摘要
伴随着年龄增长,各种老化特征相继而来。尤其是女性绝经后衰老表现尤为明显,皮肤由于失去弹性而变薄,导致皮肤下垂,皱纹变得醒目。而是否显老,还与代表性雌性激素17-β雌二醇密切相关,众所周知,17-β雌二醇随着年龄增长不断减少,绝经后体内含有水平更是急剧下降。"多功能蛋白聚糖"能够促进细胞分裂,在创伤修复以及胎儿皮肤形成时期表达量明显亢进。由此,本研究着眼于皮肤再生所必需的人体成分"多功能蛋白聚糖",探究了其通过17-β雌二醇的控制,从而对皮肤老化产生影响的可能性。为化妆品功能性成分研发构筑了理论依据。
Women feel several aging symptoms with aging,especially the symptoms become more remarkable after menopause,and the skin become thinner with decreasing the skin elasticity,resulting in the appearances of wrinkles and sagging.17-β-estradiol is one of the principle sex-hormones decreasing with age,and the secretion is also affected by menopause.The difference between actual and apparent ages is known to be strongly affected by the serum level of 17-β-estradiol.This study elucidated the mechanism of skin alteration in aged and perimenopausal women and found a key strategy allowing cosmetic chemists to find potent anti-aging ingredients with focusing on versican as a target for a skin-rejuvenation strategy.Versican is known to accelerate cell motility and proliferation and up-regulated during wound healing and fatal period,suggesting that versican is involved in the systematic skin regeneration.The finding suggests that versican might act as a potent player in skin rejuvenation not only for postmenopausal woman but also premenopausal woman.
引文
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