莫沙必利对食管癌术后胸腔胃排空功能的影响
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摘要
目的:食管癌术后,由于上消化道解剖结构的变化,不可避免地引起其生理功能以及神经和体液调节的改变,致使许多患者存在不同程度的厌食、饱腹、嗳气、返流、腹泻、恶心等症状。本实验旨在通过对食管癌切除术后不同时间的患者进行显示子胃排空试验,评价胃肠动力药物对胸胃排空功能的影响,为术后选择用药提供依据。
方法:本实验选取河北医科大学第四医院胸外科2007年1月至2009年1月期间食管中段癌术后复查的患者46例,其中男32例,女14例,年龄43～71岁,平均60.2岁。分为术后观察组和术后用药组,于术后1个月、3个月、6个月和12个月进行显示子胃排空试验。术后观察组患者直接进行显示子胃排空实验,计数进食试验餐后30min、60min、90min、120min的入肠显示子个数;术后用药组患者口服枸橼酸莫沙比利片,每日三次,每次5mg,连续服用两周后进行显示子胃排空检查,计数进食试验餐后30min、60min、90min、120min入肠显示子个数。另设正常对照组进行显示子胃排空试验。
统计学方法:结果应用方差分析法进行统计,数据采用均数±标准差表示( x±s),以P<0.05为在统计学上有显著差异,统计学处理使用SPSS13.0软件(SPSSInc,美国)。
结果:1.进食试验餐后60min、90min、120min后,术后观察组1、3、6、12月的排空速率明显减慢,与正常对照组相比有显著差异(P<0.05)。
2.术后1个月用药组进食试验餐后30min、60min显示子排空结果与术后观察组无差异(P>0.05),进食试验餐后90min、120min术后用药组显示子胃排空较术后观察组加快(P<0.05),但慢于正常对照组(P<0.01)。
3.术后3个月用药组进食试验餐后30min显示子排空结果与术后观察组无差异(P>0.05),进食试验餐后60min,术后用药组较正常对照组胃排空减慢(P=0.04);术后用药组与术后观察组比较无显著差别(P=0.405)。到90min、120min时,术后用药组显示子胃排空较术后观察组明显加快(P<0.05),但仍较正常对照组减慢(P<0.05)。
4.术后6个月用药组进食试验餐后30min显示子排空结果与术后观察组无差异(P>0.05),进食试验餐后60min、90min、120min术后用药组显示子胃排空较术后观察组加快(P<0.01),与正常对照组比较无差异(P>0.05)。
5.术后12个月用药组进食试验餐后30min显示子排空结果与术后观察组无差异(P>0.05),进食试验餐后60min、90min、120min术后用药组显示子胃排空较术后观察组加快(P<0.05),与正常对照组比较无差异(P>0.05)。结论:1.食管中段癌切除术后,胸腔胃对固体食物的排空明显延迟。
2.莫沙比利具有促进去迷走神经支配的胸腔胃排空的作用。
3.随手术后时间的推移,莫沙比利促进胸胃排空的作用更加明显。
Objective: After esophagectomy for cancer, many patients had the symptom of anorexia, abdominal distention, belching, reflux, diarrhoea and nausea because of the destruction of anatomic structure and the alteration of neural and humoral regulation of the upper gastrointastinal tract. It has been reported that these pathophysiological changes of alimentary tract caused these symptoms. In this study, we observed the gastric emptying by radiopaque markers and compare the effect of stomach and intestines kinetic drug on intrathoracic stomach.
Materials and Methods: Forty-six patients who had underwent esophagectomy for esophageal carcinoma at the Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University between January 2007 and January 2009 were selected randomly. They were divided into two groups randomly: group A (n=23) were given 3 times of 5 mg mosapride for 2 weeks and group B (n=23) were given no tablets. There were 32 male and 14 female, with the mean age of 60.2 years. Radiopaque markers examination was conducted in 16 patients at 1 month after surgery, and 10 patients at 3 months, 6 months and 12 months after surgery, respectively. Five healthy volunteers were selected as normal controls, including 3 male and 2 female, with the mean age of 61.2 years. All patients underwent radiopaque markers examination. After the radiopaque markers (Xianshizi, XSZ) were intaken , the numbers of XSZ expelled from stomach were calculated under fluoroscope at 30 minutes, 60 minutes, 90 minutes and 120 minutes.
Resaults: 1. At 60 minutes, 90minutes and 120 minutes, the intrathoracic gastric emptying rates in patients who had underwent esophagectomy for cancer were lower than that of the control group (p<0.05).
2. One month after surgery, there was no significant differences in the all groups (p>0.05) in the gastric emptying of XSZ at 30 minutes and 60 minutes. At 90 minutes and 120 minutes, the gastric emptying rates in Group A were higher than that of Group B (p<0.05), but lower than that of normal controls (p<0.01).
3. Three months after surgery, there was no significant differences in all the groups (p>0.05) in the gastric emptying at 30 minutes. There was no statistical differences in gastric emptying rates at 60 minutes between group A and B. At 90 minutes and 120 minutes, the gastric emptying rates in Group A were higher than that of Group B (p<0.05), but lower than that in normal control group (p<0.05).
4. Six months after surgery, there was no significant differences in all the groups in gastric emptying of XSZ at 30 minutes (p>0.05). At 60 minutes, 90 minutes and 120 minutes, the gastric emptying rates in Group A were higher than that of Group B (p<0.01), but there was no significant differences between Group A and normal controls (p>0.05).
5. Twelve months after surgery, there was no significant differences in all the groups (p>0.05) in gastric emptying of XSZ at 30 minutes. At 60 minutes, 90 minutes and 120 minutes, the gastric emptying rates of Group A were higher than that of Group B (p<0.05), but there was no significant differences between Group A and normal controls (p>0.05).
Conclusions: 1. The emptying of the intrathoracic stomach was delayed after esophagectomy for cancer.
2. Mosapride improves the intrathoracic gastric emptying after esophagectomy for cancer.
3. The effect of mosapride on the improvement of intrathoracic gastric emptying increase over time.
方法:本实验选取河北医科大学第四医院胸外科2007年1月至2009年1月期间食管中段癌术后复查的患者46例,其中男32例,女14例,年龄43～71岁,平均60.2岁。分为术后观察组和术后用药组,于术后1个月、3个月、6个月和12个月进行显示子胃排空试验。术后观察组患者直接进行显示子胃排空实验,计数进食试验餐后30min、60min、90min、120min的入肠显示子个数;术后用药组患者口服枸橼酸莫沙比利片,每日三次,每次5mg,连续服用两周后进行显示子胃排空检查,计数进食试验餐后30min、60min、90min、120min入肠显示子个数。另设正常对照组进行显示子胃排空试验。
统计学方法:结果应用方差分析法进行统计,数据采用均数±标准差表示( x±s),以P<0.05为在统计学上有显著差异,统计学处理使用SPSS13.0软件(SPSSInc,美国)。
结果:1.进食试验餐后60min、90min、120min后,术后观察组1、3、6、12月的排空速率明显减慢,与正常对照组相比有显著差异(P<0.05)。
2.术后1个月用药组进食试验餐后30min、60min显示子排空结果与术后观察组无差异(P>0.05),进食试验餐后90min、120min术后用药组显示子胃排空较术后观察组加快(P<0.05),但慢于正常对照组(P<0.01)。
3.术后3个月用药组进食试验餐后30min显示子排空结果与术后观察组无差异(P>0.05),进食试验餐后60min,术后用药组较正常对照组胃排空减慢(P=0.04);术后用药组与术后观察组比较无显著差别(P=0.405)。到90min、120min时,术后用药组显示子胃排空较术后观察组明显加快(P<0.05),但仍较正常对照组减慢(P<0.05)。
4.术后6个月用药组进食试验餐后30min显示子排空结果与术后观察组无差异(P>0.05),进食试验餐后60min、90min、120min术后用药组显示子胃排空较术后观察组加快(P<0.01),与正常对照组比较无差异(P>0.05)。
5.术后12个月用药组进食试验餐后30min显示子排空结果与术后观察组无差异(P>0.05),进食试验餐后60min、90min、120min术后用药组显示子胃排空较术后观察组加快(P<0.05),与正常对照组比较无差异(P>0.05)。结论:1.食管中段癌切除术后,胸腔胃对固体食物的排空明显延迟。
2.莫沙比利具有促进去迷走神经支配的胸腔胃排空的作用。
3.随手术后时间的推移,莫沙比利促进胸胃排空的作用更加明显。
Objective: After esophagectomy for cancer, many patients had the symptom of anorexia, abdominal distention, belching, reflux, diarrhoea and nausea because of the destruction of anatomic structure and the alteration of neural and humoral regulation of the upper gastrointastinal tract. It has been reported that these pathophysiological changes of alimentary tract caused these symptoms. In this study, we observed the gastric emptying by radiopaque markers and compare the effect of stomach and intestines kinetic drug on intrathoracic stomach.
Materials and Methods: Forty-six patients who had underwent esophagectomy for esophageal carcinoma at the Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University between January 2007 and January 2009 were selected randomly. They were divided into two groups randomly: group A (n=23) were given 3 times of 5 mg mosapride for 2 weeks and group B (n=23) were given no tablets. There were 32 male and 14 female, with the mean age of 60.2 years. Radiopaque markers examination was conducted in 16 patients at 1 month after surgery, and 10 patients at 3 months, 6 months and 12 months after surgery, respectively. Five healthy volunteers were selected as normal controls, including 3 male and 2 female, with the mean age of 61.2 years. All patients underwent radiopaque markers examination. After the radiopaque markers (Xianshizi, XSZ) were intaken , the numbers of XSZ expelled from stomach were calculated under fluoroscope at 30 minutes, 60 minutes, 90 minutes and 120 minutes.
Resaults: 1. At 60 minutes, 90minutes and 120 minutes, the intrathoracic gastric emptying rates in patients who had underwent esophagectomy for cancer were lower than that of the control group (p<0.05).
2. One month after surgery, there was no significant differences in the all groups (p>0.05) in the gastric emptying of XSZ at 30 minutes and 60 minutes. At 90 minutes and 120 minutes, the gastric emptying rates in Group A were higher than that of Group B (p<0.05), but lower than that of normal controls (p<0.01).
3. Three months after surgery, there was no significant differences in all the groups (p>0.05) in the gastric emptying at 30 minutes. There was no statistical differences in gastric emptying rates at 60 minutes between group A and B. At 90 minutes and 120 minutes, the gastric emptying rates in Group A were higher than that of Group B (p<0.05), but lower than that in normal control group (p<0.05).
4. Six months after surgery, there was no significant differences in all the groups in gastric emptying of XSZ at 30 minutes (p>0.05). At 60 minutes, 90 minutes and 120 minutes, the gastric emptying rates in Group A were higher than that of Group B (p<0.01), but there was no significant differences between Group A and normal controls (p>0.05).
5. Twelve months after surgery, there was no significant differences in all the groups (p>0.05) in gastric emptying of XSZ at 30 minutes. At 60 minutes, 90 minutes and 120 minutes, the gastric emptying rates of Group A were higher than that of Group B (p<0.05), but there was no significant differences between Group A and normal controls (p>0.05).
Conclusions: 1. The emptying of the intrathoracic stomach was delayed after esophagectomy for cancer.
2. Mosapride improves the intrathoracic gastric emptying after esophagectomy for cancer.
3. The effect of mosapride on the improvement of intrathoracic gastric emptying increase over time.
引文
1王其彰,张毓德,杜喜群,等.食管癌切除后重建食管的测压观察.中华外科杂志,1988,26(5):305-307
2刘琳,唐谨,王永岗,等.颈、胸段食管癌术后的核素胃排空检查.中华核医学杂志, 1994, 14:137-139
3候浚,张国生,刘恬格,等. 1990～1992河北省21县癌症死亡率分析[J].河北医药, 1995, 17(5): 20-38
4 Holle GE, Hahn D, Forth W. Innervation of pylorus in control of motility and gastric emptying[J]. Am J physiol, 1992, 263(25): 161-168
5 Grider J, River J. Vasoactive intestinal polypeptide(VIP) as transmitter of inhibitory motor neurons of the gut: Evidence from the use of selective VIP antiserem[J]. J Pharmacol Exp Ther, 1990, 253(2): 738-742
6 Hinton J, Lennard J, Yong A. A new method for studying gut transit time using radiopaque markers[J], Gut, 1967, 10:842-847
7陈延,王学勤,戴菲,等.不透X线标记物检测胃肠道运动的临床应用[J].实用放射学杂志, 2001, 17(9): 647-650
8王其彰,王如然,马立敏,等.显示子用于检查食管癌切除术后胃排空[J].中华外科杂志, 2000, 38(7): 529-530
9王永岗,张汝刚,张大为,等.食管癌术后胸胃功能的研究[J].中华肿瘤杂志, 1997, 19(5): 385-388
10王其彰,王起民,张长保,等.食管癌切除术后胃排空[J].中华肿瘤杂志, 1988, 10(4): 301-303
11刘俊峰,王金栋,张少为,等.食管癌与贲门癌患者术后残余食管与胸腔胃功能的研究[J].中华医学杂志, 2005, 85(38): 2678-2681
12王士杰,王其彰,主编.食管癌与贲门癌[M].北京:人民卫生出版社, 2008: 252
13王其彰,张长保,李保庆,等.食管癌切除术后双相胃排空[J].中华胸心血管外科杂志, 1999, 15(6): 335-336
14 Kelly KA. Gastric emptying disorders following gastric surgery. In: Dubois A, Castell DO, eds. Esophageal and gastric emptying[M]. Boca Raton: CRC Press, 1984: 89-94
15 Mannell A, Hinder RH, San-Garde BH, et al. The thoracic stomach: a study of gastric emptying, bile reflux and mucosal change[J]. Br J Surg, 1984, 71(6): 438-441
16陈新谦,金有豫,汤光.新编药物学[M].第16版.北京:人民卫生出版社, 2007: 486
17 Katayama K, Morio Y, Haga K, et al. Cisapride, a gastroprokinetic agent, binds to 5-HT4 receptors[J]. NipponYakurigaku Zasshi, 1995, 105(6): 461-468
18 Mine Y. Yoshikawa T, Oku S, et al. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro[J]. J Pharmacol Exp Ther, 1997, 283(3): 1000-1008
19 Kii Y, Ito T. Effects of 5-HT4-receptor agonists, cisapride, mosapride citrate, and zacopride on cardiac action potentials on guinea pig isolated papillary muscles[J]. J Cardiovasc Pharmacol, 1997, 29(5): 670-675
20金华,张铁军.枸橼酸莫沙比利-新型胃动力药[J].药学进展, 2000, 24(5): 307-308
21 Yoshida N, Ito T, Karasawa T, et al. As-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs[J]. J Pharmacol Exp ther, 1991, 257(2): 781-787
22申屠阳,周允中.胃肠动力剂对术后胸腔胃状态的影响[J].中国胸心血管外科临床杂志, 2000, 7(1): 18-20
23张正斌.莫沙比利治疗食管癌与贲门癌术后胃排空障碍[J].现代中西医结合杂志, 2007, 16(29): 4422
1潘国宗,曹世植,主编.现代胃肠病学[M].北京:科学出版社, 1994: 1352
2王永岗,张汝刚,张大为,等.食管癌术后胸胃功能的研究[J].中华肿瘤杂志, 1997, 19(5): 385-388
3王其彰,王起民,张长保,等.食管癌切除术后胃排空[J].中华肿瘤杂志, 1988, 10(4): 301-303
4刘俊峰,王金栋,张少为,等.食管癌与贲门癌患者术后残余食管与胸腔胃功能的研究[J].中华医学杂志, 2005, 85(38): 2678-2681
5刘琳,唐谨,王永岗,等.颈、胸段食管癌术后的核素胃排空检查[J].中华核医学杂志, 1994, 14(3), 137-139
6 Minaml H, Mccallum RW. The physiology and Pathophysiology of gastric emptying in humans[J].Gastroenterology, 1984, 86(6): 1592-1610
7 Deleyn P, Coosemans W, Lerut. Early and late functional results in patients with intrathoracic gastric replacement after esophagectomy for carcinoma[J]. Eur J Cardiothorac Surg, 1992, 6(2): 79-84
8 Masahiro N. Functioning of the intrathoracic stomach after esophagectomy[J]. Arch Surg, 1994, 129(8): 837
9 Calabuig R, Carrio I, Mones J, et al. Gastric and emptying after truncal vagotomy and pyloroplasty[J]. Scand J Gast roenterol, 1988, 23(6): 659-664
10 Baxter JN, Grime J S, Critchley M, et al. Relationship between gastric emptying of a solid meal and emptying of the gallbladder before and after vagotomy[J]. Gut, 1987, 28: 855-863
11 Moreno-Osset E, Tomas-Ridocci M, Paris F, et al. Motor activity of esophageal substitute (stomach, jejunal and colon segments)[J]. Ann Thorac Surg, 1986, 41: 515
12苏济豪,韩景芳.食管癌及贲门癌术后胃肠道功能的X线研究[J].肿瘤防治研究, 1978, 1(1): 9
13 Sheiner HJ. Gastric emptying tests in man[J]. Gut, 1975, 16: 235
14 Lam KH, Lim ST, Wong J, et al. Gastric histology and fuction in patients with intrathoracic stomach replacement after esophagectomy[J]. Surgery, 1979, 85(3): 283
15 Code CF, Hightower NC, Morlock CG. Motility of the alimentary canal in man[J]. Am J Med, 1954, 13: 328
16 Miller H, Lam KH, ong GB. observation of pressure waves in stomach, jejunal and colonic loops used to replace the esophagus[J]. Surgery, 1975, 78: 545
17张德超.食管癌切除术附加与不附加幽门成型术的对比研究[J].中华外科杂志, 1983, 21 (8): 455
18戴家训,张进华.食管癌手术后器官机能变化[J].中国肿瘤临床, 1997, 18(增): 305
19 Masahiro N. Functioning of the intrathoracic stomach after esophagectomy[J]. Arch Surg, 1994, 129(8): 837.
20王其彰,张长保,王起民.食管癌切除术后胃排空[J].中华肿瘤杂志, 1988, 4(4): 301
21王其彰,张长保,李保庆.食管癌切除术后双相胃排空[J].中华胸心血管外科杂志, 1999, 15(6): 335
22刘俊峰,王金栋,张少为,等.食管癌与贲门癌患者术后残余食管与胸腔胃功能的研究[J].中华医学杂志, 2005, 85(38): 2678-2681
23王其彰,张毓德,杜喜群.食管癌切除术后重建食管的测压观察[J].中华外科杂志, 1988, 26(5): 305-307
24赵雍凡,王资斌,蒋光亮.切除食管癌两种消化道重建方式后胃食管返流的研究[J].中华胸心血管外科杂志, 1999, 15(3): 135
25 Aylwyn M, Hinder RA, San-Garde BA. The thoracic stomach: a study of gastric emptying bile reflux and mucosal changer[J]. Br J Surg, 1984, 71(6): 438
26 Hinder RA. The effect of posture on the emptying of the intrathoracic vagotomized stomach[J]. Br J Surg, 1976, 63:581
27 Wilbur BG, Kelly KA. Effect of proximal gastric, complete gastric and truncal vagotomy on canine gastric electric activity, motility and emptying[J]. Ann Surg, 1973, 178: 295-303
28 Tomomasa T, Kurome T, Arai H, et al. Erythromycin induces migrating motor complex in human gastrointestinal tract[J]. Dig Dis Sci, 1986, 31: 157-161
29 Depootere I, Peeters TL, Matthijs G, Vantrappen G. Macrolide antibiotics are motilin receptor agonists[J]. Hepato-Gastroenterology, 1988, 35: 198
30 Kondo Y, Torri K, Omura S, Itoh Z. Erythromycin and its derivatives with motilin-like biological activities inhibit the specific binding of 125I-motilin to duodenal muscle[J]. Biochem Biophys Res Commun, 1988, 150(2): 877-882
31 Peeters T, Matthijs G, Depoortere T, et al. Erythromycin is a motilin receptor agonist[J] Am J Physiol, 1989, 257: 470-474
32 Catnach SM, Fairelough PD. Erythromycin and the gut[J]. Gut, 1992, 37: 397-401
33 FIORUCCI S. Effect of erythromycin on gallbladder emptying in diabetic patients with and without autonomic neuropathy and high levels of motilin[J]. Dig Dis Sci, 1992, 37(11): 1671-1677
34 Baker RA, Saccone GTP, Toouli J. Cisapride inhibits motility of the sphincter of Oddi in the Australian possum[J].Dig Dis Sci, 1990, 35: 711-715
35 Fiorucci S, Bosso R, Morelli A. Erythromycin stimulates gallbladder emptying and motilin release by atropinesensitive pathways[J]. Dig Dis Sci, 1992, 37: 1678-1684
36 Otterson MF, Sarna SK. Gastrointestinal motor effects of erythromycin[J]. Am J Physiol, 1990, 259(22): G355-363
37 Mannell A, Hinder RH, San-Garde BH, et al. The thoracic stomach: a study of gastric emptying, bile reflux and mucosal change[J]. Br J Surg, 1984, 71(6): 438
38陈伟锋,陈正煊,许东奎.食管癌切除术残余食管及胸胃的动力学研究[J].中山医科大学学报, 1999, 20(2): 155-157
39刘成军,刘俊峰,王海顺.小剂量红霉素对食管癌和贲门癌患者术后胃电图的影响[J].食管外科, 2008, 7(2):65-72
40 Michael Burt, Andrew Scott, William C Williard, et al. Erythromycin stimilates gastric emptying after esophagectomy with gastric replacement a randomized clinical trial[J]. J Thorac Cardiouasc Surg, 1996, 111: 6491
41 Christian A Gutschow, Jean Marie Collard, Renato Romagnoli, et al. Bile exposure of the denervated stomach as an esophageal substitute[J]. Ann Thorac Surg, 2001, 71: 17861
42秦亚东,支立才,韩振朝.食管贲门癌术后胃代食管重建的测压研究[J].中国肿瘤临床, 1992, 19(4): 248-249
43 Katayama K, Morio Y, Haga K, et al. Cisapride, agastroprokinetic agent, binds to 5-HT4 receptors[J]. Nippon Yakurigaku Zasshi, 1995, 105 (6): 461-468
44 Yoshida N, Ito T, Karasawa T, et al. As-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs[J]. J Pharmacol Exp ther, 1991, 257(2): 781-787
45 Mine Y. Yoshikawa T, Oku S, et al. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro[J]. J Pharmacol Exp Ther, 1997, 283(3): 1000-1008
46 Carlsson L, Amos GJ, Andersson B. Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential[J]. J Pharmacol Exp Ther, 1997, 282(1): 220-227
47 Kii Y, Ito T. Effects of 5-HT4 receptor agonists, cisapride, mosapride citrate, and zacopride on cardiac actionpotentials on guinea pig isolated papillary muscles[J]. J Cardiovasc Pharmacol, 1997, 29(5): 670-675
48金华,张铁军.枸橼酸莫沙比利——新型胃动力药[J].药学进展, 2000, 24(5): 307-308
49申屠阳,周允中.胃肠动力剂对术后胸腔胃状态的影响[J].中国胸心血管外科临床杂志, 2000, 7(1): 18-20
50张正斌.莫沙比利治疗食管癌与贲门癌术后胃排空障碍[J].现代中西医结合杂志, 2007, 16(29): 4422
2刘琳,唐谨,王永岗,等.颈、胸段食管癌术后的核素胃排空检查.中华核医学杂志, 1994, 14:137-139
3候浚,张国生,刘恬格,等. 1990～1992河北省21县癌症死亡率分析[J].河北医药, 1995, 17(5): 20-38
4 Holle GE, Hahn D, Forth W. Innervation of pylorus in control of motility and gastric emptying[J]. Am J physiol, 1992, 263(25): 161-168
5 Grider J, River J. Vasoactive intestinal polypeptide(VIP) as transmitter of inhibitory motor neurons of the gut: Evidence from the use of selective VIP antiserem[J]. J Pharmacol Exp Ther, 1990, 253(2): 738-742
6 Hinton J, Lennard J, Yong A. A new method for studying gut transit time using radiopaque markers[J], Gut, 1967, 10:842-847
7陈延,王学勤,戴菲,等.不透X线标记物检测胃肠道运动的临床应用[J].实用放射学杂志, 2001, 17(9): 647-650
8王其彰,王如然,马立敏,等.显示子用于检查食管癌切除术后胃排空[J].中华外科杂志, 2000, 38(7): 529-530
9王永岗,张汝刚,张大为,等.食管癌术后胸胃功能的研究[J].中华肿瘤杂志, 1997, 19(5): 385-388
10王其彰,王起民,张长保,等.食管癌切除术后胃排空[J].中华肿瘤杂志, 1988, 10(4): 301-303
11刘俊峰,王金栋,张少为,等.食管癌与贲门癌患者术后残余食管与胸腔胃功能的研究[J].中华医学杂志, 2005, 85(38): 2678-2681
12王士杰,王其彰,主编.食管癌与贲门癌[M].北京:人民卫生出版社, 2008: 252
13王其彰,张长保,李保庆,等.食管癌切除术后双相胃排空[J].中华胸心血管外科杂志, 1999, 15(6): 335-336
14 Kelly KA. Gastric emptying disorders following gastric surgery. In: Dubois A, Castell DO, eds. Esophageal and gastric emptying[M]. Boca Raton: CRC Press, 1984: 89-94
15 Mannell A, Hinder RH, San-Garde BH, et al. The thoracic stomach: a study of gastric emptying, bile reflux and mucosal change[J]. Br J Surg, 1984, 71(6): 438-441
16陈新谦,金有豫,汤光.新编药物学[M].第16版.北京:人民卫生出版社, 2007: 486
17 Katayama K, Morio Y, Haga K, et al. Cisapride, a gastroprokinetic agent, binds to 5-HT4 receptors[J]. NipponYakurigaku Zasshi, 1995, 105(6): 461-468
18 Mine Y. Yoshikawa T, Oku S, et al. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro[J]. J Pharmacol Exp Ther, 1997, 283(3): 1000-1008
19 Kii Y, Ito T. Effects of 5-HT4-receptor agonists, cisapride, mosapride citrate, and zacopride on cardiac action potentials on guinea pig isolated papillary muscles[J]. J Cardiovasc Pharmacol, 1997, 29(5): 670-675
20金华,张铁军.枸橼酸莫沙比利-新型胃动力药[J].药学进展, 2000, 24(5): 307-308
21 Yoshida N, Ito T, Karasawa T, et al. As-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs[J]. J Pharmacol Exp ther, 1991, 257(2): 781-787
22申屠阳,周允中.胃肠动力剂对术后胸腔胃状态的影响[J].中国胸心血管外科临床杂志, 2000, 7(1): 18-20
23张正斌.莫沙比利治疗食管癌与贲门癌术后胃排空障碍[J].现代中西医结合杂志, 2007, 16(29): 4422
1潘国宗,曹世植,主编.现代胃肠病学[M].北京:科学出版社, 1994: 1352
2王永岗,张汝刚,张大为,等.食管癌术后胸胃功能的研究[J].中华肿瘤杂志, 1997, 19(5): 385-388
3王其彰,王起民,张长保,等.食管癌切除术后胃排空[J].中华肿瘤杂志, 1988, 10(4): 301-303
4刘俊峰,王金栋,张少为,等.食管癌与贲门癌患者术后残余食管与胸腔胃功能的研究[J].中华医学杂志, 2005, 85(38): 2678-2681
5刘琳,唐谨,王永岗,等.颈、胸段食管癌术后的核素胃排空检查[J].中华核医学杂志, 1994, 14(3), 137-139
6 Minaml H, Mccallum RW. The physiology and Pathophysiology of gastric emptying in humans[J].Gastroenterology, 1984, 86(6): 1592-1610
7 Deleyn P, Coosemans W, Lerut. Early and late functional results in patients with intrathoracic gastric replacement after esophagectomy for carcinoma[J]. Eur J Cardiothorac Surg, 1992, 6(2): 79-84
8 Masahiro N. Functioning of the intrathoracic stomach after esophagectomy[J]. Arch Surg, 1994, 129(8): 837
9 Calabuig R, Carrio I, Mones J, et al. Gastric and emptying after truncal vagotomy and pyloroplasty[J]. Scand J Gast roenterol, 1988, 23(6): 659-664
10 Baxter JN, Grime J S, Critchley M, et al. Relationship between gastric emptying of a solid meal and emptying of the gallbladder before and after vagotomy[J]. Gut, 1987, 28: 855-863
11 Moreno-Osset E, Tomas-Ridocci M, Paris F, et al. Motor activity of esophageal substitute (stomach, jejunal and colon segments)[J]. Ann Thorac Surg, 1986, 41: 515
12苏济豪,韩景芳.食管癌及贲门癌术后胃肠道功能的X线研究[J].肿瘤防治研究, 1978, 1(1): 9
13 Sheiner HJ. Gastric emptying tests in man[J]. Gut, 1975, 16: 235
14 Lam KH, Lim ST, Wong J, et al. Gastric histology and fuction in patients with intrathoracic stomach replacement after esophagectomy[J]. Surgery, 1979, 85(3): 283
15 Code CF, Hightower NC, Morlock CG. Motility of the alimentary canal in man[J]. Am J Med, 1954, 13: 328
16 Miller H, Lam KH, ong GB. observation of pressure waves in stomach, jejunal and colonic loops used to replace the esophagus[J]. Surgery, 1975, 78: 545
17张德超.食管癌切除术附加与不附加幽门成型术的对比研究[J].中华外科杂志, 1983, 21 (8): 455
18戴家训,张进华.食管癌手术后器官机能变化[J].中国肿瘤临床, 1997, 18(增): 305
19 Masahiro N. Functioning of the intrathoracic stomach after esophagectomy[J]. Arch Surg, 1994, 129(8): 837.
20王其彰,张长保,王起民.食管癌切除术后胃排空[J].中华肿瘤杂志, 1988, 4(4): 301
21王其彰,张长保,李保庆.食管癌切除术后双相胃排空[J].中华胸心血管外科杂志, 1999, 15(6): 335
22刘俊峰,王金栋,张少为,等.食管癌与贲门癌患者术后残余食管与胸腔胃功能的研究[J].中华医学杂志, 2005, 85(38): 2678-2681
23王其彰,张毓德,杜喜群.食管癌切除术后重建食管的测压观察[J].中华外科杂志, 1988, 26(5): 305-307
24赵雍凡,王资斌,蒋光亮.切除食管癌两种消化道重建方式后胃食管返流的研究[J].中华胸心血管外科杂志, 1999, 15(3): 135
25 Aylwyn M, Hinder RA, San-Garde BA. The thoracic stomach: a study of gastric emptying bile reflux and mucosal changer[J]. Br J Surg, 1984, 71(6): 438
26 Hinder RA. The effect of posture on the emptying of the intrathoracic vagotomized stomach[J]. Br J Surg, 1976, 63:581
27 Wilbur BG, Kelly KA. Effect of proximal gastric, complete gastric and truncal vagotomy on canine gastric electric activity, motility and emptying[J]. Ann Surg, 1973, 178: 295-303
28 Tomomasa T, Kurome T, Arai H, et al. Erythromycin induces migrating motor complex in human gastrointestinal tract[J]. Dig Dis Sci, 1986, 31: 157-161
29 Depootere I, Peeters TL, Matthijs G, Vantrappen G. Macrolide antibiotics are motilin receptor agonists[J]. Hepato-Gastroenterology, 1988, 35: 198
30 Kondo Y, Torri K, Omura S, Itoh Z. Erythromycin and its derivatives with motilin-like biological activities inhibit the specific binding of 125I-motilin to duodenal muscle[J]. Biochem Biophys Res Commun, 1988, 150(2): 877-882
31 Peeters T, Matthijs G, Depoortere T, et al. Erythromycin is a motilin receptor agonist[J] Am J Physiol, 1989, 257: 470-474
32 Catnach SM, Fairelough PD. Erythromycin and the gut[J]. Gut, 1992, 37: 397-401
33 FIORUCCI S. Effect of erythromycin on gallbladder emptying in diabetic patients with and without autonomic neuropathy and high levels of motilin[J]. Dig Dis Sci, 1992, 37(11): 1671-1677
34 Baker RA, Saccone GTP, Toouli J. Cisapride inhibits motility of the sphincter of Oddi in the Australian possum[J].Dig Dis Sci, 1990, 35: 711-715
35 Fiorucci S, Bosso R, Morelli A. Erythromycin stimulates gallbladder emptying and motilin release by atropinesensitive pathways[J]. Dig Dis Sci, 1992, 37: 1678-1684
36 Otterson MF, Sarna SK. Gastrointestinal motor effects of erythromycin[J]. Am J Physiol, 1990, 259(22): G355-363
37 Mannell A, Hinder RH, San-Garde BH, et al. The thoracic stomach: a study of gastric emptying, bile reflux and mucosal change[J]. Br J Surg, 1984, 71(6): 438
38陈伟锋,陈正煊,许东奎.食管癌切除术残余食管及胸胃的动力学研究[J].中山医科大学学报, 1999, 20(2): 155-157
39刘成军,刘俊峰,王海顺.小剂量红霉素对食管癌和贲门癌患者术后胃电图的影响[J].食管外科, 2008, 7(2):65-72
40 Michael Burt, Andrew Scott, William C Williard, et al. Erythromycin stimilates gastric emptying after esophagectomy with gastric replacement a randomized clinical trial[J]. J Thorac Cardiouasc Surg, 1996, 111: 6491
41 Christian A Gutschow, Jean Marie Collard, Renato Romagnoli, et al. Bile exposure of the denervated stomach as an esophageal substitute[J]. Ann Thorac Surg, 2001, 71: 17861
42秦亚东,支立才,韩振朝.食管贲门癌术后胃代食管重建的测压研究[J].中国肿瘤临床, 1992, 19(4): 248-249
43 Katayama K, Morio Y, Haga K, et al. Cisapride, agastroprokinetic agent, binds to 5-HT4 receptors[J]. Nippon Yakurigaku Zasshi, 1995, 105 (6): 461-468
44 Yoshida N, Ito T, Karasawa T, et al. As-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs[J]. J Pharmacol Exp ther, 1991, 257(2): 781-787
45 Mine Y. Yoshikawa T, Oku S, et al. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro[J]. J Pharmacol Exp Ther, 1997, 283(3): 1000-1008
46 Carlsson L, Amos GJ, Andersson B. Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential[J]. J Pharmacol Exp Ther, 1997, 282(1): 220-227
47 Kii Y, Ito T. Effects of 5-HT4 receptor agonists, cisapride, mosapride citrate, and zacopride on cardiac actionpotentials on guinea pig isolated papillary muscles[J]. J Cardiovasc Pharmacol, 1997, 29(5): 670-675
48金华,张铁军.枸橼酸莫沙比利——新型胃动力药[J].药学进展, 2000, 24(5): 307-308
49申屠阳,周允中.胃肠动力剂对术后胸腔胃状态的影响[J].中国胸心血管外科临床杂志, 2000, 7(1): 18-20
50张正斌.莫沙比利治疗食管癌与贲门癌术后胃排空障碍[J].现代中西医结合杂志, 2007, 16(29): 4422