MARVELD1 regulates cellular stress response and cell death in reproductive cancers
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摘要
<正>Elevated ROS generation leads to increased oxidative stress in cancer cells,which stimulates cellular proliferation,promotes cancer development and alters cellular sensitivity to antitumor agents.Oncogenic signals and malfunction of the mitochondrial respiratory chain are the commonest causes of the increased ROS production in cancer.In this study,we found tumor suppressor gene MARVELD1 was inactivated in reproductive cancers,and MARVELD1 expression level was reverse
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