摘要
<正>Interactions with the immune system may lead tumorigenic cells into immunologic dormancy.However,the underlying molecular mechanism is poorly understood.By using a 3D fibrin gel model,we show that IFN-βinduces tumor-repopulating cells(TRC)to enter dormancy through an IDO-Kyn-Ah R-p27 dependent pathway.Blocking this metabolic circuitry can abrogate IFN-β-induced dormancy of TRCs in melanoma.Revelation of this previously
引文