Mediator links the jasmonate receptor to transcriptionally active chromatin
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- 英文论文题名：Mediator links the jasmonate receptor to transcriptionally active chromatin
- 论文作者：Lin Li ; Cunpeng An ; Qingzhe Zhai ; Chaunyou Li
- 英文论文作者：Lin Li ; Cunpeng An ; Qingzhe Zhai ; Chaunyou Li ; State Key Laboratory of Plant Genomics ; Institute of Genetics and Developmental Biology ; Chinese Academy of Sciences
- 年：2016
- 作者机构：State Key Laboratory of Plant Genomics,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences;
- 英文论文关键词：jasmonate ; Mediator ; transcriptional regulation ; HAC1
- 会议召开时间：2016-10-09
- 会议录名称：2016年全国植物生物学大会摘要集
- 语种：英文
- 分类号：Q943.2
- 学会代码：ZGZO
- 会议名称：2016年全国植物生物学大会
- 会议地点：中国湖北武汉
- 主办单位：中国遗传学会、中国细胞生物学学会、中国植物学会、中国植物生理与植物分子生物学学会、中国作物学会
- 学会名称：中国植物学会
- 页数：1
- 文件大小：839k
- 原文格式：D
- 会议级别：全国
摘要
A major progress in our understanding of the jasmonate signaling is that the perception of the active hormone by the E3 ubiquitin ligase SCFCOI1 is tightly linked to genome-wide transcriptional reprogramming that is regulated by the master transcription factor MYC2. However,it remains unclear how the jasmonate receptor transmits regulatory information to RNA polymerase II to specifically transcribe jasmonate-responsive genes. Here we report that the MED25 subunit of the Arabidopsis Mediator provides an interface for interactions of COI1,MYC2 and the histone acetyltransferase HAC1 at the core promoters of MYC2 targets. Our results unravel a mechanism of how Mediator channels hormone-specific regulatory signals to the Pol II general transcription machinery and highlight the ability of Mediator in coordinating gene expression programs of diverse signaling pathways.
A major progress in our understanding of the jasmonate signaling is that the perception of the active hormone by the E3 ubiquitin ligase SCFCOI1 is tightly linked to genome-wide transcriptional reprogramming that is regulated by the master transcription factor MYC2. However,it remains unclear how the jasmonate receptor transmits regulatory information to RNA polymerase II to specifically transcribe jasmonate-responsive genes. Here we report that the MED25 subunit of the Arabidopsis Mediator provides an interface for interactions of COI1,MYC2 and the histone acetyltransferase HAC1 at the core promoters of MYC2 targets. Our results unravel a mechanism of how Mediator channels hormone-specific regulatory signals to the Pol II general transcription machinery and highlight the ability of Mediator in coordinating gene expression programs of diverse signaling pathways.
A major progress in our understanding of the jasmonate signaling is that the perception of the active hormone by the E3 ubiquitin ligase SCFCOI1 is tightly linked to genome-wide transcriptional reprogramming that is regulated by the master transcription factor MYC2. However,it remains unclear how the jasmonate receptor transmits regulatory information to RNA polymerase II to specifically transcribe jasmonate-responsive genes. Here we report that the MED25 subunit of the Arabidopsis Mediator provides an interface for interactions of COI1,MYC2 and the histone acetyltransferase HAC1 at the core promoters of MYC2 targets. Our results unravel a mechanism of how Mediator channels hormone-specific regulatory signals to the Pol II general transcription machinery and highlight the ability of Mediator in coordinating gene expression programs of diverse signaling pathways.
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