降钙素原在恶性血液病患者中的临床应用
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- 论文作者：温莹
- 年：2016
- 作者机构：解放军第309医院;
- 论文关键词：降钙素原 ; 恶性血液病 ; C反应蛋白
- 英文论文关键词：calcitonin original ; hematologic malignancies ; c-reactive protein
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R733
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：2
- 文件大小：1903k
- 原文格式：D
- 会议级别：全国
摘要
恶性血液病患者由于疾病本身、化疗或造血干细胞移植术后,常伴有免疫力低下,易合并各种感染,已成为患者的主要死因之一[1]。感染的常见病原体为细菌、真菌及病毒,约50%以上的感染是由细菌引起的[2]。恶性血液病患者的细菌感染进展快,发展迅速,易合并感染性休克,从而导致多器官、功能脏器的衰竭甚至死亡。早期的病因诊断及治疗对预后至关重要,但短期内明确感染的病原体比较困难。血培养及其他标本阳性率低,病原菌分离、培养时间长,其他生物学指标高敏C反应蛋白(CRP)、白细胞计数特异性较低。近年来,降钙素原(procalcitionin,PCT)在临床上广泛应用,我们主要探讨PCT在恶性血液病患者中诊断及治疗的意义。
patients with hematologic malignancies due to disease, chemotherapy or hematopoietic stem cell transplantation, often accompanied by low immunity, easily merge infection, has become one of the leading cause of death in patients with [1]. The common pathogen infection of bacteria, fungi and virus, about more than 50% of the infections are caused by bacteria [2].Bacterial infection in patients with hematologic malignancies progress fast, development is rapid, easy combination of septic shock, which can lead to multiple organ, the function of organ failure and even death. The cause of early diagnosis and treatment is very important to prognosis, but in the short term it is difficult to clear infection of pathogens. Blood culture positive rate is low, and other specimen pathogen separation, long training time and other biological indicators high-sensitivity c-reactive protein(CRP) and white blood cell count specificity is low. In recent years, calcitonin original(procalcitionin, PCT) are widely used in clinic, we mainly discuss the PCT in the significance of diagnosis and treatment in patients with hematologic malignancies.
patients with hematologic malignancies due to disease, chemotherapy or hematopoietic stem cell transplantation, often accompanied by low immunity, easily merge infection, has become one of the leading cause of death in patients with [1]. The common pathogen infection of bacteria, fungi and virus, about more than 50% of the infections are caused by bacteria [2].Bacterial infection in patients with hematologic malignancies progress fast, development is rapid, easy combination of septic shock, which can lead to multiple organ, the function of organ failure and even death. The cause of early diagnosis and treatment is very important to prognosis, but in the short term it is difficult to clear infection of pathogens. Blood culture positive rate is low, and other specimen pathogen separation, long training time and other biological indicators high-sensitivity c-reactive protein(CRP) and white blood cell count specificity is low. In recent years, calcitonin original(procalcitionin, PCT) are widely used in clinic, we mainly discuss the PCT in the significance of diagnosis and treatment in patients with hematologic malignancies.
引文
[1]李庆华、郑桂仙、蔡木发,PCT联合CRP在恶性血液病感染中的临床应用[J].中国医药学指南,2012,10(19):156-158
[2]张素平、万鼎铭、曹伟杰、邵运丽、金婷、张媛、石聪聪,降钙素原在恶性血液病化疗中性粒细胞缺乏合并感染中的临床意义[J].肿瘤基础与临床,2012,25(1):17-20
[3]李艳如、王长远,降钙素原与乳酸在老年社区获得性肺炎患者预后评估中的应用[J].临床肺科杂志,2013,18(3):484-485
[4]Dae Yong Kim,Yoon-Seon Lee,Shin Ahn,Yeon Hee Chun,Kyung Soo Lim,The Usefulness of Procalcitonin and C-Reactive Proteinas Early Diagnostic Markers of Bacteremia in Cancer Patients with Febrile Neutropenia,Cancer Res Treat.2011;43(3):176-180
[5]Azevedo JR,Torres OJ,Czeezko NG,et al.Procalcitonin as a progonostic biomarker of severve spesis and spetic shock[J].Rev Col Bras Cir,2012,39(6):456-461
[6]Linscheid P,Seboek D,Nylen ES,et al.In vitro and in vivo calci-tonin I gene expression in parenchymal cells[J].a novel product ofhuman adipose tissue.Endocrinology,2003,144:5578-5584
[7]邹国英、任碧琼、徐飞,等革兰阴性菌感染患者降钙素原的测定[J].国家检验医学杂志,2010,31(5):494-495
[8]Sánchez-Yepes M,Aznar-Oroval E2,Lorente-Alegre P3,García-Lozano T2,PicónRoig I3,Pérez-Ballestero P2,Ortiz-Mu?oz B,Use of procalcitonin and C-reactive protein as infection markers in febrile neutropenic patients undergoing haematopoietic stem cell trans plant[J].Enferm Infecc Microbiol Clin.2014 Aug-Sep;32(7):418-23
[9]Lyu YX,Yu XC,Zhu MY.Comparison of the diagnostic value of procalcitonin and C-reactive protein after hematopoietic stem cell transplantation:a systematic review and metaanalysist[J].Transpl anti Infection Disease.2013 Jun;15(3):290-9
[10]Koya J1,Nannya Y,Ichikawa M,Kurokawa M,The clicinal role of procaclcitonin in hematopoietic SCT[J].Bone Marrow Transplant.2012 Oct;47(10):1326-31
[11]Yasuo Mori,Kohta Miyawaki,Koji Kato,Katsuto Takenaka,Hiromi Iwasaki,Naoki Harada,Toshihiro Miyamoto,Koichi Akashi and Takanori Teshima Diagnostic Value of Serum Procalcitonin and C-reactive Protein for Infections after Allogeneic Hematopoietic Stem Cell Transplantation versus Nontransplant Setting[J].Intern Med 2011,50:2149-2155.
[12]Azarpira N,Ramzi M,Aghdaie M,Daraie M.Procalcitonin and C-reactive protein serum levels after hematopoietic stem-cell trans-plant.Exp Clin Transplant:,2009.7:115-118
[13]Massaro KS1,Macedo R,de Castro BS,Dulley F,Oliveira MS,Yasuda MA,Levin AS,Costa SF,Risk factor for death in hematopoietic stem cell transplantation:are biomarkers useful to foresee the prognosis in this population of patients?Infection,2014(9):375-341
[14]Brodska H,Drabek T,Malickova K,et al.Marked increase ofprocalcitonin after the administration of anti-thymocyte globulin inpatients before hematopoietic stem cell transplantation does notindicate sepsis:a prospective study.Crit Care,2009,13:37-40.
[15]William Shomali,Ray Hachem,Anne-Marie Chaftari,Ying Jiang,Ramez Bahu,Joseph Jabbour,Sammy Raad,Munirah Al Shuaibi,Iba Al Wohoush,and Issam Raad,Can Procalcitonin Distinguish Infectious Fever From Tumor-Related Feverin Non-Neutropenic Cancer Patients?Cancer:2012(12):5283-5289
[16]Mohsen Meidani,Farzin Khorvash,Hojat Abolghasemi,Bahareh Jamali,Procalcitonin and quantitative C reactive protein role in theearly diagnosis of sepsis in patients with febrile neutropenia,2014,8:216-219
[2]张素平、万鼎铭、曹伟杰、邵运丽、金婷、张媛、石聪聪,降钙素原在恶性血液病化疗中性粒细胞缺乏合并感染中的临床意义[J].肿瘤基础与临床,2012,25(1):17-20
[3]李艳如、王长远,降钙素原与乳酸在老年社区获得性肺炎患者预后评估中的应用[J].临床肺科杂志,2013,18(3):484-485
[4]Dae Yong Kim,Yoon-Seon Lee,Shin Ahn,Yeon Hee Chun,Kyung Soo Lim,The Usefulness of Procalcitonin and C-Reactive Proteinas Early Diagnostic Markers of Bacteremia in Cancer Patients with Febrile Neutropenia,Cancer Res Treat.2011;43(3):176-180
[5]Azevedo JR,Torres OJ,Czeezko NG,et al.Procalcitonin as a progonostic biomarker of severve spesis and spetic shock[J].Rev Col Bras Cir,2012,39(6):456-461
[6]Linscheid P,Seboek D,Nylen ES,et al.In vitro and in vivo calci-tonin I gene expression in parenchymal cells[J].a novel product ofhuman adipose tissue.Endocrinology,2003,144:5578-5584
[7]邹国英、任碧琼、徐飞,等革兰阴性菌感染患者降钙素原的测定[J].国家检验医学杂志,2010,31(5):494-495
[8]Sánchez-Yepes M,Aznar-Oroval E2,Lorente-Alegre P3,García-Lozano T2,PicónRoig I3,Pérez-Ballestero P2,Ortiz-Mu?oz B,Use of procalcitonin and C-reactive protein as infection markers in febrile neutropenic patients undergoing haematopoietic stem cell trans plant[J].Enferm Infecc Microbiol Clin.2014 Aug-Sep;32(7):418-23
[9]Lyu YX,Yu XC,Zhu MY.Comparison of the diagnostic value of procalcitonin and C-reactive protein after hematopoietic stem cell transplantation:a systematic review and metaanalysist[J].Transpl anti Infection Disease.2013 Jun;15(3):290-9
[10]Koya J1,Nannya Y,Ichikawa M,Kurokawa M,The clicinal role of procaclcitonin in hematopoietic SCT[J].Bone Marrow Transplant.2012 Oct;47(10):1326-31
[11]Yasuo Mori,Kohta Miyawaki,Koji Kato,Katsuto Takenaka,Hiromi Iwasaki,Naoki Harada,Toshihiro Miyamoto,Koichi Akashi and Takanori Teshima Diagnostic Value of Serum Procalcitonin and C-reactive Protein for Infections after Allogeneic Hematopoietic Stem Cell Transplantation versus Nontransplant Setting[J].Intern Med 2011,50:2149-2155.
[12]Azarpira N,Ramzi M,Aghdaie M,Daraie M.Procalcitonin and C-reactive protein serum levels after hematopoietic stem-cell trans-plant.Exp Clin Transplant:,2009.7:115-118
[13]Massaro KS1,Macedo R,de Castro BS,Dulley F,Oliveira MS,Yasuda MA,Levin AS,Costa SF,Risk factor for death in hematopoietic stem cell transplantation:are biomarkers useful to foresee the prognosis in this population of patients?Infection,2014(9):375-341
[14]Brodska H,Drabek T,Malickova K,et al.Marked increase ofprocalcitonin after the administration of anti-thymocyte globulin inpatients before hematopoietic stem cell transplantation does notindicate sepsis:a prospective study.Crit Care,2009,13:37-40.
[15]William Shomali,Ray Hachem,Anne-Marie Chaftari,Ying Jiang,Ramez Bahu,Joseph Jabbour,Sammy Raad,Munirah Al Shuaibi,Iba Al Wohoush,and Issam Raad,Can Procalcitonin Distinguish Infectious Fever From Tumor-Related Feverin Non-Neutropenic Cancer Patients?Cancer:2012(12):5283-5289
[16]Mohsen Meidani,Farzin Khorvash,Hojat Abolghasemi,Bahareh Jamali,Procalcitonin and quantitative C reactive protein role in theearly diagnosis of sepsis in patients with febrile neutropenia,2014,8:216-219