IFN-β-induced tumor dormancy by regulating IDO1-AhR pathway
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- 英文论文题名：IFN-β-induced tumor dormancy by regulating IDO1-AhR pathway
- 论文作者：Liu Yuying ; Lv Jiadi ; Liang Xiaoyu ; Yin Xiaonan ; Tang Ke ; Ma Jingwei ; Ji Tiantian ; Zhang Huafeng ; Dong Wenqian ; Jin Xun ; Chen Degao ; Lu Jinzhi ; Hu Zhuowei ; Cao Xuetao ; Qin Xiaofeng ; Huang Bo
- 英文论文作者：Liu Yuying ; Lv Jiadi ; Liang Xiaoyu ; Yin Xiaonan ; Tang Ke ; Ma Jingwei ; Ji Tiantian ; Zhang Huafeng ; Dong Wenqian ; Jin Xun ; Chen Degao ; Lu Jinzhi ; Hu Zhuowei ; Cao Xuetao ; Qin Xiaofeng ; Huang Bo ; National Key Laboratory of Medical Molecular Biology & Department of Immunology ; Institute of Basic Medical Sciences ; Clinical Immunology Center ; Chinese Academy of Medical Sciences ; Department of Biochemistry & Molecular Biology ; Tongji Medical College ; Huazhong University of Science & Technology ; Molecular Immunology and Pharmacology Group ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines ; Institute of Materia Medica ; Chinese Academy of Medical Sciences &Peking Union Medical College ; Center of Systems Medicine ; Institute of Basic Medical Sciences ; Chinese Academy of Medical Sciences& Peking Union Medical College ; Beijing ; 200005 ; China ; Suzhou Institute of Systems Medicine
- 年：2016
- 作者机构：National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Clinical Immunology Center, Chinese Academy of Medical Sciences;Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology;Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &Peking Union Medical College;Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences& Peking Union Medical College, Beijing, 200005, China, Suzhou Institute of Systems Medicine;
- 英文论文关键词：IFN-β ; tumorigenic cell ; immunologic dormancy ; molecular mechanism ; immunotherapy
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会分会场交流报告集
- 英文会议录名称：Proceedings of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R730.3
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：254k
- 原文格式：D
- 会议级别：全国
摘要
<正>Interactions with the immune system may lead tumorigenic cells into immunologic dormancy.However,the underlying molecular mechanism is poorly understood.By using a 3D fibrin gel model,we show that IFN-βinduces tumor-repopulating cells(TRC)to enter dormancy through an IDO-Kyn-Ah R-p27 dependent pathway.Blocking this metabolic circuitry can abrogate IFN-β-induced dormancy of TRCs in melanoma.Revelation of this previously
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