai Research Center, Chinese Academy of Sciences;Department of Pathology and 5Department of Medicine, Yale School of Medicine;National Laboratory for Physical Science at the Microscale and School of Life Sciences, University of Science and Technology of China;
- 英文论文关键词：Telomere ; POT1 ; TPP1 ; Crystal structure ; Human cancer
- 会议召开时间：2016-10-20
- 会议录名称：中国生物化学与分子生物学会2016年全国学术会议论文集
- 语种：英文
- 分类号：R730.2
- 学会代码：IGSS
- 会议名称：中国生物化学与分子生物学会2016年全国学术会议
- 会议地点：中国浙江杭州
- 主办单位：中国生物化学与分子生物学会
- 学会名称：中国生物化学与分子生物学会
- 页数：2
- 文件大小：6865k
- 原文格式：D
- 会议级别：全国
摘要
<正>Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects chromosome ends and regulates telomerase-mediated telomere extension.However,how POT1 interacts with TPP1 to form a heterodimer remains unknown.Here we present the crystal structure of the C-terminal portion of human POT1(POT1C)complexed with the POT1-binding-
引文