开关孔道介孔硅的制备及其在多肽提取中的应用
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- 英文论文题名：Highly anti-interference selective extraction of peptides by photo switching tunnel of mesoporous silica
- 论文作者：彭佳喜 ; 徐桂菊 ; 刘胜菊 ; 张红燕 ; 李鑫 ; 吴仁安
- 英文论文作者：Jiaxi Peng ; Guiju Xu ; Shengju Liu ; Hongyan Zhang ; Xin Li ; Ren'an Wu ; Dalian Institute of Chemical Physics Chinese Academy of Sciences ; University of Chinese Academy of Sciences
- 年：2016
- 作者机构：中科院大连化学物理研究所;中国科学院大学;
- 论文关键词：内源性多肽 ; 光响应 ; 介孔硅 ; 开关孔道
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十三分会：复杂样品分离分析
- 语种：中文
- 分类号：TQ127.2;TB383.4;TS252.4
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十三分会 ; 复杂样品分离分析
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：253k
- 原文格式：D
- 会议级别：全国
摘要
内源性多肽是生物体液中的重要组成部分。~([1])牛奶中的内源性多肽具有调节血压、促进消化和增强免疫等作用。~([2])然而内源性多肽在体液中的含量相对较低,且高丰度的蛋白、脂质和盐等物质会对其检测产生严重的干扰。针对以上挑战,我们制备了具有光响应开关孔道的新型介孔硅纳米材料,通过外部光刺激可人为操控孔道开关行为,选择性提取牛奶中的内源性多肽,为进一步研究其生理功能奠定了基础。
Endogenous peptides in body fluid play essential roles in regulating the basic physiological activities of the individual.Endogenous peptides in the milk may have a significant relationship with the cardiovascular,digestive and immune system.However,high abundant protein,lipids,and salts in these complex samples make the large scale analysis of endogenous peptides still challenging.Herein,we synthesize a kind of mesoporous silica with photo switching tunnel which can balance the retention of the target peptides and elimination of the interference in the complex biological fluids sample.
Endogenous peptides in body fluid play essential roles in regulating the basic physiological activities of the individual.Endogenous peptides in the milk may have a significant relationship with the cardiovascular,digestive and immune system.However,high abundant protein,lipids,and salts in these complex samples make the large scale analysis of endogenous peptides still challenging.Herein,we synthesize a kind of mesoporous silica with photo switching tunnel which can balance the retention of the target peptides and elimination of the interference in the complex biological fluids sample.
引文
[1]Mahboob,S.;Mohamedali,A.;Ahn,S.B.;Schulz-Knappe,P.;Nice,E.;Baker,M.S.Journal of Proteomics2015,127:300.
[2]Baum,F.;Fedorova,M.;Ebner,J.;Hoffmann,R.;Pischetsrieder,M.Journal of proteome research 2013,12:5447.
[2]Baum,F.;Fedorova,M.;Ebner,J.;Hoffmann,R.;Pischetsrieder,M.Journal of proteome research 2013,12:5447.