基于环糊精星形聚合物的制备及其对DOX药物控释性能研究
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- 英文论文题名：Studies on the preparation and characterization of DOX drug controlled release star-shaped copolymer based on β-cyclodextrin
- 论文作者：卢贝贝 ; 刘志勇
- 英文论文作者：Beibei Lu ; Zhiyong Liu ; College of Chemistry and Chemical Engineering ; University of Shihezi
- 年：2016
- 作者机构：石河子大学化学化工学院;
- 论文关键词：β-环糊精 ; 自组装 ; 星形共聚物 ; 药物传递 ; 控制释放
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十一分会：胶体与界面化学
- 语种：中文
- 分类号：O631;TQ460.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十一分会 ; 胶体与界面化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：410k
- 原文格式：D
- 会议级别：全国
摘要
刺激响应性药物传递系统作为一种新型的肿瘤靶向药物转运方式。近年来,双亲性纳米载药系统在药物运输和释放中受到广泛应用。本工作利用开环聚合(ROP)和原子转移自由基聚合(ATRP),合成了以β-环糊精-ε-己内酯(β-CD-PCL)为核,2-甲基-2-丙烯酸-2-(2-甲氧基乙氧基)乙酯)与寡聚乙二醇甲醚甲基丙烯酸酯P(MEO_2MA-co-PEGMA)共聚物为壳的温度敏感性星型聚合物。在自组装过程中,聚合物可以包载疏水性抗癌药物。这种药物载体进入体内循环后,通过增强渗透与滞留(EPR)效应将载体传递到肿瘤细胞,在到达肿瘤细胞的特殊环境下,温度敏感基团会发生断裂,导致胶束结构破坏,释放出包载的药物。细胞活性和激光共聚焦显微镜试验表明共聚物本身的低毒性,包载阿霉素(DOX)后的有效的细胞抑制作用及载体可以运载抗癌药物DOX并进行有效的控制释放。因此,两亲性共聚物胶束可作为潜在的药物和基因共同载体。
Stimuli-responsive drug delivery was a new type of tumor targeting drug delivery system.In recent years,the amphiphilic drug delivery system has been widely used in drug delivery and release.Well-defined amphiphilicβ-cyclodextrin(β-CD) star-shaped copolymers with poly(e-caprolactone)-poly(2-(2-methoxyethoxy)ethyl methacrylate)-co-Poly(ethylene glycol) methacrylate)(β-CD-(PCL-P(MEO_2MA-co-PEGMA))_(21) were synthesized via ring opening polymerization(ROP) and transfer radical polymerization(ATRP).The copolymer can be loaded hydrophobic anticancer drugs,with the process of self-assembly.The drug carrier composite nanoparticles into the loop body,carrier to the tumor cells by the EPR effect.In the special environment of the tumor cells,the thermo-sensitive groups will rupture,causing the micelle structure was destroyed and the entrapped drug of the release.Cell activity and CLSM experiment showed low toxicity of copolymers,the encapsulation of doxorubicin(DOX) after the effective cell inhibitory effect and the vector carrying anticancer drug doxorubicin and effective control of drug release.Therefore,the amphiphilic copolymer micelles could be used as potential drug and gene carrier.
Stimuli-responsive drug delivery was a new type of tumor targeting drug delivery system.In recent years,the amphiphilic drug delivery system has been widely used in drug delivery and release.Well-defined amphiphilicβ-cyclodextrin(β-CD) star-shaped copolymers with poly(e-caprolactone)-poly(2-(2-methoxyethoxy)ethyl methacrylate)-co-Poly(ethylene glycol) methacrylate)(β-CD-(PCL-P(MEO_2MA-co-PEGMA))_(21) were synthesized via ring opening polymerization(ROP) and transfer radical polymerization(ATRP).The copolymer can be loaded hydrophobic anticancer drugs,with the process of self-assembly.The drug carrier composite nanoparticles into the loop body,carrier to the tumor cells by the EPR effect.In the special environment of the tumor cells,the thermo-sensitive groups will rupture,causing the micelle structure was destroyed and the entrapped drug of the release.Cell activity and CLSM experiment showed low toxicity of copolymers,the encapsulation of doxorubicin(DOX) after the effective cell inhibitory effect and the vector carrying anticancer drug doxorubicin and effective control of drug release.Therefore,the amphiphilic copolymer micelles could be used as potential drug and gene carrier.
引文
[1]Li,L.;Lu,B,B.;Guo,X,H.;and Liu,Z,Y.RSC Adv.,2016,6,27102-27112.
[2]Nicolas,J.L.;Mura,S.;Mackiewicz N.;and P.Couvreur.Chem Soc Rev,2013,42,1147-1235.
[2]Nicolas,J.L.;Mura,S.;Mackiewicz N.;and P.Couvreur.Chem Soc Rev,2013,42,1147-1235.