The study of serum level of M1 macrophage in Echinococcosis
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- 英文论文题名：The study of serum level of M1 macrophage in Echinococcosis
- 论文作者：PENG SHANSHAN ; WANG LIANG ; YANG WENQIANG ; SUN YANAN ; LI BIN ; JIANG TAO ; DING JIANBING ; WEN HAO ; MA XIUMIN
- 英文论文作者：PENG SHANSHAN ; WANG LIANG ; YANG WENQIANG ; SUN YANAN ; LI BIN ; JIANG TAO ; DING JIANBING ; WEN HAO ; MA XIUMIN ; State Key Laboratory Incubation Base of Xinjiang Major Diseases Research (2010DS890294) and Xinjiang Key Laboratory of Echinococcosis ; First Affiliated Hospital of Xinjiang Medical University ; College of Basic Medicine of Xinjiang Medical University
- 年：2016
- 作者机构：State Key Laboratory Incubation Base of Xinjiang Major Diseases Research (2010DS890294) and Xinjiang Key Laboratory of Echinococcosis,First Affiliated Hospital of Xinjiang Medical University;College of Basic Medicine of Xinjiang Medical University;
- 英文论文关键词：macrophage ; M1 ; Echinococcosis
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会壁报交流集
- 英文会议录名称：Proceedings of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R532.32
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：973k
- 原文格式：D
- 会议级别：全国
摘要
Objective:Echinococcosis is a zoonotic parasitic disease of human and mammalians caused mainly by the larval stages of Echinococcus.In the process of defense,macrophages polarize gradually into two different subtypes.It suggested that there is a close bond between macrophages polarization and the outcomes of different diseases.Characterized by expressing CD16/32+、CD68+、CD86+、MHC Ⅱ,M1 had a strong ability of inducing an anti-inflammatory effect on immune system to maintain homeostasis.Through high expression of IL–6,low expression of IL–10 and TGF-β1 to eliminate pathogen.Method:Therefore,in this research,we tracked the M1 relative cytokine of infected mice in different period through RT-PCR,immuhistochemistry and CBA.Result:The RT-PCR and CBA have found that M1 and the relative cytokine increased in the early stage and decreased in late.The immuhistochemistry show the same phenomenon.Conclusion:Macrophages as a nonspecific immune response cells and the antigen presenting cell of specific immune response play an important role to preserve host integrity in the development of hydatid diseases.After the polarization,M1 appeared in the early period,which probably is a way to protect host from pathogen.
Objective:Echinococcosis is a zoonotic parasitic disease of human and mammalians caused mainly by the larval stages of Echinococcus.In the process of defense,macrophages polarize gradually into two different subtypes.It suggested that there is a close bond between macrophages polarization and the outcomes of different diseases.Characterized by expressing CD16/32+、CD68+、CD86+、MHC Ⅱ,M1 had a strong ability of inducing an anti-inflammatory effect on immune system to maintain homeostasis.Through high expression of IL–6,low expression of IL–10 and TGF-β1 to eliminate pathogen.Method:Therefore,in this research,we tracked the M1 relative cytokine of infected mice in different period through RT-PCR,immuhistochemistry and CBA.Result:The RT-PCR and CBA have found that M1 and the relative cytokine increased in the early stage and decreased in late.The immuhistochemistry show the same phenomenon.Conclusion:Macrophages as a nonspecific immune response cells and the antigen presenting cell of specific immune response play an important role to preserve host integrity in the development of hydatid diseases.After the polarization,M1 appeared in the early period,which probably is a way to protect host from pathogen.
Objective:Echinococcosis is a zoonotic parasitic disease of human and mammalians caused mainly by the larval stages of Echinococcus.In the process of defense,macrophages polarize gradually into two different subtypes.It suggested that there is a close bond between macrophages polarization and the outcomes of different diseases.Characterized by expressing CD16/32+、CD68+、CD86+、MHC Ⅱ,M1 had a strong ability of inducing an anti-inflammatory effect on immune system to maintain homeostasis.Through high expression of IL–6,low expression of IL–10 and TGF-β1 to eliminate pathogen.Method:Therefore,in this research,we tracked the M1 relative cytokine of infected mice in different period through RT-PCR,immuhistochemistry and CBA.Result:The RT-PCR and CBA have found that M1 and the relative cytokine increased in the early stage and decreased in late.The immuhistochemistry show the same phenomenon.Conclusion:Macrophages as a nonspecific immune response cells and the antigen presenting cell of specific immune response play an important role to preserve host integrity in the development of hydatid diseases.After the polarization,M1 appeared in the early period,which probably is a way to protect host from pathogen.
引文