ST6Gal-I Modulates Docetaxel Sensitivity in Human Hepatocarcinoma Cells via the p38 MAPK/caspase Pathway
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- 英文论文题名：ST6Gal-I Modulates Docetaxel Sensitivity in Human Hepatocarcinoma Cells via the p38 MAPK/caspase Pathway
- 论文作者：Xixi Chen ; Liping Wang ; Yujie Zhao ; Shiqi Yuan ; Qiang Wu ; Xiaoling Zhu ; Bachir Niang ; Shujing Wang ; Jianing Zhang
- 英文论文作者：Xixi Chen ; Liping Wang ; Yujie Zhao ; Shiqi Yuan ; Qiang Wu ; Xiaoling Zhu ; Bachir Niang ; Shujing Wang ; Jianing Zhang ; School of Life Science and Medicine ; Dalian University of Technology ; Department of Biochemistry ; Institute of Glycobiology ; Dalian Medical University
- 年：2016
- 作者机构：School of Life Science and Medicine, Dalian University of Technology;Department of Biochemistry, Institute of Glycobiology, Dalian Medical University;
- 英文论文关键词：HCC ; ST6Gal-I ; Docetaxel ; Apoptosis ; p38 MAPK
- 会议召开时间：2016-10-20
- 会议录名称：中国生物化学与分子生物学会2016年全国学术会议论文集
- 语种：英文
- 分类号：R735.7
- 学会代码：IGSS
- 会议名称：中国生物化学与分子生物学会2016年全国学术会议
- 会议地点：中国浙江杭州
- 主办单位：中国生物化学与分子生物学会
- 学会名称：中国生物化学与分子生物学会
- 页数：1
- 文件大小：6865k
- 原文格式：D
- 会议级别：全国
摘要
<正>The The β-galactosideα2-6-sialyltransferase 1(ST6Gal-I)is the principal sialyltransferase responsible for the addition ofα2-6-sialic acid to the termini N-glycans on cell surface.Although ST6Gal-I in cancer cell resistance to chemotherapeutics agents has been previously reported,the role of ST6Gal-I in clinical drug resistance of hepatocellular carcinoma(HCC)is not fully understood.In this study,we found that knockdown of ST6Gal-I increased the sensitivity of hepatocarcinoma MHCC97-H
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