基于荧光硅纳米颗粒的纳米载体在长程细胞成像和癌症治疗中的研究
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- 英文论文题名：Fluorescence Silicon Nanoparticle-based Nanocarriers for Long-Term Tumor Cell Imaging and Cancer Therapy
- 论文作者：季晓媛 ; 何耀 ; Fei Peng ; Yuanyuan Su
- 英文论文作者：Xiaoyuan Ji ; Fei Peng ; Yuanyuan Su ; Yao He ; Institute of Functional Nano & Soft Materials (FUNSOM) & Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices ; and Collaborative Innovation Center of Suzhou Nano Science and Technology ; Soochow University
- 年：2016
- 作者机构：苏州大学功能纳米与软物质研究院江苏省碳基功能材料与器件高技术研究重点实验室苏州纳米科技协同创新中心;
- 论文关键词：硅纳米颗粒 ; 细胞成像 ; 癌症治疗 ; 基因转染
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：R730.5;TB383.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：232k
- 原文格式：D
- 会议级别：全国
摘要
荧光硅纳米颗粒由于其独特的光学性质和良好的生物相容性得到广泛的关注。我们发展了一种通过一步法合成的基于硅纳米颗粒的具有荧光、光稳定性、尺寸小(~4 nm)的纳米药物载体[1]。这种硅纳米颗粒的纳米载体具有强荧光、超小尺寸、强的光稳定性和可修饰性。我们总结了基于硅纳米颗粒的荧光探针的最新工作,突出为生物探针在长程细胞成像、示踪以及作为新型的治疗工具应用于癌症治疗领域、基因转染领域的进展[2-4]。
Fluorescent silicon nanoparticles(Si NPs) are especially interesting due to their unique optical properties and favourable biocompatibility. We develop a fluorescent and photostable, small-sized(~ 4 nm) drug nanocarrier based on SiNPs facilely prepared via a one-step procedure. The SiNPs nanocarriers feature strong fluorescence, ultra-small size, robust photostability, and tuneable drug-loading capacity. Herein, we summarize representative and promising achievement in the field of long-term tracking, cancer therapy and gene transfection using the SiNPs-based fluorescence nanocarriers.
Fluorescent silicon nanoparticles(Si NPs) are especially interesting due to their unique optical properties and favourable biocompatibility. We develop a fluorescent and photostable, small-sized(~ 4 nm) drug nanocarrier based on SiNPs facilely prepared via a one-step procedure. The SiNPs nanocarriers feature strong fluorescence, ultra-small size, robust photostability, and tuneable drug-loading capacity. Herein, we summarize representative and promising achievement in the field of long-term tracking, cancer therapy and gene transfection using the SiNPs-based fluorescence nanocarriers.
引文
[1]Y.L.Zhong,F.Peng,F.Bao,S.Y.Wang,X.Y.Ji,L.Yang,Y.Y.Su,S.T.Lee,Y.He J.Am.Chem.Soc.2013,135,8350-8356.
[2]X.Y.Ji,F.Peng,Y.L.Zhong,Y.Y.Su,X.X.Jiang,C.X.Song,L.Yang,B.B.Chu,S.T.Lee,Y.He Adv.Mater.2015,27,1029-1034.
[3]C.X.Song,Y.L.Zhong,X.X.Jiang,F.Peng,Y.M.Lu,X.Y.Ji,Y.Y.Su,Y.He Anal.Chem.2015,87,6718-6723.
[4]J.Y.Pang,Y.Y.Su,Y.L.Zhong,F.Peng,B.Song,Y.He Anal.Chem.2016,in revised revision.
[2]X.Y.Ji,F.Peng,Y.L.Zhong,Y.Y.Su,X.X.Jiang,C.X.Song,L.Yang,B.B.Chu,S.T.Lee,Y.He Adv.Mater.2015,27,1029-1034.
[3]C.X.Song,Y.L.Zhong,X.X.Jiang,F.Peng,Y.M.Lu,X.Y.Ji,Y.Y.Su,Y.He Anal.Chem.2015,87,6718-6723.
[4]J.Y.Pang,Y.Y.Su,Y.L.Zhong,F.Peng,B.Song,Y.He Anal.Chem.2016,in revised revision.