Chromatography/Mass Spectrometry-Based Biomarkers in the Field of Obstructive Sleep Apnea
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- 英文论文题名：Chromatography/Mass Spectrometry-Based Biomarkers in the Field of Obstructive Sleep Apnea
- 论文作者：Huajun Xu ; Xiaojiao Zheng ; Shankai Yin
- 英文论文作者：Huajun Xu ; Xiaojiao Zheng ; Shankai Yin ; Department of Otolaryngology ; Shanghai Jiao Tong University Affiliated Sixth People's Hospital ; Otolaryngology Institute of Shanghai Jiao Tong University
- 年：2016
- 作者机构：Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University;
- 会议召开时间：2016-05-27
- 会议录名称：中国睡眠研究会第九届学术年会汇编
- 语种：英文
- 分类号：R766
- 学会代码：OGSF
- 会议名称：中国睡眠研究会第九届学术年会
- 会议地点：中国上海
- 主办单位：中国睡眠研究会
- 学会名称：中国睡眠研究会
- 页数：1
- 文件大小：32k
- 原文格式：O
- 会议级别：全国
摘要
Biomarker assessment is based on quantifying several proteins and metabolites.Recent developments in proteomics and metabolomics have enabled detection of these small molecules in biological samples and exploration of the underlying disease mechan- isms in obstructive sleep apnea(OSA).This systemic review was performed to identify biomarkers,which were only detected by chroma- tography and/or mass spectrometry(MS) and to discuss the role of these biomarkers in the field of OSA.We systemically reviewed relevant articles from PubMed and EMBASE referring to proteins and metabolite profiles of biological samples in patients with OSA.The analytical platforms in this review were focused on chromatography and/or MS.In total,30 studies evaluating biomarkers in patients with OSA using chromatography and/or MS methods were included.Numerous proteins and metabolites,including lipid profiles,adrenergic/dopaminergic bio- markers and derivatives,amino acids,oxidative stress biomarkers,and other micromolecules were identified in patients with OSA.Applying chromatography and/or MS methods to detect biomarkers helps develop an understanding of OSA mechanisms.More proteomic and metabolomic studies are warranted to develop potential diagnostic and clinical monitoring methods for OSA.
Biomarker assessment is based on quantifying several proteins and metabolites.Recent developments in proteomics and metabolomics have enabled detection of these small molecules in biological samples and exploration of the underlying disease mechan- isms in obstructive sleep apnea(OSA).This systemic review was performed to identify biomarkers,which were only detected by chroma- tography and/or mass spectrometry(MS) and to discuss the role of these biomarkers in the field of OSA.We systemically reviewed relevant articles from PubMed and EMBASE referring to proteins and metabolite profiles of biological samples in patients with OSA.The analytical platforms in this review were focused on chromatography and/or MS.In total,30 studies evaluating biomarkers in patients with OSA using chromatography and/or MS methods were included.Numerous proteins and metabolites,including lipid profiles,adrenergic/dopaminergic bio- markers and derivatives,amino acids,oxidative stress biomarkers,and other micromolecules were identified in patients with OSA.Applying chromatography and/or MS methods to detect biomarkers helps develop an understanding of OSA mechanisms.More proteomic and metabolomic studies are warranted to develop potential diagnostic and clinical monitoring methods for OSA.
Biomarker assessment is based on quantifying several proteins and metabolites.Recent developments in proteomics and metabolomics have enabled detection of these small molecules in biological samples and exploration of the underlying disease mechan- isms in obstructive sleep apnea(OSA).This systemic review was performed to identify biomarkers,which were only detected by chroma- tography and/or mass spectrometry(MS) and to discuss the role of these biomarkers in the field of OSA.We systemically reviewed relevant articles from PubMed and EMBASE referring to proteins and metabolite profiles of biological samples in patients with OSA.The analytical platforms in this review were focused on chromatography and/or MS.In total,30 studies evaluating biomarkers in patients with OSA using chromatography and/or MS methods were included.Numerous proteins and metabolites,including lipid profiles,adrenergic/dopaminergic bio- markers and derivatives,amino acids,oxidative stress biomarkers,and other micromolecules were identified in patients with OSA.Applying chromatography and/or MS methods to detect biomarkers helps develop an understanding of OSA mechanisms.More proteomic and metabolomic studies are warranted to develop potential diagnostic and clinical monitoring methods for OSA.
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