溃结灌肠液与柳氮磺吡啶栓治疗溃疡性直肠炎的临床对比研究
|
摘要
目的：探讨直肠给药这类外治疗法治疗溃疡性直肠炎的临床疗效及应用优势,并将溃结灌肠液灌肠与柳氮磺吡啶栓纳肛这两种不同的直肠给药方法治疗溃疡性直肠炎的疗效做对比研究。
方法：筛选并收录符合纳入标准的溃疡性直肠炎患者共30例,将患者随机分成两组,即灌肠组(实验组15例)和纳肛组(对照组15例),两组患者在年龄、性别方面的差异无统计学意义(P<0.05)。实验组给予溃结灌肠液保留灌肠治疗,每次取温热的溃结灌肠液80m1,用注射器推注保留灌肠,每晚睡前一次；对照组给予柳氮磺吡啶栓纳肛治疗,0.5克/枚,每次一枚,每日2次,午、晚睡前使用,两组患者均连续用药两周作为一个疗程,共3个疗程,观察并如实记录两组患者用药前后的临床表现、症状体征、血常规、粪常规、血沉、C-反应蛋白、肠镜检查等变化,判断疗效及有无不良反应。
结果：两组患者在性别、年龄、病程方面无统计学差异(P>0.05),治疗前后各项观察指标的比较有统计学意义(P<0.05),而治疗后两组患者在大便次数、Sourtherland DAI评分、有效率方面的差异有统计学意义(P<0.05),治疗后两组患者在C-反应蛋白、血沉、内镜Baron评分方面无统计学差异(P>0.05)。结论：溃疡性直肠炎患者具有一定年龄分布规律,患者多集中在35-45岁年龄段；溃结灌肠液灌肠法较柳氮磺吡啶栓纳肛法在治疗溃疡性直肠炎方面的疗效更加显著,为临床治疗溃疡性直肠炎提供了一种疗效好、治愈率高的方法。意义：为临床合理用药提供参考。
Objective:to study the clinical effectiveness and application advantages of the external therapy which be using treating ulcerative proctopathy by rectal administating, and contrast the clinical effectiveness of Ulcerative Colitis enema and Sulfasalazine suppository for treating ulcerative proctopathy.
Methods:screening and included met inclusion criteria of ulcerative proctopathy patients30cases, than randomly divided those patients into two groups—enema group (the15cases) and anus group (the15cases), two groups of patients have no statistically significant differences in age and gender (P<0.05). Given the kuijieguanchang fluid retention enema treatment, filling80ml the fluid with syringe push note every time before sleeping; The control group give liu nitrogen pyridine anus sulfonylurea bolt treatment,0.5g/pieces, one piece a time, twice a day,take it late afternoon and before sleeping, two groups of patients were2weeks for use as a treatment, after three treatment, observe and faithfully record the clinical manifestation, symptoms and signs, routine blood, dung routine, blood sedimentation, c-reactive protein, endoscopic change of two groups of patients before and after treating, judge the effect and adverse reactions.
Results:two groups of patients in the gender, age, duration without statistics difference (P≥0.05), the outcomes show statistically significant after treatment (P<0.05), and frequency of defecate, Sourtherland DAI scoreafter and the efficiency about the patients in two group have significant difference (P<0.05), the c-reactive protein, blood sedimentation, endoscopic Baron scoring have no statistical difference in the patients of two groups after treatment (P>0.05).
Conclusion:ulcerative proctopathy patients have a certain age distribution, patients often focus on35-45years of age; kuijieguanchang fluid enema irrigation method is better than liu nitrogen pyridine anus sulfonylurea bolt method in treating ulcerative colitis straight. It provides a good treatment method for treating ulcerative proctopathy, and the method have the advantage on absorption effect and small side effects.
Meaning:to provide reference for clinical rational drug using.
方法：筛选并收录符合纳入标准的溃疡性直肠炎患者共30例,将患者随机分成两组,即灌肠组(实验组15例)和纳肛组(对照组15例),两组患者在年龄、性别方面的差异无统计学意义(P<0.05)。实验组给予溃结灌肠液保留灌肠治疗,每次取温热的溃结灌肠液80m1,用注射器推注保留灌肠,每晚睡前一次；对照组给予柳氮磺吡啶栓纳肛治疗,0.5克/枚,每次一枚,每日2次,午、晚睡前使用,两组患者均连续用药两周作为一个疗程,共3个疗程,观察并如实记录两组患者用药前后的临床表现、症状体征、血常规、粪常规、血沉、C-反应蛋白、肠镜检查等变化,判断疗效及有无不良反应。
结果：两组患者在性别、年龄、病程方面无统计学差异(P>0.05),治疗前后各项观察指标的比较有统计学意义(P<0.05),而治疗后两组患者在大便次数、Sourtherland DAI评分、有效率方面的差异有统计学意义(P<0.05),治疗后两组患者在C-反应蛋白、血沉、内镜Baron评分方面无统计学差异(P>0.05)。结论：溃疡性直肠炎患者具有一定年龄分布规律,患者多集中在35-45岁年龄段；溃结灌肠液灌肠法较柳氮磺吡啶栓纳肛法在治疗溃疡性直肠炎方面的疗效更加显著,为临床治疗溃疡性直肠炎提供了一种疗效好、治愈率高的方法。意义：为临床合理用药提供参考。
Objective:to study the clinical effectiveness and application advantages of the external therapy which be using treating ulcerative proctopathy by rectal administating, and contrast the clinical effectiveness of Ulcerative Colitis enema and Sulfasalazine suppository for treating ulcerative proctopathy.
Methods:screening and included met inclusion criteria of ulcerative proctopathy patients30cases, than randomly divided those patients into two groups—enema group (the15cases) and anus group (the15cases), two groups of patients have no statistically significant differences in age and gender (P<0.05). Given the kuijieguanchang fluid retention enema treatment, filling80ml the fluid with syringe push note every time before sleeping; The control group give liu nitrogen pyridine anus sulfonylurea bolt treatment,0.5g/pieces, one piece a time, twice a day,take it late afternoon and before sleeping, two groups of patients were2weeks for use as a treatment, after three treatment, observe and faithfully record the clinical manifestation, symptoms and signs, routine blood, dung routine, blood sedimentation, c-reactive protein, endoscopic change of two groups of patients before and after treating, judge the effect and adverse reactions.
Results:two groups of patients in the gender, age, duration without statistics difference (P≥0.05), the outcomes show statistically significant after treatment (P<0.05), and frequency of defecate, Sourtherland DAI scoreafter and the efficiency about the patients in two group have significant difference (P<0.05), the c-reactive protein, blood sedimentation, endoscopic Baron scoring have no statistical difference in the patients of two groups after treatment (P>0.05).
Conclusion:ulcerative proctopathy patients have a certain age distribution, patients often focus on35-45years of age; kuijieguanchang fluid enema irrigation method is better than liu nitrogen pyridine anus sulfonylurea bolt method in treating ulcerative colitis straight. It provides a good treatment method for treating ulcerative proctopathy, and the method have the advantage on absorption effect and small side effects.
Meaning:to provide reference for clinical rational drug using.
引文
[1]曹倩,胡伟玲,高敏,等.379例炎症性肠病临床特征分析[J].中华消化杂志,2005,25(04)
[2]Regueiro MD. Diagnosis and treatment of ulcerative proctitis[J]. Clin Gastroenterol,2004,38:733-740
[3]宇都宫利善.溃疡性大肠炎患者的年龄分布与发病年龄的若年化[R].厚生省特定疾患“难治性炎症性肠管障害”调查研究班.平成3年度研究报告书,1991：181-187
[4]项平,徐富垦,欧平安.溃疡性结肠炎486例结肠镜查的评价和分析[J].中华消化杂志,1996,16：136-138
[5]北洞哲治.炎症性肠疾患的疫学[J].临床杂志内科,1998,82：209-213
[6]Lamet M, Ptak T, Dallaire C, et al. Mesalamine Study Group. Efficacy and safety of mesalamine 1 g HS versus 500 mg BID suppositories in mild to moderate ulcerative proctitis:a multicenter randomized study. Inflamm Bowel Dis,2005,11:625-630
[7]陈锦峰,陈建林,韩宇斌,等.芍药汤合白头翁汤治疗轻中度溃疡性结肠炎(湿热内蕴型)30例疗效观察[J].新中医,2008,40(7)：48
[8]陈亚龙,钟晖.抑肝扶脾法治疗慢性溃疡性结肠炎临床观察[J].四川中医,2008,26(7)：52
[9]张相安.辨证分型治疗溃疡性结肠炎69例[J].医药论坛杂志,2008,29(10)：71
[10]韩远茹.中医治疗溃疡性结肠炎研究纂要[J].实用内科学杂志,2008,22(8)：70
[11]吴东,孙健平,吴军,等.自拟灌肠1号结合中药内服治疗慢性溃疡性结肠炎90例分析[J].现代中西医结合杂志,2007,16：338-339
[12]Kombluth A, SacharDB. Ulcerative colitis practice guidelines in adults(update):American College of Gastroenterology[J]. Practice Parameters Committee.Am Gastroenterol,2004,99:1371-1385
[13]康晓玲.中药灌肠治疗慢性非特异性溃疡性结肠炎60例[J].西北药学杂志,2005,20(3)：130
[14]张茄,曾莉.二黄汤结合穴位埋线治疗溃疡性结肠炎临床研究[J].时珍国医国药,2007,18(9)：2268
[15]郭晓原,龙再菊,吴霞,等.针灸配合中药灌肠治疗溃疡性结肠炎22例疗效观察[J].辽宁中医杂志,2007,34(5)：654
[16]李根丑,彭全利.参苓白术散加味治疗溃疡性结肠炎63例[J].陕西中医,2008,29(1)：51
[17]吴蔚,倪斐琳.改良保留灌肠方法治疗溃疡性结肠炎35例观察[J].实用中医内科杂志,2007,21(4),81
[18]王文文,郑萍.苦参合剂直肠滴入法治疗溃疡性结肠炎28例[J].中医外治杂志,2001,10(1);8
[19]陈雁敏,邹翠芳.改良中药保留灌肠法在溃疡性结肠炎治疗中的应用[J].中医中药,2007,4(14)；87
[20]陈霞.中药直肠点滴治疗慢性溃疡性结肠炎65例疗效观察[J].云南中医药,2003,24(3);12
[21]张杰,曾宇锋,肖斌琼,等.致康胶囊复合液灌肠联合结肠镜局部喷注治疗溃疡性结肠炎志者52例[J].中国中西医结合杂志,2005,25(9)：839
[22]曹健彪,李雅君,张红光,等.128例溃疡性结肠炎的镜资料分析[J].中国内镜杂志,2000,6(1)：21-22
[23]林锡芬,陈金泉,张苏闽。气药灌肠法治疗慢性溃疡性结肠炎36例疗效观察[J].新中医,2003,35(7)：24-25
[24]张苏闽,吴昆岚,丁义江,等.气药灌肠治疗溃疡性结肠炎的临床实验研究(附60例资料分析)[J].东南大学学报,2002,21(4)：310-312
[25]张悦,杨振辉.针刺夹脊穴配合梅花针叩刺治疗溃疡性结肠炎43例[J].中医杂志,2003,44(4)：282-283
[26]年云娜.针刺董氏奇穴合拔罐治疗慢性非特异性溃疡性结肠炎86例[J].广西中医药,2004,27(4)：26
[27]马向明.针灸治疗溃疡性结肠炎76例[J].浙江中医杂志,2004,12(4)：358
[28]刘兴山,胡英华.合募配穴结合灸法治疗溃疡性结肠炎62例临床观察[J].中国社区医师,2005,21(总第271期)：39
[29]李宏军,李国萍,李宏岩.穴位埋线治疗溃疡性结肠炎临床观察[J].中国针灸,2006,26(4)261
[30]苗春红.李杂冰,李权,等.穴位强化埋线疗法治疗慢性非特异性溃疡性结肠炎的自身对照研究汇[J].北京中医,2007,26(5)：266
[31]朱莹,袁伟建,白晓明.穴位埋线对溃疡性结肠炎淋巴细胞调往调控蛋白的影响[J].中医杂志,2007,48(6)；526
[32]王洪伟,等.水罐疗法加针刺治疗溃疡性结肠炎56例[J].中国针灸,2005,25(1)：14
[33]Macfarlane S, Furrie E, Cummings JH,et al. Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis [J]. Clip Infect Dis,2004,38:1690-1699
[34]Ohkusa T, Sato N, Ogihara T, et al. Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody[J]. J Gastroenterol Hep atol,2002,17:849-853
[35]Hanauer SB. Update on the etiology, pathogenesis and diagnosis of ulcerative colitis [J]. Nat Clin Pract Gastroenterol Hepatol,2004,1:26-31
[36]桑力轩,刘汉立,姜敏.溃疡性结肠炎发病机制研究进展[J].世界华人消化杂志,2007,15(20)：2249-2254
[37]关军丽.溃疡性结肠炎的病因研究现状[J].山西医药杂志,2010,39(10)：944-945
[38]Boyko EJ, Perera DR, Koepsell TD, et al Effects ofcigarette smoking on the clinical course of ulcerative colitis[J]. ScandJ Gastroenterol,1988,23:1147-1152
[39]Birrenbach T, Bocker U. Inflammatory bowel disease and smoking:a review of e-pidemiology, pathophysiology, and therapeutic implications[J]. Inflamm Bowel Dis 2004,10:848-859
[40]Comes J.Tobacco and IBD:relevance in the understanding of disease mechanisms and clin ic al practice[J]. Best Pract Res Clin Gastroentero 1,2004,18:481-496
[41]白爱平,欧阳饮.益生茵治疗炎症性肠病的机制[J].胃肠病学,2005,10：240-242
[42]熊德鑫.现代微生态学[M].北京：中国科学技术出版社,2000：252-255
[43]Macfarlane S, Furrie E, Cummings JH, et al. Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis[J]. Clin Infect Dis 2004,38:1690-1699
[44]FEDORAK RN,MADSEN KL.Probiotics and the management of inflammatory bowel diseasefJ]. Inflamm Bowel Dis 2004,10(3):286-299
[45]刘力,张欢.肠道菌群失调与溃疡性结肠炎[J].现代中医药,2010,30(2)：45-47
[46]刘贡阳,陈东风.肠道茵群在炎症性肠病发病中的作用[J].贡庆医学,2009,38(10)：1251-1253
[47]Kleessen B, Kroesen AJ, Buhr HJ, et al. Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls[J]. Scand J Gastroenterol 2002,37:1034-1041
[48]王新月,川德禄.溃疡性结肠炎病因病理特点与中医辨治思路[J].北京中医药大学学报,2007,30(8)：554-556
[49]中华中医药学会脾胃病分会.溃疡性结肠炎中医诊疗共识意见[J].中华中医药杂志,2010,25(6)：891-895
[50]徐景藩.溃疡性结肠炎反复发作的防治对策[J].江苏中医药,2006,21(7)：14-15
[51]沈洪.溃疡性结肠炎治疗用药的儿个特点[J].江苏中医药,2006,2(7)：15-16
[52]SFDA.中药临床研究指导原则(试行)[S].北京：中国医药科技出版社,2002：129-134
[53]杨旭,张苏闽.溃疡性结肠炎的中医药外治研究进展[J].中医药导报,2011,17(2)：91-94
[54]吴东,孙健平,吴军,等.自拟灌肠1号结合中药内服治疗慢性溃疡性结肠炎90例分析[J].现代中西医结合杂志,2007,16(3)：338-339
[55]朱勇,谢会忠.锡类散与美沙拉嗪灌肠治疗溃疡性结肠炎的疗效比较[J].世界华人消化杂志,2008,16(32)：3700-3703
[56]中华医学会消化病学分会炎症性肠病协作组.对我国炎症性肠病诊断治疗规范的共识意见[J].现代消化及介入诊疗,2008,13(2)：139
[57]Marteau Probert CS,Lindgren S, et al.Combine oral and enema treahneu with pentasa(mPSalazine) is superior to oral therapy alone in pat ient s with ext ensive mild/moderate act ive ulcerative colitis:a randomized, double blind, placebo controlled study[J]. Gut,2005,54(7):960
[58]郑家驹.结肠炎症性疚病手册[M].北京：科学出版社,2007：148-149
[59]叶任高.陆再英.内利学[M].化京：人民卫生出版社,2004：411
[60]陈劲勇,周志光,王跃平.柳氮磺胺吡啶加中药与单用柳氮磺胺吡啶在溃疡性结肠炎中的疗效比较[J]中国新药临床杂志,2003,22(5).287
[61]Williams CN. Scan J Gustroenterol 1988,10:406
[62]屠恒来,徐富星.溃疡性结肠炎局部治疗的现状与进展[J].临床内科杂志,1995,12(2)：17
[63]毛俊浩,吕志良,曾群力,等.白术多糖对小鼠淋巴细胞功能的调节[J].免疫学杂志1996,12(4)：233-236
[64]冉先穗.中华药海[M].哈尔滨：哈尔滨出版社,1998：1588-1589
[65]龙全江,徐雪琴,胡吻.白术的化学、药理与炮制研究进展[J].中国中医药信息杂杂志2004,11(11)：1033-1034
[66]陈华萍,吴万征.白术的研究进展[J].广东药学,2002,12(5)：19-21
[67]缪建春,蔡威黔.天然药物抗类风湿关节炎作用的研究进展[J].医药导报,2010,29(7)：872-874
[68]杨志彬.芍药汤加减灌肠治疗溃疡性结肠炎36例[J].四川中医,1995,(3)：33
[69]姜建萍.白芍的现代药理研究及临床应用概况[J].中医药信息,2000,(3)：6-8
[2]Regueiro MD. Diagnosis and treatment of ulcerative proctitis[J]. Clin Gastroenterol,2004,38:733-740
[3]宇都宫利善.溃疡性大肠炎患者的年龄分布与发病年龄的若年化[R].厚生省特定疾患“难治性炎症性肠管障害”调查研究班.平成3年度研究报告书,1991：181-187
[4]项平,徐富垦,欧平安.溃疡性结肠炎486例结肠镜查的评价和分析[J].中华消化杂志,1996,16：136-138
[5]北洞哲治.炎症性肠疾患的疫学[J].临床杂志内科,1998,82：209-213
[6]Lamet M, Ptak T, Dallaire C, et al. Mesalamine Study Group. Efficacy and safety of mesalamine 1 g HS versus 500 mg BID suppositories in mild to moderate ulcerative proctitis:a multicenter randomized study. Inflamm Bowel Dis,2005,11:625-630
[7]陈锦峰,陈建林,韩宇斌,等.芍药汤合白头翁汤治疗轻中度溃疡性结肠炎(湿热内蕴型)30例疗效观察[J].新中医,2008,40(7)：48
[8]陈亚龙,钟晖.抑肝扶脾法治疗慢性溃疡性结肠炎临床观察[J].四川中医,2008,26(7)：52
[9]张相安.辨证分型治疗溃疡性结肠炎69例[J].医药论坛杂志,2008,29(10)：71
[10]韩远茹.中医治疗溃疡性结肠炎研究纂要[J].实用内科学杂志,2008,22(8)：70
[11]吴东,孙健平,吴军,等.自拟灌肠1号结合中药内服治疗慢性溃疡性结肠炎90例分析[J].现代中西医结合杂志,2007,16：338-339
[12]Kombluth A, SacharDB. Ulcerative colitis practice guidelines in adults(update):American College of Gastroenterology[J]. Practice Parameters Committee.Am Gastroenterol,2004,99:1371-1385
[13]康晓玲.中药灌肠治疗慢性非特异性溃疡性结肠炎60例[J].西北药学杂志,2005,20(3)：130
[14]张茄,曾莉.二黄汤结合穴位埋线治疗溃疡性结肠炎临床研究[J].时珍国医国药,2007,18(9)：2268
[15]郭晓原,龙再菊,吴霞,等.针灸配合中药灌肠治疗溃疡性结肠炎22例疗效观察[J].辽宁中医杂志,2007,34(5)：654
[16]李根丑,彭全利.参苓白术散加味治疗溃疡性结肠炎63例[J].陕西中医,2008,29(1)：51
[17]吴蔚,倪斐琳.改良保留灌肠方法治疗溃疡性结肠炎35例观察[J].实用中医内科杂志,2007,21(4),81
[18]王文文,郑萍.苦参合剂直肠滴入法治疗溃疡性结肠炎28例[J].中医外治杂志,2001,10(1);8
[19]陈雁敏,邹翠芳.改良中药保留灌肠法在溃疡性结肠炎治疗中的应用[J].中医中药,2007,4(14)；87
[20]陈霞.中药直肠点滴治疗慢性溃疡性结肠炎65例疗效观察[J].云南中医药,2003,24(3);12
[21]张杰,曾宇锋,肖斌琼,等.致康胶囊复合液灌肠联合结肠镜局部喷注治疗溃疡性结肠炎志者52例[J].中国中西医结合杂志,2005,25(9)：839
[22]曹健彪,李雅君,张红光,等.128例溃疡性结肠炎的镜资料分析[J].中国内镜杂志,2000,6(1)：21-22
[23]林锡芬,陈金泉,张苏闽。气药灌肠法治疗慢性溃疡性结肠炎36例疗效观察[J].新中医,2003,35(7)：24-25
[24]张苏闽,吴昆岚,丁义江,等.气药灌肠治疗溃疡性结肠炎的临床实验研究(附60例资料分析)[J].东南大学学报,2002,21(4)：310-312
[25]张悦,杨振辉.针刺夹脊穴配合梅花针叩刺治疗溃疡性结肠炎43例[J].中医杂志,2003,44(4)：282-283
[26]年云娜.针刺董氏奇穴合拔罐治疗慢性非特异性溃疡性结肠炎86例[J].广西中医药,2004,27(4)：26
[27]马向明.针灸治疗溃疡性结肠炎76例[J].浙江中医杂志,2004,12(4)：358
[28]刘兴山,胡英华.合募配穴结合灸法治疗溃疡性结肠炎62例临床观察[J].中国社区医师,2005,21(总第271期)：39
[29]李宏军,李国萍,李宏岩.穴位埋线治疗溃疡性结肠炎临床观察[J].中国针灸,2006,26(4)261
[30]苗春红.李杂冰,李权,等.穴位强化埋线疗法治疗慢性非特异性溃疡性结肠炎的自身对照研究汇[J].北京中医,2007,26(5)：266
[31]朱莹,袁伟建,白晓明.穴位埋线对溃疡性结肠炎淋巴细胞调往调控蛋白的影响[J].中医杂志,2007,48(6)；526
[32]王洪伟,等.水罐疗法加针刺治疗溃疡性结肠炎56例[J].中国针灸,2005,25(1)：14
[33]Macfarlane S, Furrie E, Cummings JH,et al. Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis [J]. Clip Infect Dis,2004,38:1690-1699
[34]Ohkusa T, Sato N, Ogihara T, et al. Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody[J]. J Gastroenterol Hep atol,2002,17:849-853
[35]Hanauer SB. Update on the etiology, pathogenesis and diagnosis of ulcerative colitis [J]. Nat Clin Pract Gastroenterol Hepatol,2004,1:26-31
[36]桑力轩,刘汉立,姜敏.溃疡性结肠炎发病机制研究进展[J].世界华人消化杂志,2007,15(20)：2249-2254
[37]关军丽.溃疡性结肠炎的病因研究现状[J].山西医药杂志,2010,39(10)：944-945
[38]Boyko EJ, Perera DR, Koepsell TD, et al Effects ofcigarette smoking on the clinical course of ulcerative colitis[J]. ScandJ Gastroenterol,1988,23:1147-1152
[39]Birrenbach T, Bocker U. Inflammatory bowel disease and smoking:a review of e-pidemiology, pathophysiology, and therapeutic implications[J]. Inflamm Bowel Dis 2004,10:848-859
[40]Comes J.Tobacco and IBD:relevance in the understanding of disease mechanisms and clin ic al practice[J]. Best Pract Res Clin Gastroentero 1,2004,18:481-496
[41]白爱平,欧阳饮.益生茵治疗炎症性肠病的机制[J].胃肠病学,2005,10：240-242
[42]熊德鑫.现代微生态学[M].北京：中国科学技术出版社,2000：252-255
[43]Macfarlane S, Furrie E, Cummings JH, et al. Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis[J]. Clin Infect Dis 2004,38:1690-1699
[44]FEDORAK RN,MADSEN KL.Probiotics and the management of inflammatory bowel diseasefJ]. Inflamm Bowel Dis 2004,10(3):286-299
[45]刘力,张欢.肠道菌群失调与溃疡性结肠炎[J].现代中医药,2010,30(2)：45-47
[46]刘贡阳,陈东风.肠道茵群在炎症性肠病发病中的作用[J].贡庆医学,2009,38(10)：1251-1253
[47]Kleessen B, Kroesen AJ, Buhr HJ, et al. Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls[J]. Scand J Gastroenterol 2002,37:1034-1041
[48]王新月,川德禄.溃疡性结肠炎病因病理特点与中医辨治思路[J].北京中医药大学学报,2007,30(8)：554-556
[49]中华中医药学会脾胃病分会.溃疡性结肠炎中医诊疗共识意见[J].中华中医药杂志,2010,25(6)：891-895
[50]徐景藩.溃疡性结肠炎反复发作的防治对策[J].江苏中医药,2006,21(7)：14-15
[51]沈洪.溃疡性结肠炎治疗用药的儿个特点[J].江苏中医药,2006,2(7)：15-16
[52]SFDA.中药临床研究指导原则(试行)[S].北京：中国医药科技出版社,2002：129-134
[53]杨旭,张苏闽.溃疡性结肠炎的中医药外治研究进展[J].中医药导报,2011,17(2)：91-94
[54]吴东,孙健平,吴军,等.自拟灌肠1号结合中药内服治疗慢性溃疡性结肠炎90例分析[J].现代中西医结合杂志,2007,16(3)：338-339
[55]朱勇,谢会忠.锡类散与美沙拉嗪灌肠治疗溃疡性结肠炎的疗效比较[J].世界华人消化杂志,2008,16(32)：3700-3703
[56]中华医学会消化病学分会炎症性肠病协作组.对我国炎症性肠病诊断治疗规范的共识意见[J].现代消化及介入诊疗,2008,13(2)：139
[57]Marteau Probert CS,Lindgren S, et al.Combine oral and enema treahneu with pentasa(mPSalazine) is superior to oral therapy alone in pat ient s with ext ensive mild/moderate act ive ulcerative colitis:a randomized, double blind, placebo controlled study[J]. Gut,2005,54(7):960
[58]郑家驹.结肠炎症性疚病手册[M].北京：科学出版社,2007：148-149
[59]叶任高.陆再英.内利学[M].化京：人民卫生出版社,2004：411
[60]陈劲勇,周志光,王跃平.柳氮磺胺吡啶加中药与单用柳氮磺胺吡啶在溃疡性结肠炎中的疗效比较[J]中国新药临床杂志,2003,22(5).287
[61]Williams CN. Scan J Gustroenterol 1988,10:406
[62]屠恒来,徐富星.溃疡性结肠炎局部治疗的现状与进展[J].临床内科杂志,1995,12(2)：17
[63]毛俊浩,吕志良,曾群力,等.白术多糖对小鼠淋巴细胞功能的调节[J].免疫学杂志1996,12(4)：233-236
[64]冉先穗.中华药海[M].哈尔滨：哈尔滨出版社,1998：1588-1589
[65]龙全江,徐雪琴,胡吻.白术的化学、药理与炮制研究进展[J].中国中医药信息杂杂志2004,11(11)：1033-1034
[66]陈华萍,吴万征.白术的研究进展[J].广东药学,2002,12(5)：19-21
[67]缪建春,蔡威黔.天然药物抗类风湿关节炎作用的研究进展[J].医药导报,2010,29(7)：872-874
[68]杨志彬.芍药汤加减灌肠治疗溃疡性结肠炎36例[J].四川中医,1995,(3)：33
[69]姜建萍.白芍的现代药理研究及临床应用概况[J].中医药信息,2000,(3)：6-8