多孔石墨烯纳米纤维的静电纺丝法制备及其载药性能研究
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- 英文论文题名：Fabrication of Porous Graphene Nanofibers via Electrospinning and its Performance for Drug Delivery
- 论文作者：张苒 ; 郭守武
- 英文论文作者：Ran zhang ; Shouwu Guo ; College of electronic information and electrical engineering ; Shanghai jiaotong university
- 年：2016
- 作者机构：上海交通大学;上海交通大学电子信息与电气工程学院;
- 论文关键词：静电纺丝 ; 氧化石墨烯 ; 纳米纤维 ; 二氧化硅
- 会议召开时间：2016-11-18
- 会议录名称：中国第四届静电纺丝大会（CICE 2016）摘要集
- 语种：中文
- 分类号：TQ460.1;TQ340.64
- 学会代码：ZGNM
- 会议名称：中国第四届静电纺丝大会(CICE 2016)
- 会议地点：中国北京
- 主办单位：中国复合材料学会超细纤维材料分会（筹）
- 学会名称：中关村科创纳米技术创新研究会
- 页数：1
- 文件大小：988k
- 原文格式：D
- 会议级别：全国
摘要
静电纺丝能够高效制备形貌均一且具有多级孔隙结构和高比表面积的一维纳米纤维,在催化转化和生物吸附等领域有着广泛的应用。氧化石墨烯具有多种含氧官能团,易于与其他材料复合。本文首先采用溶胶-凝胶法,将二氧化硅微球、氧化石墨烯和聚丙烯腈按照10:1:20及20:1:20的质量比溶于N,N-二甲基甲酰胺(DMF)溶剂中,结合静电纺丝和高温煅烧的方法制备出多孔石墨烯复合纳米纤维,并利用SEM、TEM、FTIR与XPS等表征方法,证明得到了具有2~50nm介孔结构的多孔复合纳米纤维;然后采用浸渍法对多孔纳米纤维负载药物,并在模拟胃肠液中进行药物释放,采用紫外分光光度计测定药物的累积释放浓度,证明吸附的药物分子在模拟肠液中的释放率均高于模拟胃液,最大的释放率可达到81.3%,最大药物吸附量可达到225mg/g,并且制备的多孔石墨烯纳米纤维具有一定的缓释效果,有望应用于生物医药等领域。
In this work,we fabricated Graphene Oxide composite nanofiber via electrospinning through dissolved SiO_2nanospheres,Graphene Oxide and PAN in DMF as the weight ratio of 10:1:20 and 20:1:20,respectively.After a series of preoxidation and carboninantion process,the porous nanofiber was prepared and loaded with drugs.Then the adsorbent nanofiber was released in SBF and SIF to investigate its adsorption performance by using a UV-vis spectrophotometer at 274 nm based on an appropriate calibration curve.The results demonstrated the largest drug adsorption capacity could reach 225 mg/g and the naofiber presented good sustained-release effect.
In this work,we fabricated Graphene Oxide composite nanofiber via electrospinning through dissolved SiO_2nanospheres,Graphene Oxide and PAN in DMF as the weight ratio of 10:1:20 and 20:1:20,respectively.After a series of preoxidation and carboninantion process,the porous nanofiber was prepared and loaded with drugs.Then the adsorbent nanofiber was released in SBF and SIF to investigate its adsorption performance by using a UV-vis spectrophotometer at 274 nm based on an appropriate calibration curve.The results demonstrated the largest drug adsorption capacity could reach 225 mg/g and the naofiber presented good sustained-release effect.
引文
[1]Martin K,Dufficy;Saad A.Khan;et al.ACS Appl.Mater.Interfaces 2016,8,1327.
[2]Zhao R,Wang Y,Li X,et al.ACS Sustainable Chem.Eng.2016,4,2584.
[3]Jung-Hye Eom,Young-Wook Kim,Santosh Raju.Journal of Asian Ceramic Societies.2013,1,220.
[2]Zhao R,Wang Y,Li X,et al.ACS Sustainable Chem.Eng.2016,4,2584.
[3]Jung-Hye Eom,Young-Wook Kim,Santosh Raju.Journal of Asian Ceramic Societies.2013,1,220.