TIPE2 in Dendritic Cells Promotes T Cell Activation and Inhibits the Induction of pTreg
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- 英文论文题名：TIPE2 in Dendritic Cells Promotes T Cell Activation and Inhibits the Induction of pTreg
- 论文作者：Liu Ruiling ; Fang Tingting ; Geng Wenwen ; Ruan Qingguo
- 英文论文作者：Liu Ruiling ; Fang Tingting ; Geng Wenwen ; Ruan Qingguo ; Shenzhen Institutes of Advanced Technology ; Chinese Academy of Sciences
- 年：2016
- 作者机构：Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences;
- 英文论文关键词：TIPE2 ; pTreg ; Dendritic cells ; PI3K ; Phosphoinositide
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会摘要汇编
- 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R392
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：2
- 文件大小：1335k
- 原文格式：D
- 会议级别：全国
摘要
Dendritic cells(DCs) are specialized antigen-presenting cells. Their function is to process antigen and present it on the cell surface to the T cells and act as messengers between the innate and the adaptive immune systems. In addition to their function as potent stimulators of adaptive immunity, DCs are also crucial for immunological tolerance, at least in part, through the induction of peripheral regulatory T cells(p Tregs). Tumor necrosis factor-α-induced protein 8-2(Tumor necrosis factor-α induced protein-8-like 2, TNFAIP8L2 or TIPE2) was expressed primarily by immune cells and maintains immune tolerance through the negative regulation of innate and adaptive immune responses. A previous study indicates that TIPE2 in DCs may inhibit the innate immune response to RNA by targeting the Phosphatidylinositol 3-Kinase(PI3K)-Rac pathway. However, the role of TIPE2 in DCs in the adaptive immune response remains incompletely understood. Our current study showed that, although TIPE2 in T cells inhibits their activation, TIPE2 in DCs unexpectedly promotes T cell activation. Mechanistic studies revealed that TIPE2 promotes DC maturation through the PI3K-PKC-MAPK signaling pathway. In addition, Tipe2-deficiency promotes the induction and function of CD8~+CD25~+Foxp3+ p Tregs in the gut mucosa. Taken together, these results indicate that, in addition to acting as a negative regulator of the immune response, TIPE2 in DCs is also capable of promoting adaptive immunity through PI3K-PKC-MAPK signaling pathway and may play important roles during the elimination of pathogens and the pathogenesis of autoimmune and inflammatory diseases.
Dendritic cells(DCs) are specialized antigen-presenting cells. Their function is to process antigen and present it on the cell surface to the T cells and act as messengers between the innate and the adaptive immune systems. In addition to their function as potent stimulators of adaptive immunity, DCs are also crucial for immunological tolerance, at least in part, through the induction of peripheral regulatory T cells(pTregs). Tumor necrosis factor-α-induced protein 8-2(Tumor necrosis factor-α induced protein-8-like 2, TNFAIP8L2 or TIPE2) was expressed primarily by immune cells and maintains immune tolerance through the negative regulation of innate and adaptive immune responses. A previous study indicates that TIPE2 in DCs may inhibit the innate immune response to RNA by targeting the Phosphatidylinositol 3-Kinase(PI3K)-Rac pathway. However, the role of TIPE2 in DCs in the adaptive immune response remains incompletely understood. Our current study showed that, although TIPE2 in T cells inhibits their activation, TIPE2 in DCs unexpectedly promotes T cell activation. Mechanistic studies revealed that TIPE2 promotes DC maturation through the PI3K-PKC-MAPK signaling pathway. In addition, Tipe2-deficiency promotes the induction and function of CD4+CD25~+Foxp3+ p Tregs in the gut mucosa. Taken together, these results indicate that, in addition to acting as a negative regulator of the immune response, TIPE2 in DCs is also capable of promoting adaptive immunity through PI3K-PKC-MAPK signaling pathway and may play important roles during the elimination of pathogens and the pathogenesis of autoimmune and inflammatory diseases.
Dendritic cells(DCs) are specialized antigen-presenting cells. Their function is to process antigen and present it on the cell surface to the T cells and act as messengers between the innate and the adaptive immune systems. In addition to their function as potent stimulators of adaptive immunity, DCs are also crucial for immunological tolerance, at least in part, through the induction of peripheral regulatory T cells(pTregs). Tumor necrosis factor-α-induced protein 8-2(Tumor necrosis factor-α induced protein-8-like 2, TNFAIP8L2 or TIPE2) was expressed primarily by immune cells and maintains immune tolerance through the negative regulation of innate and adaptive immune responses. A previous study indicates that TIPE2 in DCs may inhibit the innate immune response to RNA by targeting the Phosphatidylinositol 3-Kinase(PI3K)-Rac pathway. However, the role of TIPE2 in DCs in the adaptive immune response remains incompletely understood. Our current study showed that, although TIPE2 in T cells inhibits their activation, TIPE2 in DCs unexpectedly promotes T cell activation. Mechanistic studies revealed that TIPE2 promotes DC maturation through the PI3K-PKC-MAPK signaling pathway. In addition, Tipe2-deficiency promotes the induction and function of CD4+CD25~+Foxp3+ p Tregs in the gut mucosa. Taken together, these results indicate that, in addition to acting as a negative regulator of the immune response, TIPE2 in DCs is also capable of promoting adaptive immunity through PI3K-PKC-MAPK signaling pathway and may play important roles during the elimination of pathogens and the pathogenesis of autoimmune and inflammatory diseases.
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