中医推拿综合测定系统的若干关键技术研究
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摘要
推拿疗法是临床上一种重要的非药物治疗方法,对诸多疾病都有显著的疗效。它是医生在中医基本理论指导下,通过手法在患者体表操作,以物理的力学刺激调节机体生理、病理状况,以达到舒经通络、活血化瘀、舒筋散结、蠲邪扶正的治疗目的。目前国内外均未见到有可在实际治疗时综合测定和分析中医推拿作用的仪器设备,使得很难全面客观的反映临床上推拿操作及其产生的生物学效应,严重阻碍了对推拿机理的研究和推拿疗法的进一步发展。
本文在国家高技术研究发展计划资助项目“用于检测三维力的人工皮肤,,(NO.2007AA042220)以及国家自然科学基金面上项目“基于新型压力温度敏感导电橡胶的多功能阵列触觉传感器研究”(No.61072032)和“一种新型柔性多维阵列触觉传感器的研究”(NO.60672024)的支持下,针对目前推拿机理研究遇到的难题,综合应用中医推拿理论、材料科学、接触力学、传感技术等多学科的理论和技术,提出了一种基于整体生物学效应的推拿机理测试分析方法,设计了一台可在临床推拿过程中实时检测推拿力、同时监测被推拿者相关人体生理学参数的综合测定系统,打破了在推拿临床过程中缺乏可以量化推拿手法操作以及检测人体相关生理学参数的仪器的研究现状：对所提出的推拿机理研究思路的可行性、推拿力与被推拿者相关表面肌电信号之间的关联性、可用作力学量综合测定垫的传感器结构、物理模型以及解耦等关键问题进行了分析和研究。
本文的主要研究内容及取得的创新性成果如下：
1.针对当前中医推拿机理研究存在的难题,将中医学与现代医学理论相结合,提出了一种基于人体整体生物学效应的推拿机理研究方法,并搭建了推拿机理测试分析研究的框架；设计了一种中医推拿综合测定系统,该仪器由检测系统和分析系统两部分组成,可在临床推拿过程中实时检测医生的推拿手法力信息,并实时监测被推拿者相关的生理学参数,有望为推拿机理的研究提供测试分析平台。
2.以指按法推拿与被推拿者表面肌电信号的关联性为例对推拿产生的生物学效应进行了初步探讨。设计了一种可在推拿过程中实时检测指按法作用力与受试者相关部位表面肌电信号的多信息采集系统,通过该系统采集了推拿过程中的指按法作用力信息以及受试者相应的sEMG信号,并针对推拿作用的特点对采集的数据进行分析,分析结果表明推拿力对人体肌肉电生理活动有明显的即时影响。
3.从压敏导电橡胶的理想特性出发,得到了三维力柔性阵列传感器的三维力-电阻整体模型,采用基于LM算法的解耦方法进行了仿真,为三维力柔性阵列传感器的结构设计及力学特征的提取提供了理论依据。
4.根据推拿作用力的检测需求,提出了一种新的基于导电橡胶的三维力柔性阵列传感器结构,使其具有更好的柔弹性和更薄的厚度：在线电阻模型的基础上结合导电橡胶的部分实际性质建立了传感器的三维力-电阻简化模型,并通过对该模型的求解初步解决了传感器受力时的耦合问题,初步满足了推拿力检测对传感器性能参数的要求。
5.基于导电橡胶的实际受力情况和传感器的内部构造,深入分析了传感器受三维力时的电阻应变关系,弱化以往建模的诸多假设条件,对上述三维力-电阻简化模型作了较大的修正,建立了更符合实际特性的传感器表面三维力激励与输出电阻的物理模型,进一步揭示了传感器的传感机理；在传感器输入输出特性的仿真结果基础上对传感器结构进行了优化,并初步解决了传感器受力时复杂的耦合现象。该模型的提出更多的考虑到传感器的实际情况,为进一步研究适用于推拿力信息检测的力学量综合测定垫提供了理论基础。
Massage is an important kind of non-drug treatments and has notable curative effect on many diseases. It is a therapy that doctor operates on the patient by manipulation, with mechanical stimulations to regulate the body's physiology and pathology, ultimately achieve the effects of dredging meridian, activating blood and resolving blood-stasis, relaxing muscles and tendons, eliminating pathogens and strengthening vital qi. So far there is no such kind of equipments capable to measure and analyze the effectiveness of massage, which result in the fact that it is difficult to reflect operations of massage and the related biological effect comprehensively and objectively, and it has seriously hindered the development of the research of the mechanism of traditional Chinese medical massage.
This dissertation is originated from the National Natural Science Foundation (NO.60672024, NO.61072032) and National High Technology Research and Development Program (863Program NO.2007AA042220). Considering the lack of a platform which can detect the3D forces applied by massage doctors and the correlative physiological parameters detected by the treated area of human body in real-time, this dissertation presents a measuring and analysis method based on holistic biological effect, makes an innovative research on the key problems, such as the correlation between massage operations and biological effect, physical model of the sensor, and decouple of the sensor, etc. And on this basis, develops a measuring and analyzing platform which can detect the3D forces applied by massage doctors in real-time, and synchronously, monitor and record the correlative physiological parameters detected by the treated area of human body.
The major study context and innovative results are as follows:
1. Aimed at solving the mechanism of traditional Chinese medical massage, a measuring and analysis method based on holistic biological effect is presented by combining Chinese medicine and modern medical theory. A measuring and analyzing platform which consist of two parts, detecting system and analyzing system, is developed that can detect the3D forces applied by massage doctors in real-time, and synchronously, monitor and record the correlative physiological parameters detected by the treated area of human body, lay a foundation for the development of massage mechanism.
2. Explores the correlation between massage operations and sEMG. Multi-information sampling system which can detect the force of finger-pressing manipulation and sEMG signals of the sample involved in real time is built. The force and sEMG signals collected by the system are analyzed based on the characteristics of massage operations, and the results indicates that there is a remarkable effect on sEMG by finger-pressing manipulation.
3. Based on the ideal characteristics of pressure-sensitive conductive rubber, the overall physical model of the3-D force flexible array sensor is proposed, and applied a decoupling method based on LM algorithm to simulate. This analysis results can provide theoretical basis for the structure design and force information extraction of3-D flexible array sensor based on conductive rubber.
4. According to the massage forces detecting requirements, a new kind of3-D force flexible array sensor is developed, which is thinner and more flexible. And a simplified model of the sensor is established combined with part of the sensitive material's actual characteristics, and the complicated coupling problems are solved by the model, and can further satisfy the demands to the massage forces detecting.
5. Based on the conductive rubber's actual force conditions and the sensor's internal structure, the relationship between the resistance and strain of conductive rubber is analyzed in depth, then weakening the hypothesis in the past research, revising the simplified model, and a physical model of a3D force excitation and output resistances of the sensor is employed, by which the sensing mechanism of the3D flexible tactile sensor array based on pressure-sensitive conductive rubber is explored in more detail. The structure of the sensor is optimized according to the simulation results. More operational factors based on the sensitive material's actual characteristics are taken into account in the model, which can provided theory support for the development of the mechanical quantities comprehensive detection cushion for the massage acting forces measurement.
本文在国家高技术研究发展计划资助项目“用于检测三维力的人工皮肤,,(NO.2007AA042220)以及国家自然科学基金面上项目“基于新型压力温度敏感导电橡胶的多功能阵列触觉传感器研究”(No.61072032)和“一种新型柔性多维阵列触觉传感器的研究”(NO.60672024)的支持下,针对目前推拿机理研究遇到的难题,综合应用中医推拿理论、材料科学、接触力学、传感技术等多学科的理论和技术,提出了一种基于整体生物学效应的推拿机理测试分析方法,设计了一台可在临床推拿过程中实时检测推拿力、同时监测被推拿者相关人体生理学参数的综合测定系统,打破了在推拿临床过程中缺乏可以量化推拿手法操作以及检测人体相关生理学参数的仪器的研究现状：对所提出的推拿机理研究思路的可行性、推拿力与被推拿者相关表面肌电信号之间的关联性、可用作力学量综合测定垫的传感器结构、物理模型以及解耦等关键问题进行了分析和研究。
本文的主要研究内容及取得的创新性成果如下：
1.针对当前中医推拿机理研究存在的难题,将中医学与现代医学理论相结合,提出了一种基于人体整体生物学效应的推拿机理研究方法,并搭建了推拿机理测试分析研究的框架；设计了一种中医推拿综合测定系统,该仪器由检测系统和分析系统两部分组成,可在临床推拿过程中实时检测医生的推拿手法力信息,并实时监测被推拿者相关的生理学参数,有望为推拿机理的研究提供测试分析平台。
2.以指按法推拿与被推拿者表面肌电信号的关联性为例对推拿产生的生物学效应进行了初步探讨。设计了一种可在推拿过程中实时检测指按法作用力与受试者相关部位表面肌电信号的多信息采集系统,通过该系统采集了推拿过程中的指按法作用力信息以及受试者相应的sEMG信号,并针对推拿作用的特点对采集的数据进行分析,分析结果表明推拿力对人体肌肉电生理活动有明显的即时影响。
3.从压敏导电橡胶的理想特性出发,得到了三维力柔性阵列传感器的三维力-电阻整体模型,采用基于LM算法的解耦方法进行了仿真,为三维力柔性阵列传感器的结构设计及力学特征的提取提供了理论依据。
4.根据推拿作用力的检测需求,提出了一种新的基于导电橡胶的三维力柔性阵列传感器结构,使其具有更好的柔弹性和更薄的厚度：在线电阻模型的基础上结合导电橡胶的部分实际性质建立了传感器的三维力-电阻简化模型,并通过对该模型的求解初步解决了传感器受力时的耦合问题,初步满足了推拿力检测对传感器性能参数的要求。
5.基于导电橡胶的实际受力情况和传感器的内部构造,深入分析了传感器受三维力时的电阻应变关系,弱化以往建模的诸多假设条件,对上述三维力-电阻简化模型作了较大的修正,建立了更符合实际特性的传感器表面三维力激励与输出电阻的物理模型,进一步揭示了传感器的传感机理；在传感器输入输出特性的仿真结果基础上对传感器结构进行了优化,并初步解决了传感器受力时复杂的耦合现象。该模型的提出更多的考虑到传感器的实际情况,为进一步研究适用于推拿力信息检测的力学量综合测定垫提供了理论基础。
Massage is an important kind of non-drug treatments and has notable curative effect on many diseases. It is a therapy that doctor operates on the patient by manipulation, with mechanical stimulations to regulate the body's physiology and pathology, ultimately achieve the effects of dredging meridian, activating blood and resolving blood-stasis, relaxing muscles and tendons, eliminating pathogens and strengthening vital qi. So far there is no such kind of equipments capable to measure and analyze the effectiveness of massage, which result in the fact that it is difficult to reflect operations of massage and the related biological effect comprehensively and objectively, and it has seriously hindered the development of the research of the mechanism of traditional Chinese medical massage.
This dissertation is originated from the National Natural Science Foundation (NO.60672024, NO.61072032) and National High Technology Research and Development Program (863Program NO.2007AA042220). Considering the lack of a platform which can detect the3D forces applied by massage doctors and the correlative physiological parameters detected by the treated area of human body in real-time, this dissertation presents a measuring and analysis method based on holistic biological effect, makes an innovative research on the key problems, such as the correlation between massage operations and biological effect, physical model of the sensor, and decouple of the sensor, etc. And on this basis, develops a measuring and analyzing platform which can detect the3D forces applied by massage doctors in real-time, and synchronously, monitor and record the correlative physiological parameters detected by the treated area of human body.
The major study context and innovative results are as follows:
1. Aimed at solving the mechanism of traditional Chinese medical massage, a measuring and analysis method based on holistic biological effect is presented by combining Chinese medicine and modern medical theory. A measuring and analyzing platform which consist of two parts, detecting system and analyzing system, is developed that can detect the3D forces applied by massage doctors in real-time, and synchronously, monitor and record the correlative physiological parameters detected by the treated area of human body, lay a foundation for the development of massage mechanism.
2. Explores the correlation between massage operations and sEMG. Multi-information sampling system which can detect the force of finger-pressing manipulation and sEMG signals of the sample involved in real time is built. The force and sEMG signals collected by the system are analyzed based on the characteristics of massage operations, and the results indicates that there is a remarkable effect on sEMG by finger-pressing manipulation.
3. Based on the ideal characteristics of pressure-sensitive conductive rubber, the overall physical model of the3-D force flexible array sensor is proposed, and applied a decoupling method based on LM algorithm to simulate. This analysis results can provide theoretical basis for the structure design and force information extraction of3-D flexible array sensor based on conductive rubber.
4. According to the massage forces detecting requirements, a new kind of3-D force flexible array sensor is developed, which is thinner and more flexible. And a simplified model of the sensor is established combined with part of the sensitive material's actual characteristics, and the complicated coupling problems are solved by the model, and can further satisfy the demands to the massage forces detecting.
5. Based on the conductive rubber's actual force conditions and the sensor's internal structure, the relationship between the resistance and strain of conductive rubber is analyzed in depth, then weakening the hypothesis in the past research, revising the simplified model, and a physical model of a3D force excitation and output resistances of the sensor is employed, by which the sensing mechanism of the3D flexible tactile sensor array based on pressure-sensitive conductive rubber is explored in more detail. The structure of the sensor is optimized according to the simulation results. More operational factors based on the sensitive material's actual characteristics are taken into account in the model, which can provided theory support for the development of the mechanical quantities comprehensive detection cushion for the massage acting forces measurement.
引文
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