Dynamic effect of three amphiphilic transdermal penetration enhancers on membrane structure
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- 英文论文题名：Dynamic effect of three amphiphilic transdermal penetration enhancers on membrane structure
- 论文作者：Shanshan Li ; Yongshan Zhao
- 英文论文作者：Shanshan Li ; Yongshan Zhao ; School of Life Science and Bio-Pharmaceutics ; Shenyang Pharmaceutical University
- 年：2016
- 作者机构：School of Life Science and Bio-Pharmaceutics,Shenyang Pharmaceutical University;
- 英文论文关键词：molecular dynamic ; membrane
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第十九分会：化学中的量子与经典动力学
- 语种：英文
- 分类号：R284
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第十九分会 ; 化学中的量子与经典动力学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：171k
- 原文格式：D
- 会议级别：全国
摘要
In this study, three amphiphilic percutaneous absorption enhancers,namely isopulegol decanoate(ISO-10), menthol decanoate(MT-10), Azone(AZ), were selected to clarify enhancing kinetics which meant changes in promoting effect of enhancers as the application time prolonged. All molecular dynamics(MD) simulations were performed using GROMACS version 5.0 and all the molecular images were generated using VMD software. In this study, ISO-10, MT-10 and AZ showed significant enhancing effects and the enhancers showed dynamic enhancing activity against time.While,after the addition of enhancers, well-organized membrane showed more disordered arrangement(Fig1). In conclusion, The diffusion coefficients suggested fluidity of lipids with the disturbance of enhancers.~([1]) The whole run time was divided into 20 periods, and the slope of each curve was obtained from Fig2. It is evident that the stability of the bilayer was disturbed caused by the enhancers' interruption in all systems~([2])( Fig3).
In this study, three amphiphilic percutaneous absorption enhancers,namely isopulegol decanoate(ISO-10), menthol decanoate(MT-10), Azone(AZ), were selected to clarify enhancing kinetics which meant changes in promoting effect of enhancers as the application time prolonged. All molecular dynamics(MD) simulations were performed using GROMACS version 5.0 and all the molecular images were generated using VMD software. In this study, ISO-10, MT-10 and AZ showed significant enhancing effects and the enhancers showed dynamic enhancing activity against time.While,after the addition of enhancers, well-organized membrane showed more disordered arrangement(Fig1). In conclusion, The diffusion coefficients suggested fluidity of lipids with the disturbance of enhancers.~([1]) The whole run time was divided into 20 periods, and the slope of each curve was obtained from Fig2. It is evident that the stability of the bilayer was disturbed caused by the enhancers' interruption in all systems~([2])( Fig3).
In this study, three amphiphilic percutaneous absorption enhancers,namely isopulegol decanoate(ISO-10), menthol decanoate(MT-10), Azone(AZ), were selected to clarify enhancing kinetics which meant changes in promoting effect of enhancers as the application time prolonged. All molecular dynamics(MD) simulations were performed using GROMACS version 5.0 and all the molecular images were generated using VMD software. In this study, ISO-10, MT-10 and AZ showed significant enhancing effects and the enhancers showed dynamic enhancing activity against time.While,after the addition of enhancers, well-organized membrane showed more disordered arrangement(Fig1). In conclusion, The diffusion coefficients suggested fluidity of lipids with the disturbance of enhancers.~([1]) The whole run time was divided into 20 periods, and the slope of each curve was obtained from Fig2. It is evident that the stability of the bilayer was disturbed caused by the enhancers' interruption in all systems~([2])( Fig3).
引文
[1]Mojumdar,E.H.;Lyubartsev,A.P.,Molecular dynamics simulations of local anesthetic articaine in a lipid bilayer.Biophysical Chemistry 2010,153(1),27-35.
[2]Abbas Yousefpour,Sepideh Amjad Iranagh,Yousef Nademi,Hamid Modarress,Molecular dynamics simulation of nonsteroidal antiinflammatory drugs,naproxen and relafen,in a lipid bilayer membrane,Int.J.Quantum Chem.2013,113(15),1919-1930.
[2]Abbas Yousefpour,Sepideh Amjad Iranagh,Yousef Nademi,Hamid Modarress,Molecular dynamics simulation of nonsteroidal antiinflammatory drugs,naproxen and relafen,in a lipid bilayer membrane,Int.J.Quantum Chem.2013,113(15),1919-1930.