Heterogeneous Expression of TXR1 Antigens and their Prognostic Significance in Human Breast Carcinoma
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- 英文论文题名：Heterogeneous Expression of TXR1 Antigens and their Prognostic Significance in Human Breast Carcinoma
- 论文作者：sun yuanjie ; yang kun
- 英文论文作者：sun yuanjie ; yang kun ; Department of Immunology ; The Fourth Military Medical University
- 年：2016
- 作者机构：Department of Immunology,The Fourth Military Medical University;
- 英文论文关键词：TXR1 ; Breast Carcinoma ; immunohistochemistry ; Statistical analysis method
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会摘要汇编
- 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R737.9
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：1328k
- 原文格式：D
- 会议级别：全国
摘要
Objective: Breast cancer is the most common cancer among women worldwide yet successful treatment remains a clinical challenge.The goal of this study was to detect the inter tumoral heterogeneity of TXR1 expression and further to analyze their prognostic value.Methods: The intertumoral heterogeneity of cancer/testis antigens was examined by immunohistochemistry using 200 samples from patients with infiltrating ductal breast carcinoma. The expression patterns were classified and correlated with the clinicopathologic variables and outcome of the patients.Results: TXR1 showed punctate, focal and diffuse expression patterns according to the characteristic of its distribution, and showed cytoplasmic, nuclear or combined cytoplasmic and nuclear expression patterns according to its subcellular location.The cancer/testis TXR1 antigens were also observed coordinately expressed in infiltrating ductal breast carcinoma. Patients that TXR1 expression was significantly correlated with nodal metastases(P, 0.001) and advanced clinical stages(P ,0.001). In addition, Kaplan–Meier analysis revealed that diffuse TXR1 expression and coexpression was related to the poor prognosis of patients with infiltrating ductal breast carcinoma.Conclusions: Diffuse TXR1 expression and the coexpression of this cancer/testis antigens can be used as a biomarker to distinguish patients with a poorer outcome of the breast carcinoma. Our finding may provide useful data for evaluating the prognosis of this disease and improving the effectiveness of therapeutic application based on this cancer/testis antigens.
Objective: Breast cancer is the most common cancer among women worldwide yet successful treatment remains a clinical challenge.The goal of this study was to detect the inter tumoral heterogeneity of TXR1 expression and further to analyze their prognostic value.Methods: The intertumoral heterogeneity of cancer/testis antigens was examined by immunohistochemistry using 200 samples from patients with infiltrating ductal breast carcinoma. The expression patterns were classified and correlated with the clinicopathologic variables and outcome of the patients.Results: TXR1 showed punctate, focal and diffuse expression patterns according to the characteristic of its distribution, and showed cytoplasmic, nuclear or combined cytoplasmic and nuclear expression patterns according to its subcellular location.The cancer/testis TXR1 antigens were also observed coordinately expressed in infiltrating ductal breast carcinoma. Patients that TXR1 expression was significantly correlated with nodal metastases(P, 0.001) and advanced clinical stages(P ,0.001). In addition, Kaplan–Meier analysis revealed that diffuse TXR1 expression and coexpression was related to the poor prognosis of patients with infiltrating ductal breast carcinoma.Conclusions: Diffuse TXR1 expression and the coexpression of this cancer/testis antigens can be used as a biomarker to distinguish patients with a poorer outcome of the breast carcinoma. Our finding may provide useful data for evaluating the prognosis of this disease and improving the effectiveness of therapeutic application based on this cancer/testis antigens.
Objective: Breast cancer is the most common cancer among women worldwide yet successful treatment remains a clinical challenge.The goal of this study was to detect the inter tumoral heterogeneity of TXR1 expression and further to analyze their prognostic value.Methods: The intertumoral heterogeneity of cancer/testis antigens was examined by immunohistochemistry using 200 samples from patients with infiltrating ductal breast carcinoma. The expression patterns were classified and correlated with the clinicopathologic variables and outcome of the patients.Results: TXR1 showed punctate, focal and diffuse expression patterns according to the characteristic of its distribution, and showed cytoplasmic, nuclear or combined cytoplasmic and nuclear expression patterns according to its subcellular location.The cancer/testis TXR1 antigens were also observed coordinately expressed in infiltrating ductal breast carcinoma. Patients that TXR1 expression was significantly correlated with nodal metastases(P, 0.001) and advanced clinical stages(P ,0.001). In addition, Kaplan–Meier analysis revealed that diffuse TXR1 expression and coexpression was related to the poor prognosis of patients with infiltrating ductal breast carcinoma.Conclusions: Diffuse TXR1 expression and the coexpression of this cancer/testis antigens can be used as a biomarker to distinguish patients with a poorer outcome of the breast carcinoma. Our finding may provide useful data for evaluating the prognosis of this disease and improving the effectiveness of therapeutic application based on this cancer/testis antigens.
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