全麻药对脑功能影响的影像学研究
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摘要
本实验应用多种脑功能成像技术，研究全身麻醉药对脑局部葡萄糖代谢、脑信号强度及相关脑区内神经递质的变化，以探讨全麻药敏感的靶位及可能机制，为进一步阐明全身麻醉的机理提供理论依据。
第一部分 应用PET技术研究全麻药对健康志愿者脑能量代谢的影响
目的：应用PET成像技术，研究全麻药七氟醚、氯胺酮对人脑能量代谢的影响，探讨全麻药作用的敏感脑区，为进一步阐明全麻机理提供理论依据。方法：七氟醚组每位志愿者分别做三次PET扫描，采用PHILIPS CPET Plus扫描仪及~(18)F-FDG标记技术测定CMRglu，第一次在清醒状态下扫描作为对照，第二、三次分别吸入0.5MAC和1.0MAC浓度七氟醚。氯胺酮组每位志愿者分别在氯胺酮血浆药物浓度为0.2ug／ml(镇静状态)和1.1ug／ml(意识消失)时注射~(18)F-FDG显像剂，并进行PET扫描。结果：①
With the application of varied cerebral function imaging technologies, the study investigated the effect of general anesthesia medicine on the glycometabolism, signal intensity and neurotransmitter metabolism in the CNS, in order to approach the sensitive target sites of general anesthesia medicine and the possible mechanisms, which might provide theoretical basis for the mechanism of general anesthesia.
Part I Effects of the General Anesthesia Medicine on the Energy Metabolism of the Healthy Volunteers ' Brains by PET
Objective: With the positron emission tomography technology, to study the changes in the cerebral energy metabolism produced by sevoflurane or ketamine, to determine the sensitive regions to the general anesthesia medicine, and to provide theoretical basis for the mechanism of general anesthesia. Methods: Volunteers in the sevoflurane groups underwent PET scans for
第一部分 应用PET技术研究全麻药对健康志愿者脑能量代谢的影响
目的：应用PET成像技术，研究全麻药七氟醚、氯胺酮对人脑能量代谢的影响，探讨全麻药作用的敏感脑区，为进一步阐明全麻机理提供理论依据。方法：七氟醚组每位志愿者分别做三次PET扫描，采用PHILIPS CPET Plus扫描仪及~(18)F-FDG标记技术测定CMRglu，第一次在清醒状态下扫描作为对照，第二、三次分别吸入0.5MAC和1.0MAC浓度七氟醚。氯胺酮组每位志愿者分别在氯胺酮血浆药物浓度为0.2ug／ml(镇静状态)和1.1ug／ml(意识消失)时注射~(18)F-FDG显像剂，并进行PET扫描。结果：①
With the application of varied cerebral function imaging technologies, the study investigated the effect of general anesthesia medicine on the glycometabolism, signal intensity and neurotransmitter metabolism in the CNS, in order to approach the sensitive target sites of general anesthesia medicine and the possible mechanisms, which might provide theoretical basis for the mechanism of general anesthesia.
Part I Effects of the General Anesthesia Medicine on the Energy Metabolism of the Healthy Volunteers ' Brains by PET
Objective: With the positron emission tomography technology, to study the changes in the cerebral energy metabolism produced by sevoflurane or ketamine, to determine the sensitive regions to the general anesthesia medicine, and to provide theoretical basis for the mechanism of general anesthesia. Methods: Volunteers in the sevoflurane groups underwent PET scans for
引文
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