微反应器中快速氧化反应和低温锂卤交换反应研究
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摘要
第一章：微反应器技术作为一种全新的有机合成方法受到科研工作者的广泛关注,在各科研领域都发挥越来越重要的作用。微反应器是直径在10-1000μm的管道式反应器。与传统反应容器相比,微反应器提高了反应的安全性和选择性,并且方便于工业放大。
第二章：随着微反应器应用的不断推广,在微反应器中进行的有机反应种类也越来越繁多。针对的不同的反应类型和所需要的最佳反应条件,科研工作者尝试制作各种不同类型的微反应器来满足不同的需求。本章主要介绍了本课题组构建微反应器的方法和在使用过程中的故障排除等相关知识。
第三章：我们对微反应器中进行的叔丁基过氧化氢和次氯酸钠体系进行研究,我们设计构建了两进样的绿色微反应器系统并用此系统成功的进行了该氧化反应,在很短的时间内高效的合成了产物。相对于传统的反应容器,微反应器大大提高了反应效率。
第四章：本章主要对微反应器中进行的以锂卤交换为代表反应的初步探索。根据常规反应容器中的相关信息和参数,我们将反应导入微反应器中,并成功的进行了探索。我们建立的这一套微反应体系也可以应用到其他低温反应的研究中去,为优化低温类型的反应提供了新的方案。
Chapter 1:As a new type of organic synthesis methods, micro reactor technology has received lots of attentions from both the academic and industrial viewpoints. Micro reactor is sort of pipe line reactor with diameter from 10 to 1000μm. Compared with conventional macroscale batch reactors, it exhibit numerous practical advantages, including safety, easy modulation, and easy scale up for industrial production. In this chapter, the development and application of micro reactor was reviewed.
Chapter 2:Along with the further promotion of micro reactor application, more and more organic reaction types were introduced in. According to the different reaction type and conditions, all sorts of types were created by research workers to meet different needs. In this chapter, materials, drives and potential application devices of micro reactor were introduced, and current fabrication of micro reactor were compared.
Chapter 3:An efficient procedure of benzylic compounds oxidation was described, which is facile, economical and environmentally friendly. The oxidation can be accomplished in a good yield within 10 seconds at room temperature. A new synthetic method in microreactor to synthesize carbonyl compounds which tolerates various substrates is developed. Compared with the conventional method, good to excellent yields have been obtained within a very short reaction time.
Chapter 4:Micro reactors also enable the precise control of reactive intermediates and thereby facilitate highly selective reactions which difficult to achieve in conventional reactors. The Li-Br exchange reaction in micro reactor at low temperature were studied. And the micro reactor was used to control the active intermediates. Using our micro reactor, a really good performance in Li-Br exchange reaction can be achieved.
第二章：随着微反应器应用的不断推广,在微反应器中进行的有机反应种类也越来越繁多。针对的不同的反应类型和所需要的最佳反应条件,科研工作者尝试制作各种不同类型的微反应器来满足不同的需求。本章主要介绍了本课题组构建微反应器的方法和在使用过程中的故障排除等相关知识。
第三章：我们对微反应器中进行的叔丁基过氧化氢和次氯酸钠体系进行研究,我们设计构建了两进样的绿色微反应器系统并用此系统成功的进行了该氧化反应,在很短的时间内高效的合成了产物。相对于传统的反应容器,微反应器大大提高了反应效率。
第四章：本章主要对微反应器中进行的以锂卤交换为代表反应的初步探索。根据常规反应容器中的相关信息和参数,我们将反应导入微反应器中,并成功的进行了探索。我们建立的这一套微反应体系也可以应用到其他低温反应的研究中去,为优化低温类型的反应提供了新的方案。
Chapter 1:As a new type of organic synthesis methods, micro reactor technology has received lots of attentions from both the academic and industrial viewpoints. Micro reactor is sort of pipe line reactor with diameter from 10 to 1000μm. Compared with conventional macroscale batch reactors, it exhibit numerous practical advantages, including safety, easy modulation, and easy scale up for industrial production. In this chapter, the development and application of micro reactor was reviewed.
Chapter 2:Along with the further promotion of micro reactor application, more and more organic reaction types were introduced in. According to the different reaction type and conditions, all sorts of types were created by research workers to meet different needs. In this chapter, materials, drives and potential application devices of micro reactor were introduced, and current fabrication of micro reactor were compared.
Chapter 3:An efficient procedure of benzylic compounds oxidation was described, which is facile, economical and environmentally friendly. The oxidation can be accomplished in a good yield within 10 seconds at room temperature. A new synthetic method in microreactor to synthesize carbonyl compounds which tolerates various substrates is developed. Compared with the conventional method, good to excellent yields have been obtained within a very short reaction time.
Chapter 4:Micro reactors also enable the precise control of reactive intermediates and thereby facilitate highly selective reactions which difficult to achieve in conventional reactors. The Li-Br exchange reaction in micro reactor at low temperature were studied. And the micro reactor was used to control the active intermediates. Using our micro reactor, a really good performance in Li-Br exchange reaction can be achieved.
引文
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