EXPERIMENTAL EVALUATION OF BLOCKING EFFECT ON EMBOLI IN THE AORTA ASCENDENS BY USING PHASED ARRAY ULTRASOUND
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- 英文论文题名：EXPERIMENTAL EVALUATION OF BLOCKING EFFECT ON EMBOLI IN THE AORTA ASCENDENS BY USING PHASED ARRAY ULTRASOUND
- 论文作者：Zhen ZHANG ; Kang AN ; Min TANG ; Ya-zhu CHEN ; Jing-feng BAI
- 英文论文作者：Zhen ZHANG ; Kang AN ; Min TANG ; Ya-zhu CHEN ; Jing-feng BAI ; School of Biomedical Engineering ; Shanghai Jiao Tong University ; Department of Cardiothoracic Surgery ; Xinhua Hospital ; School of Medicine ; Shanghai Jiao Tong University
- 年：2016
- 作者机构：School of Biomedical Engineering, Shanghai Jiao Tong University;Department of Cardiothoracic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University;
- 英文论文关键词：Phased array ultrasound ; Ultrasonic radiation force ; Emboli ; Experimental evaluation
- 会议召开时间：2016-10-21
- 会议录名称：2016年全国压电和声波理论及器件应用研讨会论文摘要集
- 英文会议录名称：Abstract Book of 2016 Symposium on Piezoelectricity, Acoustic Waves and Device Applications
- 语种：英文
- 分类号：R654;R445.1
- 学会代码：AGLU
- 会议名称：2016年全国压电和声波理论及器件应用研讨会
- 会议地点：中国陕西西安
- 主办单位：中国力学学会、中国声学学会、IEEE UFFC分会
- 学会名称：中国力学学会
- 页数：2
- 文件大小：90k
- 原文格式：D
- 会议级别：全国
摘要
Background, Motivation and Objective Neurologic complications, such as transient ischemic attack, stroke and cognitive decline, are common complications after cardiac surgery. They can not only disable patient or take away patient's life but also cause heavy financial and mental burden upon the patients and their family. The reason of neurologic complications is related to gaseous and solid emboli of head blood vessel which are generated in extracorporeal circulation and surgical operation. Therefore, it is very meaningful to block gaseous and solid emboli from flowing into head from the right common carotid artery. Ultrasound field can generate ultrasonic radiation force acting on embolic and may block emboli from flowing into some blood vessels. This study is aimed to evaluate the blocking effect of the phased array ultrasound on emboli. Statement of Contribution/Methods We did experiments on eight pigs(40kg). After opening thorax, we positioned ultrasound transducer between aorta ascendens and truncus brachiocephalicus. And emboli were detected by PHILIPS CX50 on the right common carotid artery. Air embolic used every time were created by mixing 1 ml air with 9 ml normal saline and polystyrene particles(Duke Corp) dissolved in normal saline as the solid emboli. Both kinds of emboli were injected in the left auricle 8 times on each pig. 4 times with ultrasound transducer off and 4 times with ultrasound transducer on. The emboli which flowed into the right common carotid artery were detected and analyzed. At the end of the experiment, the sonicated tissue was cut for histopathology test. Results The histopathology test showed that the sonicated tissue was not injured. The use of phased array ultrasound significantly reduced the number of emboli which flowed into the right common carotid artery. The gaseous emboli reduced by 69% and the solid emboli reduced by 61%. Discussion and Conclusions The research revealed that use of phased array ultrasound is a safe way to block emboli from flowing into right common carotid artery and the block effect is significant. If applying the technique to cardiac surgery, it can lower the risk of postoperative neurological complications which is very meaningful. The result showed that the block effect on gaseous emboli is better than solid emboli under the same experiment condition. The reason for that is because gaseous emboli and solid emboli have different acoustic impedance with their surroundings.
Background, Motivation and Objective Neurologic complications, such as transient ischemic attack, stroke and cognitive decline, are common complications after cardiac surgery. They can not only disable patient or take away patient's life but also cause heavy financial and mental burden upon the patients and their family. The reason of neurologic complications is related to gaseous and solid emboli of head blood vessel which are generated in extracorporeal circulation and surgical operation. Therefore, it is very meaningful to block gaseous and solid emboli from flowing into head from the right common carotid artery. Ultrasound field can generate ultrasonic radiation force acting on embolic and may block emboli from flowing into some blood vessels. This study is aimed to evaluate the blocking effect of the phased array ultrasound on emboli. Statement of Contribution/Methods We did experiments on eight pigs(40kg). After opening thorax, we positioned ultrasound transducer between aorta ascendens and truncus brachiocephalicus. And emboli were detected by PHILIPS CX50 on the right common carotid artery. Air embolic used every time were created by mixing 1 ml air with 9 ml normal saline and polystyrene particles(Duke Corp) dissolved in normal saline as the solid emboli. Both kinds of emboli were injected in the left auricle 8 times on each pig. 4 times with ultrasound transducer off and 4 times with ultrasound transducer on. The emboli which flowed into the right common carotid artery were detected and analyzed. At the end of the experiment, the sonicated tissue was cut for histopathology test. Results The histopathology test showed that the sonicated tissue was not injured. The use of phased array ultrasound significantly reduced the number of emboli which flowed into the right common carotid artery. The gaseous emboli reduced by 69% and the solid emboli reduced by 61%. Discussion and Conclusions The research revealed that use of phased array ultrasound is a safe way to block emboli from flowing into right common carotid artery and the block effect is significant. If applying the technique to cardiac surgery, it can lower the risk of postoperative neurological complications which is very meaningful. The result showed that the block effect on gaseous emboli is better than solid emboli under the same experiment condition. The reason for that is because gaseous emboli and solid emboli have different acoustic impedance with their surroundings.
Background, Motivation and Objective Neurologic complications, such as transient ischemic attack, stroke and cognitive decline, are common complications after cardiac surgery. They can not only disable patient or take away patient's life but also cause heavy financial and mental burden upon the patients and their family. The reason of neurologic complications is related to gaseous and solid emboli of head blood vessel which are generated in extracorporeal circulation and surgical operation. Therefore, it is very meaningful to block gaseous and solid emboli from flowing into head from the right common carotid artery. Ultrasound field can generate ultrasonic radiation force acting on embolic and may block emboli from flowing into some blood vessels. This study is aimed to evaluate the blocking effect of the phased array ultrasound on emboli. Statement of Contribution/Methods We did experiments on eight pigs(40kg). After opening thorax, we positioned ultrasound transducer between aorta ascendens and truncus brachiocephalicus. And emboli were detected by PHILIPS CX50 on the right common carotid artery. Air embolic used every time were created by mixing 1 ml air with 9 ml normal saline and polystyrene particles(Duke Corp) dissolved in normal saline as the solid emboli. Both kinds of emboli were injected in the left auricle 8 times on each pig. 4 times with ultrasound transducer off and 4 times with ultrasound transducer on. The emboli which flowed into the right common carotid artery were detected and analyzed. At the end of the experiment, the sonicated tissue was cut for histopathology test. Results The histopathology test showed that the sonicated tissue was not injured. The use of phased array ultrasound significantly reduced the number of emboli which flowed into the right common carotid artery. The gaseous emboli reduced by 69% and the solid emboli reduced by 61%. Discussion and Conclusions The research revealed that use of phased array ultrasound is a safe way to block emboli from flowing into right common carotid artery and the block effect is significant. If applying the technique to cardiac surgery, it can lower the risk of postoperative neurological complications which is very meaningful. The result showed that the block effect on gaseous emboli is better than solid emboli under the same experiment condition. The reason for that is because gaseous emboli and solid emboli have different acoustic impedance with their surroundings.
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