Metabolomics profiling for Obstructive Sleep Apnea and Simple Snorers
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- 英文论文题名：Metabolomics profiling for Obstructive Sleep Apnea and Simple Snorers
- 论文作者：Huajun Xu ; Xiaojiao Zheng ; Yingjun Qian ; Jian Guan ; Hongliang Yi ; Jianyin Zou ; Yuyu Wang ; Lili Meng ; Aihua Zhao ; Shankai Yin ; Wei Jia
- 英文论文作者：Huajun Xu ; Xiaojiao Zheng ; Yingjun Qian ; Jian Guan ; Hongliang Yi ; Jianyin Zou ; Yuyu Wang ; Lili Meng ; Aihua Zhao ; Shankai Yin ; Wei Jia ; Department of Otolaryngology Head and Neck Surgery&Center of Sleep Medicine ; Shanghai Jiao Tong University Affiliated Sixth People's Hospital ; Otolaryngological Institute of Shanghai Jiao Tong University ; Clinical Research Center ; Shanghai Jiao Tong University School of Medicine ; Center for Translational Medicine ; Shanghai Jiao Tong University Affiliated Sixth People's Hospital
- 年：2016
- 作者机构：Department of Otolaryngology Head and Neck Surgery&Center of Sleep Medicine,Shanghai Jiao Tong University Affiliated Sixth People's Hospital;Otolaryngological Institute of Shanghai Jiao Tong University;Clinical Research Center,Shanghai Jiao Tong University School of Medicine;Center for Translational Medicine,Shanghai Jiao Tong University Affiliated Sixth People's Hospital;
- 英文论文关键词：obstructive sleep apnea ; metabolomics ; urine
- 会议召开时间：2016-05-27
- 会议录名称：中国睡眠研究会第九届学术年会汇编
- 语种：英文
- 分类号：R766
- 学会代码：OGSF
- 会议名称：中国睡眠研究会第九届学术年会
- 会议地点：中国上海
- 主办单位：中国睡眠研究会
- 学会名称：中国睡眠研究会
- 页数：1
- 文件大小：1083k
- 原文格式：O
- 会议级别：全国
摘要
Few clinical studies have explored altered urinary metabolite levels in patients with obstructive sleep apnea(OSA).Thus,we applied a metabolomics approach to analyze urinary metabolites in three groups of participants:patients with polysomnography(PSG)-confirmed OSA,simple snorers(SS),and normal subjects.Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and gas chromatography coupled with time-of-flight mass spectrometry were used.A total of 21 and 31 metabolites were differentially expressed in the SS and OSA groups,respectively.Patients with OSA had 18 metabolites different from those with SS.Of the 56 metabolites detected among the 3 groups,24 were consistently higher or lower.A receiver operator curve analysis revealed that the combination of 4-hydroxypentenoic acid,arabinose,glycochenodeoxycholate-3-sulfate,isoleucine,serine,and xanthine produced a moderate diagnostic score with a sensitivity(specificity) of 75%(78%) for distinguishing OSA from those without OSA.The combination of 4-hydroxypentenoic acid,5-dihydrotestosterone sulfate,serine,spermine,and xanthine distinguished OSA from SS with a sensitivity of 85%and specificity of 80%.Multiple metabolites and metabolic pathways associated with SS and OSA were identified using the metabolomics approach,and the altered metabolite signatures could potentially serve as an alternative diagnostic method to PSG.
Few clinical studies have explored altered urinary metabolite levels in patients with obstructive sleep apnea(OSA).Thus,we applied a metabolomics approach to analyze urinary metabolites in three groups of participants:patients with polysomnography(PSG)-confirmed OSA,simple snorers(SS),and normal subjects.Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and gas chromatography coupled with time-of-flight mass spectrometry were used.A total of 21 and 31 metabolites were differentially expressed in the SS and OSA groups,respectively.Patients with OSA had 18 metabolites different from those with SS.Of the 56 metabolites detected among the 3 groups,24 were consistently higher or lower.A receiver operator curve analysis revealed that the combination of 4-hydroxypentenoic acid,arabinose,glycochenodeoxycholate-3-sulfate,isoleucine,serine,and xanthine produced a moderate diagnostic score with a sensitivity(specificity) of 75%(78%) for distinguishing OSA from those without OSA.The combination of 4-hydroxypentenoic acid,5-dihydrotestosterone sulfate,serine,spermine,and xanthine distinguished OSA from SS with a sensitivity of 85%and specificity of 80%.Multiple metabolites and metabolic pathways associated with SS and OSA were identified using the metabolomics approach,and the altered metabolite signatures could potentially serve as an alternative diagnostic method to PSG.
Few clinical studies have explored altered urinary metabolite levels in patients with obstructive sleep apnea(OSA).Thus,we applied a metabolomics approach to analyze urinary metabolites in three groups of participants:patients with polysomnography(PSG)-confirmed OSA,simple snorers(SS),and normal subjects.Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and gas chromatography coupled with time-of-flight mass spectrometry were used.A total of 21 and 31 metabolites were differentially expressed in the SS and OSA groups,respectively.Patients with OSA had 18 metabolites different from those with SS.Of the 56 metabolites detected among the 3 groups,24 were consistently higher or lower.A receiver operator curve analysis revealed that the combination of 4-hydroxypentenoic acid,arabinose,glycochenodeoxycholate-3-sulfate,isoleucine,serine,and xanthine produced a moderate diagnostic score with a sensitivity(specificity) of 75%(78%) for distinguishing OSA from those without OSA.The combination of 4-hydroxypentenoic acid,5-dihydrotestosterone sulfate,serine,spermine,and xanthine distinguished OSA from SS with a sensitivity of 85%and specificity of 80%.Multiple metabolites and metabolic pathways associated with SS and OSA were identified using the metabolomics approach,and the altered metabolite signatures could potentially serve as an alternative diagnostic method to PSG.
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