Folate-Modified Chitosan Nanoparticles Coated InterferonInducible Protein-10 Gene Enhance Cytotoxic T Lymphocytes' Responses to Hepatocellular Carcinoma
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摘要
<正>Purpose:To improve the efficacy of adoptive immunotherapy,we aimed to develop a novel therapy approach to increase the concentration of tumor antigen-specific CTLs in tumor tissues and improve their anti-tumor activities.Method:Chitosan nanoparticles were prepared using the ion template method,then folate and carbodiimide were then combined in a beaker and mixed in the dark using a magnetic stirrer for 1 h.The diluted h IP-10 plasmid
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