具有多模式探针功能的双核锌配合物设计合成及其对前列腺癌的成像研究
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- 英文论文题名：Design and Synthesis of binuclear zinc complex with multi-function mode probes and imaging studies of prostate cancer
- 论文作者：苑强涛 ; 李严严 ; 倪天军 ; 杨志军
- 英文论文作者：Qiangtao Yuan ; Yanyan Li ; Tianjun Ni ; Zhijun Yang ; Department of Chemistry ; Xinxiang Medical University
- 年：2016
- 作者机构：新乡医学院化学教研室;
- 论文关键词：分子探针 ; 功能配合物 ; 多模式成像 ; 前列腺癌
- 英文论文关键词：Molecular probe ; Functional complexes ; Multi mode imaging ; Prostate carcinoma
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十八分会：化学生物学
- 语种：中文
- 分类号：O641.4;TQ421.7
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十八分会 ; 化学生物学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：149k
- 原文格式：D
- 会议级别：全国
摘要
荧光、核磁共振(MRI)等不需要对细胞进行均一化处理,就能直接得到分子在生命体系中大量有价值的信息,是现代生命科学研究的前沿与热点。本文通过clink反应将具有靶向结合肿瘤细胞能力的配体与具有荧光、MRI等信号基团结合,从而使被靶向标记的肿瘤细胞发出荧光/MRI信号。以探索多模式显像在检测深层器官癌症如前列腺癌等的应用,为相关疾病诊断、治疗提供依据。
Fluorescence,magnetic resonance imaging(MRI) do not require a uniform treatment of the cells can be obtained directly in living systems molecule lot of valuable information,modern life science research frontier and hot spots.By clink reaction will have the ability to target tumor cell binding ligand with a fluorescent,MRI and other groups combined signal,so that the targeted tumor cells are labeled fluoresce / MRI signal.To explore the multi-mode imaging in the detection of deep organ cancers such as prostate cancer and other applications related to diagnosis and treatment provide the basis.
Fluorescence,magnetic resonance imaging(MRI) do not require a uniform treatment of the cells can be obtained directly in living systems molecule lot of valuable information,modern life science research frontier and hot spots.By clink reaction will have the ability to target tumor cell binding ligand with a fluorescent,MRI and other groups combined signal,so that the targeted tumor cells are labeled fluoresce / MRI signal.To explore the multi-mode imaging in the detection of deep organ cancers such as prostate cancer and other applications related to diagnosis and treatment provide the basis.
引文
[1]Sandip B.,Biswa N.G.,et al.,J.Am.Chem.Soc,2014,136,5543-5546.
[2]Smith B.A.,Akers W.J.,et al.,J.Am.Chem.Soc.,2010,132,67-69.
[2]Smith B.A.,Akers W.J.,et al.,J.Am.Chem.Soc.,2010,132,67-69.